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Funded Research

2023 NIH Director's New Innovator Award (DP2) (RFA-RM-22-019)

*Diversity Statement

PI NameInstitution NameTitle
AGUADO, BRIAN ALBERTOUNIVERSITY OF CALIFORNIA, SAN DIEGOProbing sex differences in myocardial fibrosis at multiple length scales using biomaterials
ARIGO, DANIELLEROWAN UNIVERSITYA Paradigm Shift in Health Behavior Change: Understanding When and How Social Comparison Supports Healthy Behavior
AYDOGAN, MUSTAFA GONENCUNIVERSITY OF CALIFORNIA, SAN FRANCISCODecoding the fundamental principles of autonomous clocks: mechanism, design and function
BALDWIN, KATHERINE THERESEUNIV OF NORTH CAROLINA CHAPEL HILLThe facts of the matter: decoding the molecular properties of brain white matter using cell-type-specific quantitative proteomics
BANIK, STEVENSTANFORD UNIVERSITYMapping and Therapeutic Hijacking of Lysosomal Transport
BARTELLE, BENJAMIN BARIZONA STATE UNIVERSITY-TEMPE CAMPUSBioengineering Tools to Resolve and Manipulate Neuroimmune Signaling
BOSE, ROHITUNIVERSITY OF CALIFORNIA, SAN FRANCISCOSimulating Ancestrally Unbiased Tumor Evolution To Interrogate Drug Resistance
BURTON, NICHOLAS OVAN ANDEL RESEARCH INSTITUTEIDENTIFYING MICROBIAL MECHANISMS THAT REGULATE ANIMAL INSULIN SIGNALING
CARTER, CALVINUNIVERSITY OF IOWATargeting evolutionarily encoded molecular antennae to wirelessly reprogram systemic metabolism
COYLE, SCOTT MUNIVERSITY OF WISCONSIN-MADISONCellular FM-radios: seeing, probing, and perturbing single-cell protein activity dynamics in biological systems with frequency-barcoded spatiotemporal signaling circuits
CROOK, NATHAN CNORTH CAROLINA STATE UNIVERSITY RALEIGHBrewing anti-toxin drugs using probiotic yeast
CROUCH, ELIZABETH ERINUNIVERSITY OF CALIFORNIA, SAN FRANCISCOVascular mural cells in the development of the blood brain barrier
DIETLEIN, FELIXBOSTON CHILDREN'S HOSPITALDefining the universal genomic language of hallmarks in tumor development
DRAGANOVA, ELIZABETH BENNETTEMORY UNIVERSITYUnder Pressure: Biophysical Mapping of Herpesvirus Capsid Assembly and Genome Packaging
FARNUNG, LUCASHARVARD MEDICAL SCHOOLVisualizing mechanisms at the intersection of chromatin, transcription, and epigenetics
FERNANDEZ-RUIZ, ANTONIOCORNELL UNIVERSITYHow do animals learn the structure of their natural environment?
FURST, ARIEL LESAMASSACHUSETTS INSTITUTE OF TECHNOLOGYProtecting microbes so they can protect us
GAO, RUIXUANUNIVERSITY OF ILLINOIS AT CHICAGOA biochemical approach towards subcellular, label-free molecular imaging
GAO, XIAOJING JSTANFORD UNIVERSITYA Novel Class of Synthetic Receptors to Empower the Age of mRNA Therapies
GOLDSTEIN, RACHEL EUNIV OF MARYLAND, COLLEGE PARKWater Emergency Team (WET): Community-Driven Rapid Response Team to Evaluate Antibiotic-Resistant Bacteria Exposures and Household Environmental Health Risks from Sewer Overflows and Basement Flooding
GRIENBERGER, CHRISTINEBRANDEIS UNIVERSITYUnraveling the synaptic and circuit mechanisms underlying a plasticity-driving instructive signal
HOLEHOUSE, ALEX SWASHINGTON UNIVERSITYUncovering the regulatory logic of gene expression encoded by disordered regions
JAYANT, KRISHNAPURDUE UNIVERSITYMassively scalable 3D electrophysiology and two-photon imaging in freely-moving animals
JOST, MARCOHARVARD MEDICAL SCHOOLCapturing, quantifying, and understanding combinatorial effects in small molecule signaling
KIM, CHRISTINAUNIVERSITY OF CALIFORNIA AT DAVISActivity-dependent probes for spatially-defined proteomics
KO, JIN AUNIVERSITY OF PENNSYLVANIADroplet-based Spatially Encoded Live Cell Digital Extraction
LEVINSON, CHERI ALICIALEVINSON, CHERI ALICIAInnovations in Personalizing Treatment for Eating Disorders Using Idiographic Methods and the Impact of Personalization on Psychological, Physical, and Sociodemographic Outcomes
LI, JIAHENORTHEASTERN UNIVERSITYEnzymatic and genetic strategies for targeting disease-associated microbial metabolites
LODATO, MICHAEL ANTHONYUNIV OF MASSACHUSETTS MED SCH WORCESTERSpatial single-cell analysis of somatic mutation in human brain during aging and neurodegeneration
LORD, NATHAN DALEUNIVERSITY OF PITTSBURGH AT PITTSBURGHDecoding the Spatial Grammar of Developmental Signaling
LOVETT-BARRON, MATTHEWUNIVERSITY OF CALIFORNIA, SAN DIEGOFunctional maturation of neural circuits for biological motion perception and social engagement
MADDIPATI, RAVIKANTHUT SOUTHWESTERN MEDICAL CENTEROptogenetic engineering of tumor topography in native tissue environments
MARTIK, MEGAN LEEUNIVERSITY OF CALIFORNIA BERKELEYReactivating regulatory programs for regeneration
MILLER, MICHAEL BBRIGHAM AND WOMEN'S HOSPITALIlluminating neurodegenerative tauopathy from somatic genomic landscapes of single human brain cells
MUNJAL, AKANKSHIDUKE UNIVERSITYMulti-scale feedbacks for robust organ development
MUSAH, SAMIRADUKE UNIVERSITYHarnessing stem cells and synthetic gene circuits to repair glomerular injury
ODONNELL, MICHAEL PATRICKYALE UNIVERSITYMolecular determinants of host-feeding manipulation and microbial colonization
PODGORSKI, KASPARALLEN INSTITUTEMeasuring input-output operations of cortical neurons with large-scale neurotransmitter imaging
RAY, JOHN PHILIPBENAROYA RESEARCH INST AT VIRGINIA MASONInvestigating Genetic and Epigenetic Control of T Cell Function in Autoimmunity
RIJO-FERREIRA, FILIPAUNIVERSITY OF CALIFORNIA BERKELEYDefining and Exploiting the Circadian Clocks in Malaria Parasites
RODRIGUEZ, NATALIA MARIAPURDUE UNIVERSITYAddressing Cervical Cancer Disparities Among People Experiencing Homelessness
SCHMITT, DANIELLE LYNANNEUNIVERSITY OF CALIFORNIA LOS ANGELESImaging Spatiotemporal Regulation of Acetyl-CoA
SHYER, AMY ELIZABETHROCKEFELLER UNIVERSITYStudying the cellular ecology of organ formation using a novel tissue reconstitution system
SINGH, PARAM PRIYAUNIVERSITY OF CALIFORNIA, SAN FRANCISCODecoding natural protective mechanisms during diapause and longevity to counter aging
SOLTANOLKOTABI, MAHDIUNIVERSITY OF SOUTHERN CALIFORNIAReliable AI for Medical Image Reconstruction
STERN, SARAHMAX PLANCK FLORIDA CORPORATIONIdentifying neurons for interoception using simultaneous profiling of activity- and projection- specific populations
SZABLOWSKI, JERZY OLGIERDRICE UNIVERSITYMonitoring neuronal activity with a blood test - Released Markers of Activity (RMA)
TISON, GEOFFREY HUNIVERSITY OF CALIFORNIA, SAN FRANCISCOA physiologically-focused approach to training multi-modality AI algorithms in medicine
TOWERS, CHRISTINA GSALK INSTITUTE FOR BIOLOGICAL STUDIESTracking the Mechanisms of Adaptation to Autophagy Inhibition
VASAN, NEILCOLUMBIA UNIVERSITY HEALTH SCIENCESBase-Editing the Cancer Kinome to Enable Drug Discovery
VENKATESH, HUMSABRIGHAM AND WOMEN'S HOSPITALUnraveling Neural Circuitry in Peripheral Cancer Pathogenesis: From Local Innervation to Systemic Influences
VLASSAKIS, JULEARICE UNIVERSITYDeep phenotyping of fusion oncoprotein-driven pediatric cancer metastasis with single-cell proteomics
WASHINGTON, PETERUNIVERSITY OF HAWAII AT MANOACrowd-Powered Machine Learning to Diagnose ASD and ADHD in Adolescents from Digital Social Interactions
XIE, LIANGQICLEVELAND CLINIC LERNER COM-CWRULive-Cell Chromatin Imaging and Biology: Application to Extrachromosomal DNA
YADAV, AMOL PINDIANA UNIV-PURDUE UNIV AT INDIANAPOLISSensory Augmentation, Restoration, and Modulation Using a Spinal Neuroprosthesis
YU, XINZHUUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGNFunctional, Structural and Molecular Decoding of Astrocyte-Neuron Interaction
ZHOU, XINDANA-FARBER CANCER INSTEngineering programmable enzymes for proteome editing
ZHU, CHENXUNEW YORK GENOME CENTERStudying the Regulatory Dynamics with Single-cell Multiomics

 

2022 NIH Director's New Innovator Award (DP2) (RFA-RM-21-016)

*Diversity Statement

PI NameInstitution NameTitle
ALAMBEIGI, FARSHIDUNIVERSITY OF TEXAS AT AUSTINA Novel Semi-Autonomous Surgeon-in-the-Loop In Situ Robotic Bioprinting System for Functional and Cosmetic Restoration of Volumetric Muscle Loss Injuries
AREY, RACHEL NICOLEBAYLOR COLLEGE OF MEDICINEUncovering Brain-Wide Molecular Determinants of Individual Memory Performance Across Lifespan
BEYELER, MICHAELUNIVERSITY OF CALIFORNIA SANTA BARBARATowards a Smart Bionic Eye: AI-Powered Artificial Vision for the Treatment of Incurable Blindness
BLAZECK, JOHN JAMESGEORGIA INSTITUTE OF TECHNOLOGYSynthetic Metabolism to Armor and Enhance a New Class of Cell Therapies
BUCKLEY, RACHEL FRANCESMASSACHUSETTS GENERAL HOSPITALThe Inactive X: Discovering Sex Genes That Influence Female Vulnerability to Alzheimers Disease
CASE, LINDSAYMASSACHUSETTS INSTITUTE OF TECHNOLOGYNew Insights Into the Molecular Regulation of Mechanotransduction
CHAN, MICHELLEPRINCETON UNIVERSITYBuilding a Systematic, Comprehensive Mammalian Cell Fate Map
CHANG, CHI-LUNST. JUDE CHILDREN'S RESEARCH HOSPITALUnderstanding Metabolism in Space and Time – Mechanistic Analysis of the Dynamic Spatial Organization of Metabolism
CHAVEZ, ALEJANDROCOLUMBIA UNIVERSITY HEALTH SCIENCESMethods to Rapidly Explore Combinatorial Diversity and Their Application to CRISPR-Cas9 Systems
CHEADLE, LUCAS MCOLD SPRING HARBOR LABORATORYNeuroimmunological Insights Into Brain Development and Dysfunction: An Integrative Approach Focused on Microglial Dynamics
CHEN, XIAOYINALLEN INSTITUTEUnraveling the Developmental Logic of Cortical Long-Range Projections Using In Situ Sequencing-Based Neuroanatomy
CHRISTOPH, JANUNIVERSITY OF CALIFORNIA, SAN FRANCISCOAI-assisted Imaging and Prediction of Cardiac Arrhythmia Origins Using 4D Ultrasound
CLITES, TYLER RUNIVERSITY OF CALIFORNIA LOS ANGELESCompliant Limb Reconstruction: Co-engineering Body and Machine to Revolutionize Limb Salvage
DELANEY, JOE RMEDICAL UNIVERSITY OF SOUTH CAROLINATumor Suppressor Vulnerability Conferred by Aneuploid Loss of Haploinsufficient Metallothionein Genes
DING, FANGYUANUNIVERSITY OF CALIFORNIA-IRVINEUniversally-Applicable RNA Mapping at Subcellular and Single-Base Resolution
ESCOBAR HOYOS, LUISAYALE UNIVERSITYUnleashing T-Cell Anti-Tumor Response Through Repair of Altered RNA Splicing and Antigen Mimicry Recognition
ESCOLANO, AMELIAWISTAR INSTITUTEManipulating Epitope Immunodominance and Tracking B-cell-Antigen Interactions for Vaccine Design.
FEDER, ALISON FUNIVERSITY OF WASHINGTONA Phylodynamic Time Machine for Solid Tumors
FERGUSON, FLEUR MARCIAUNIVERSITY OF CALIFORNIA, SAN DIEGOChemical Control of Misfolded Protein Fate
FISHER, YVETTE EUNIVERSITY OF CALIFORNIA BERKELEYHow Does Neuromodulation Shape the Fluidity of Spatial Working Memory?
GADAGKAR, VIKRAMCOLUMBIA UNIVERSITY HEALTH SCIENCESThe Female Songbird as a Novel Mechanistic Model for the Neural Basis of Social Evaluation
GARCIA QUIROZ, FELIPEEMORY UNIVERSITYMultifunctional Phase Sensors for Probing and Manipulation of Intracellular Biomolecular Condensates
GAUBLOMME, JELLERTCOLUMBIA UNIV NEW YORK MORNINGSIDESpacially Mapping of Pooled In Vivo CRISPR Screens in the Tumor Microenvironment 
GOLDBERG, EMILY LAURENUNIVERSITY OF CALIFORNIA, SAN FRANCISCODiscovering Mechanisms of Tissue-Resident Immune Aging
GRANGER, ADAMBROAD INSTITUTE, INC.High-Throughput Methods for Measuring Cortical Synaptic Connectivity at Single-Cell Resolution
GRUBAUGH, NATHAN DALEYALE UNIVERSITYEnhancing Dengue Virus Genomic Surveillance to Uncover Circulating Genetic Diversity
HA, GAVINFRED HUTCHINSON CANCER CENTERTranslating the Tumor Regulome from Cell-Free DNA for Precision Oncology
HRVATIN, SINISAWHITEHEAD INSTITUTE FOR BIOMEDICAL RESBiology and Applications of Mammalian Hibernation-Like States
INAGAKI, HIDEHIKOMAX PLANCK FLORIDA CORPORATIONA Novel Approach to Crack Neuronal Mechanisms that Shape Computations in the Brain
JIN, CHENGCHENGUNIVERSITY OF PENNSYLVANIAA Blueprint for Neutrophil Heterogeneity and Reprogramming in Cancer
JOGLEKAR, ALOKUNIVERSITY OF PITTSBURGH AT PITTSBURGHSignaling Via MHC: Engineering Immune Cells with New Capabilities
KLEINSTIVER, BENJAMIN PETERMASSACHUSETTS GENERAL HOSPITALScalable Development of Custom Genome Editing Technologies
KUANG, ZHENGCARNEGIE-MELLON UNIVERSITYMicrobial Regulation of Mammalian Circadian Rhythms and the Sexual Dimorphism: From Metabolism to Immunity
KUNJAPUR, ADITYA MOHANUNIVERSITY OF DELAWAREBoosting Efficacy of Oral Vaccine Candidates by Enabling Spore Display of Nitrated Antigens
KVON, EVGENYUNIVERSITY OF CALIFORNIA-IRVINEDeciphering the Mechanism of Long-Range Gene Regulation In Vivo
LAPINAITE, AUDRONEARIZONA STATE UNIVERSITY-TEMPE CAMPUSEngineering Novel Precision Genome Editing Tools
LI, ZHONGWEIUNIVERSITY OF SOUTHERN CALIFORNIAThe Synthetic Kidney: A Revolutionary Solution for the Shortage of Kidneys for Transplantation
LIM, CI JIUNIVERSITY OF WISCONSIN-MADISONUnraveling the Telomere Black Box: A New Single-Molecule Approach to Define the Telomere Chromatin Landscape and its Functional Mechanisms
MAKINSON, CHRISTOPHER DONALDCOLUMBIA UNIVERSITY HEALTH SCIENCESUnlocking the Postnatal Human Brain Using Activity Augmented Organoids
MANSOOR, STEVEN ELIASOREGON HEALTH & SCIENCE UNIVERSITYElucidation of P2X7 Receptor Signaling and Development of Novel Small Molecule and Aptamer Ligand Therapies
MCKENNA, AARON HDARTMOUTH COLLEGEAnnotated Lineage Trees of Murine Development
MCKINLEY, KARA LAVIDGEHARVARD UNIVERSITYLife History of the Menstruating Uterus
MONK, ELLISHARVARD UNIVERSITYThe Optics of Health: Race Skin Tone Minority Health and Health Disparities in the U.S.
MOSALAGANTI, SHYAMALUNIVERSITY OF MICHIGAN AT ANN ARBORIn-Situ Architecture of Membrane Contact Sites Mediating Organelle Fission
MOUSAVI, MARALUNIVERSITY OF SOUTHERN CALIFORNIABuilding a Two-Way Communication System: Bio-Orthogonal Superhydrophobic Nanoparticles for Controlled Stimulation and Real-Time Sensing of Neurotransmitters
NATHAVITHARANA, RUVANDHIBETH ISRAEL DEACONESS MEDICAL CENTERTHWART-TB: Testing Health Workers At Risk to Advance Our Understanding of TB Infection
NIA, HADI TAVAKOLIBOSTON UNIVERSITY (CHARLES RIVER CAMPUS)Probing Functioning Lung at the Cellular Resolution in Health and Disease
NIEPA, TAGBO HERMAN ROLANDUNIVERSITY OF PITTSBURGH AT PITTSBURGHDesigning A High-Throughput Platform to Bioprospect the Human Microbiome and Manipulate Its Interplay with Host Environments
OKAFOR, C DENISEPENNSYLVANIA STATE UNIVERSITY, THEImproving Drug Design to Eliminate Side Effects: From Computational to Animal Models
PEARL, REBECCA LUNIVERSITY OF FLORIDATransdiagnostic Intervention to Reduce Internalized Health-Related Stigma
PONCE, CARLOS RAMONHARVARD MEDICAL SCHOOLDefining Mechanisms for Natural Vision in the Primate Brain with Machine Learning
RAJ, BUSHRAUNIVERSITY OF PENNSYLVANIAGenomic Tools for Massively Parallel Recording of Signaling Activity at Cellular Resolution in a Brain-Wide Manner
RISCA, VIVIANA IROCKEFELLER UNIVERSITYCross-Regulation Between Loop Extrusion, Chromatin Fiber Structure and Chromatin-Associated RNAs
ROUSKIN, SILVIAHARVARD MEDICAL SCHOOLConstructing the Nest - Understanding the Mechanisms of Nidoviridae RNA Genomes Transcription and Recombination
SANULLI, SERENASTANFORD UNIVERSITYHarnessing the Chromatin Conformational Code for Epigenetic Regulation
SARKAR, DEBLINAMASSACHUSETTS INSTITUTE OF TECHNOLOGYCirculatronics: A New Paradigm for Biomedical Implants
SCHOENEBERG, JOHANNESUNIVERSITY OF CALIFORNIA, SAN DIEGODecode Mitochondrial Morphology Dynamics to Predict Cell Fate Decisions
SEN, DEBATTAMA RAIMASSACHUSETTS GENERAL HOSPITALDissecting the Enhancer Logic Governing Immune Cell Fate Decisions
SHI, XIAOYUUNIVERSITY OF CALIFORNIA-IRVINEGel-based Optical-isolation Single-Cell 3D Spatial Multiomics
SKYLAR-SCOTT, MARK ASTANFORD UNIVERSITYTrillion Cell Culture to Fuel Organ Biofabrication
SMEETON, JOANNA MARJORIECOLUMBIA UNIVERSITY HEALTH SCIENCESDeciphering Multi-Dcale Fifferentiation and Patterning Cues Driving Whole Craniofacial Joint Regeneration
SOZEN, BERNAYALE UNIVERSITYDeciphering Principles of Human Embryonic Patterning in Development and Disease
STAVISKY, SERGEYUNIVERSITY OF CALIFORNIA AT DAVISUnderstanding and Restoring Speech Production Using an Intracortical Brain-Computer Interface
TE VELTHUIS, AREND JANPRINCETON UNIVERSITYStructure and Dynamics of RNA Elements Regulating Viral Aberrant RNA Synthesis
THYME, SUMMER BUNIVERSITY OF ALABAMA AT BIRMINGHAMDefining the Chemical Perturbome of Neural Development and Activity
UHLER, CAROLINEBROAD INSTITUTE, INC.Causal Representation Learning for the Spatial Analysis of Transcriptomic and Imaging Data in Tissue Contexts
VAN VALEN, DAVID ACALIFORNIA INSTITUTE OF TECHNOLOGYUnraveling the Genetic Basis of Cellular Behaviors with Deep Learning and Imaging-Based Reverse Genetics
WANG, CHAOARIZONA STATE UNIVERSITY-TEMPE CAMPUSIntegrated Nano-Opto-Fluidic System on Sapphire Towards Single-Molecule Protein Sequencing
WANG, SIHONGUNIVERSITY OF CHICAGOImmunocompatible Electronic Polymers and Devices for Implantable Sensors and Stimulators that Resist Foreign-Body Responses
WANG, WENJINGUNIVERSITY OF MICHIGAN AT ANN ARBORNew Classes of Optogenetic and Chemogenetic Tools with a Feedback Control
WEEKS, AMY MUNIVERSITY OF WISCONSIN-MADISONPost-Translational Modification Proteomics in 4D: Chemoenzymatic Tools to Map the Dynamic Spatial Organization of Eukaryotic Signaling Pathways
WHITELEY, AARON THOMASUNIVERSITY OF COLORADODeciphering the Crosstalk Between Bacteria and Their Mammalian Hosts
YOUNG, AARON JOHNGEORGIA INSTITUTE OF TECHNOLOGYA New Framework for Self-Adaptive Artificial Intelligence to Personalize Assistance for Patients Using Robotic Exoskeletons and Prostheses

 

2021 NIH Director's New Innovator Award (DP2) (RFA-RM-20-012)

*Diversity Statement

PI NameInstitution NameTitle
ABDELFATTAH, AHMEDBROWN UNIVERSITYLighting Up the Brain: Optogenetic Tools to Record, Trace, and Manipulate Brain Circuits at Cellular Resolution
ABU-REMAILEH, MONTHERSTANFORD UNIVERSITYInnovations and Mechanisms in Tumor Subcellular Metabolism
AHARONI, DANIELUNIVERSITY OF CALIFORNIA LOS ANGELESDeveloping Long-Term Neuro-Behavioral Recording and Real-Time Processing Platforms for Naturally Behaving Animals
ALHADEFF, AMBER LMONELL CHEMICAL SENSES CENTERHarnessing Sensory Food Circuits to Influence Feeding Behavior
BACKUS, KERIANN MARIEUNIVERSITY OF CALIFORNIA LOS ANGELESA Systems-Level Approach to Decipher the Protein Interactome
BLOSNICH, JOHN RUDOLPHUNIVERSITY OF SOUTHERN CALIFORNIAShifting Suicide Prevention Paradigms: Looking Beyond Clinical Settings
BRIGIDI, GIAN-STEFANOUNIVERSITY OF UTAHDecoding Neuronal Activity History at the Genome Through the Spatially Segregated Inducible Transcription Factors
BROWN, BREANNVANDERBILT UNIVERSITYOff the Beaten Path(Way): Spatiotemporal Investigation of Protein Assemblies Controlling Mitochondrial Metabolism
CANZIO, DANIELEUNIVERSITY OF CALIFORNIA, SAN FRANCISCOHow Do Neurons Recognize Self from Non-Self?
CAO, JUNYUEROCKEFELLER UNIVERSITYSingle Cell Dynamics on a Whole Organism Scale
CHOI, PETER SCHILDREN'S HOSP OF PHILADELPHIAExploring Hidden Determinants of Splicing with Genome-Targeted Proximity Labeling
ENGLISH, JUSTIN GUNIVERSITY OF UTAHDirected Evolution of Cell-Type Specific On-Demand Signaling Control Systems
FILBIN, MARIELLA GRUBERDANA-FARBER CANCER INSTHow the 3D Architecture of the Brain Shapes Cancer Cell Fate Decisions
FLEISCHER, CANDACE CEMORY UNIVERSITYA Novel Framework for Quantifying Metabolic Brain Health
GOMES, ANAH. LEE MOFFITT CANCER CTR & RES INSTAging as a Selective Pressure that Drives Tumor Progression
GONG, YI-NANUNIVERSITY OF PITTSBURGH AT PITTSBURGHNecrotic Survivors and Plasma Membrane Integrity Signaling
GORODETSKY, ALON AUNIVERSITY OF CALIFORNIA-IRVINECephalopod-Inspired Bioelectronic Control of Cellular Signaling
HEYS, JAMES GERARDUNIVERSITY OF UTAHUncovering the Neural Circuit and Synaptic Mechanisms Underlying Interval Timing
HOSSEINZADEH, PARISAUNIVERSITY OF OREGONA Data-Driven Approach Towards Generation of Permeable Peptide Therapeutics
HU, CHI-KUOSTATE UNIVERSITY NEW YORK STONY BROOKUnderstanding Diapause and Its Ability to Suspend and Preserve Life
JACKSON, RUAIDHRIHARVARD MEDICAL SCHOOLIlluminating the Immune Systems Genomic Dark Matter: Functionally Annotating the Hidden Translatome
KASOWSKI, MAYASTANFORD UNIVERSITYA Single Cell Pooling Framework for Deciphering the Regulatory Wiring of Allergy in Pathophysiologic Contexts
KEMALADEWI, DWI UTAMIUNIVERSITY OF PITTSBURGH AT PITTSBURGHImplications of Genetic Diversity in Muscular Dystrophy
KORB, ERICA MEGANUNIVERSITY OF PENNSYLVANIAThe Epigenetic Encoding of Learning and Memory
KRANZUSCH, PHILIP JDANA-FARBER CANCER INSTDiscovery of cGAS-Like Signaling Enzymes in Innate Immunity and Disease
KRASILEVA, KSENIA VUNIVERSITY OF CALIFORNIA BERKELEYCross-Kingdom Health: Evolution of Innate Immune Receptors and Their Targets
LAIDLAW, BRIANWASHINGTON UNIVERSITYEnhancing the Antiviral Memory B Cell Response
LEE, JOHN KYUNGFRED HUTCHINSON CANCER RESEARCH CENTERUncovering Diverse Genotype-Phenotype Relationships in Prostate Cancer
LI, GUANGUNIVERSITY OF PITTSBURGH AT PITTSBURGHGeneration of Four-Chambered Hearts Through Organoid Fusions
LI, PULINWHITEHEAD INSTITUTE FOR BIOMEDICAL RESSystematic Reconstruction of Epithelial-Mesenchymal Communication in Organ Development
MADIGAN, CRESSIDA ARIANNAUNIVERSITY OF CALIFORNIA, SAN DIEGOBacterial Disruption of Neuroimmune Pathways in a Transparent Brain
MAJZNER, ROBBIE GSTANFORD UNIVERSITYHijacking the T Cell Machinery for Logic-Gated CAR T Cell Control
MIHAYLOVA, MARIA MOHIO STATE UNIVERSITYDetermining Age-Dependent Metabolic Changes in Tumors and Their Microenvironment
MIR, MUSTAFA AIZED HASANCHILDREN'S HOSP OF PHILADELPHIA Quantifying the Dynamics of Gene Regulation and Nuclear Organization During Embryogenesis
MOK, WENDY W KUNIVERSITY OF CONNECTICUT SCH OF MED/DNTMapping Polymicrobial Interactions that Modulate Antibiotic Persistence
MURTHY, SWETHAOREGON HEALTH & SCIENCE UNIVERSITYA New Approach to Study Mechanically Activated Ion Channels
NEAL, JAMES THOMASBROAD INSTITUTE, INC.Optical Functional Genomics 
ORVEDAHL, ANTHONY WWASHINGTON UNIVERSITYAlveolus as Incubator: Functional Genomic Dissection of the Host Response to SARS-CoV-2 Infection.
OUDIN, MADELEINE JULIETUFTS UNIVERSITY MEDFORDDefining and Exploiting the Neuronal Identity of Cancers
PANDARINATH, CHETHANEMORY UNIVERSITYFusing Motor Neuroscience and Artificial Intelligence to Create Next-Generation Neural Prostheses
PERRY, JUSTIN SSLOAN-KETTERING INST CAN RESEARCHRethinking the "Quiet" Nature of Apoptotic Cell Clearance
PLESA, CALINUNIVERSITY OF OREGONProteome Scale Multiplexed Generation of Recombinant Antibodies
QUON, GERALDUNIVERSITY OF CALIFORNIA AT DAVISLinking Genetics to Cellular Behavior and Disease Via Multimodal Data Integration
RAMANI, VIJAYUNIVERSITY OF CALIFORNIA, SAN FRANCISCOSingle-Cell Chemical Transcriptomic Dissection of an Essential Transcription Factor Network
RITCHWOOD, TIARNEY DDUKE UNIVERSITYCommunity-Academic Partnerships to Address COVID-19 Inequities Within African American Communities
SAELICES GOMEZ, LORENAUT SOUTHWESTERN MEDICAL CENTERClosing the Gap Between Structural Biology and Translational Science for Amyloid Diseases
SHARMA, NIKHILCOLUMBIA UNIVERSITY HEALTH SCIENCESThe Cellular and Molecular Mechanisms Underlying Nociception and Pain
SIMUNOVIC, MIJOCOLUMBIA UNIV NEW YORK MORNINGSIDESynthetic Organogenesis: New Paradigms in Reconstituting Human Organ Development In Vitro
SMITH, CLARE MARGARETDUKE UNIVERSITYDissecting the Genetic Basis of Protective Immunity to Tuberculosis in Diverse Hosts
SMITH, ZACHARY DYLANYALE UNIVERSITYEpigenetic and Environmental Impact on Early Embryonic Development
SUN, BRYANUNIVERSITY OF CALIFORNIA, SAN DIEGOInsights to Noncoding Disease Variants Using Mosaic Diseases
SUN, LUUT SOUTHWESTERN MEDICAL CENTERMolecular and Genetic Decoding of Neuron-Glial Interactions
VOS, SEYCHELLE MONQIUEMASSACHUSETTS INSTITUTE OF TECHNOLOGYTowards Fully Reconstituting Mammalian Transcription in a Test Tube
WAGNER, DANIEL EUNIVERSITY OF CALIFORNIA, SAN FRANCISCMapping Cell Fate Flow and Feedback Control on Vertebrate Embryonic Landscapes
WAN, LILINGUNIVERSITY OF PENNSYLVANIAIlluminating Transcriptional Condensates Using an Integrated Approach
WAN, WILLIAM NVANDERBILT UNIVERSITYElucidating the Mechanisms of Viral Life Cycles Under Near-Native Conditions
WANG, XIAOBROAD INSTITUTE, INC.Single-Cell In Situ Analysis of RNA Modifications in Intact Tissues
WEAVER, JESSICA DIANEARIZONA STATE UNIVERSITY-TEMPE CAMPUSImmunosuppression-Free Transplantation Through Placental Mimicry
WENDLANDT, ALISONMASSACHUSETTS INSTITUTE OF TECHNOLOGLate Stage Stereochemical Editing to Transform the Synthesis of Bioactive Molecules
WONG, YVETTENORTHWESTERN UNIVERSITY AT CHICAGOThe Dynamic Architecture of Living Cells: Uncovering Intra-Organelle Events at Nanoscale Levels
WU, NICHOLAS CUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGNHigh-Throughput Identification of Antibody Features for Sequence-Based Epitope Prediction
YAN, JINGYALE UNIVERSITYTracking Single-Cell Gene Expression Heterogeneity and Its Consequences in Bacterial Biofilms
ZHAO, SHUANUNIVERSITY OF WISCONSIN-MADISONDynamic Molecular Evoluation of Treatment Resistant Cancer
ZHOU, JIANUT SOUTHWESTERN MEDICAL CENTERSequence Models of Genome Regulatory Architecture in 3D

 

2020 NIH Director's New Innovator Award (DP2) (RFA-RM-19-006)

*Diversity Statement

PI NameInstitution NameTitle
ACOSTA, VICTOR MARCELUNIVERSITY OF NEW MEXICONuclear Magnetic Resonance Microscope Based on Diamond Quantum Sensors
ALLEN, ALICIA MUNIVERSITY OF ARIZONAHormonal Response to Infant Caregiving: A Novel Strategy to Break the Opioid Relapse Cycle During the Postpartum Period
ANWAR, MEKHAILUNIVERSITY OF CALIFORNIA, SAN FRANCISCOImplantable Nanophotonic Sensors for In Vivo Immunoresponse
ARONOV, DMITRIYCOLUMBIA UNIVERSITY HEALTH SCIENCESUsing a Specialized Behavior to Study the Neural Mechanisms of Episodic Memory
BAO, HUANSCRIPPS FLORIDADeveloping Next-Generation Nanodiscs for the Study and Modulation of Membrane Proteins
BASU, ANINDITAUNIVERSITY OF CHICAGOProfiling Transcriptional Heterogeneity in Microbial Cells at Single Cell Resolution and High-Throughput Using Droplet Microfluidics
BIRNBAUM, MICHAELMASSACHUSETTS INSTITUTE OF TECHNOLOGYRepertoire-Scale T Cell Antigen Identification Via Peptide-Mhc Lentivirus Display
CONSTANTINOPLE, CHRISTINE MARIENEW YORK UNIVERSITYNeural Circuit Mechanisms of Arithmetic for Economic Decision-Making
CORDER, GREGORYUNIVERSITY OF PENNSYLVANIAHarnessing Cortical Neuromodulation to Disrupt Pain Perception
DASGUPTA, SUBHAMOYROSWELL PARK CANCER INSTITUTE CORPDecoding the Nuclear Metabolic Processes Regulating Gene Transcription
DEMAZUMDER, DEEPTANKARUNIVERSITY OF CINCINNATIEavesdropping on Heart-Brain Conversations During Sleep for Early Detection and Prevention of Fatal Cardiovascular Disease
FALKNER, ANNEGRET LEAPRINCETON UNIVERSITYGenerating Pro-Resilient States Through Individualized Circuit Read-Write Therapeutics
FONT-BURGADA, JOANRESEARCH INST OF FOX CHASE CAN CTRNew Tools for Understanding Metastasis Through Tissue Resident Cells: Enabling an Extensive Medicine Strategy for Metastatic Disease
FRIED, STEPHEN DAVIDJOHNS HOPKINS UNIVERSITYWatching Proteins Fold (or Misfold) In Vivo with Mass Spectrometry
GUO, FENGINDIANA UNIVERSITY BLOOMINGTONAn Acoustofluidic Avidity Cytometer for Massive Parallel Profiling Single Autoreactive T Cell in Autoimmune Disease
HAI, AVIADUNIVERSITY OF WISCONSIN-MADISONAchieving Direct Functional Imaging of Brain Electrophysiology: Nanofabricated Cell-Sized Electronic Sensors for Magnetic Resonance Imaging
HANSEN, ANDERS SEJRMASSACHUSETTS INSTITUTE OF TECHNOLOGYDynamic Bottom-Up Dissection of Chromatin Looping and Gene Regulation
HAROUSH, KERENSTANFORD UNIVERSITYUnraveling Neuronal Circuits and Causal Underpinnings of Long Time-Scale Social Strategic Behaviors
HEKSTRA, DOEKE ROMKEHARVARD UNIVERSITYIdentifying Principles of Protein Mechanics by Applying Force and Observing Motion
HULTMAN, RAINBOUNIVERSITY OF IOWAElectrical Connectomics: An Innovative Approach for Dissecting Brain Mechanisms Underlying Behavioral States
JAISWAL, SIDDHARTHASTANFORD UNIVERSITYClonal Hematopoiesis in Human Aging and Disease
KAO, JONATHAN CHAU-YANUNIVERSITY OF CALIFORNIA LOS ANGELESNext Generation Brain-Machine Interfaces Controlled Synergistically with Artificial Intelligence
KIM, SUNG SOOUNIVERSITY OF CALIFORNIA SANTA BARBARANeural Circuit Mechanisms Underlying Dynamic Stimulus Selection
KUZUM, DUYGUUNIVERSITY OF CALIFORNIA, SAN DIEGOE-Organoids: Functional Brain Organoids Co-Grafted with Transparent Microthreads
LARIMER, BENJAMIN MUNIVERSITY OF ALABAMA AT BIRMINGHAMSite-Specific Immune Cell Activation Detection for Improving Individualized Cancer Immunotherapy
LEE, EUNJUNG ALICEBOSTON CHILDREN'S HOSPITALMechanism for Endogenous Retroelements to Mimic Ancient Exogenous Identities in Aging and Diseased Human Tissue
LI, YANRANUNIVERSITY OF CALIFORNIA RIVERSIDEReprogramming Plant Perception for Novel Plant Natural Products Discovery
LIEBERMAN, TAMI DMASSACHUSETTS INSTITUTE OF TECHNOLOGYAn Evolutionary Framework for Identifying Determinants of Colonization in Human Microbiomes
LONGDEN, THOMAS AUNIVERSITY OF MARYLAND BALTIMOREVascular Signaling Plasticity - Novel Concepts and Tools for Studying Neurovascular Interactions in Health and Disease
MILLER, MILES AMASSACHUSETTS GENERAL HOSPITALDissection of In Situ Myeloid Signaling Using Image-Guided Synthetic Control
MIRI, JOSEPH ANDREWNORTHWESTERN UNIVERSITCombining Physiological, Genetic, and Computational Approaches with Naturalistic Climbing Behavior to Elucidate the Functional Elements of Descending Motor Control
MIRZADEH, ZAMANST. JOSEPH'S HOSPITAL AND MEDICAL CENTERHypothalamic Neurocircuit Remodeling to Treat Diabetes
NAIK, SHRUTINEW YORK UNIVERSITY SCHOOL OF MEDICINEDecoding Microbe-Epithelial Stem Cell Interactions in Health and Disease
NORMAN, THOMAS MAXWELLSLOAN-KETTERING INST CAN RESEARCHPredictive Engineering of Cellular Transcriptional State
PAREDES, MERCEDESUNIVERSITY OF CALIFORNIA, SAN FRANCISCOGyrencephalic Model for Neurodevelopmental Disease and Postnatal Cortical Therapeutic Interventions
RACKI, LISA RSCRIPPS RESEARCH INSTITUTEUsing Phage to Interrogate Bacterial Heterochromatin
ROCKLIN, GABRIEL JACOBNORTHWESTERN UNIVERSITY AT CHICAGOHigh-Throughput Discovery of Protein Energy Landscapes in Natural and Designed Proteomes
ROHNER, NICOLASSTOWERS INSTITUTE FOR MEDICAL RESEARCHStarvation Resistance and Resilience of Metabolic Dysfunction in Cavefish
SANCAK, YASEMIN SUNIVERSITY OF WASHINGTONMolecular Dissection of Mitochondria-Organelle Interactions
SCHMIDT, JENS CHRISTOPHERMICHIGAN STATE UNIVERSITYSingle-Molecule Analysis of the DNA Damage Response in Living Cells
SHANECHI, MARYAMUNIVERSITY OF SOUTHERN CALIFORNIAA Novel Geometric Paradigm for Nonlinear Modeling and Control of Neural Dynamics
SHIPMAN, SETH LAWLERJ. DAVID GLADSTONE INSTITUTESEngineered Mitochondria for Therapeutic Donation and Mitochondrial Genome Editing
SPEER, COLENSO MCNAUGHTONUNIV OF MARYLAND, COLLEGE PARKA Molecular Connectomics Platform for Multi-Scale Analysis of Activity-Dependent Synapse Development and Plasticity
STERNBERG, SAMUEL HENRYCOLUMBIA UNIVERSITY HEALTH SCIENCESLeveraging Programmable Integrases for Human Genome Engineering
STITES, EDWARD CSALK INSTITUTE FOR BIOLOGICAL STUDIESSystems Approaches for Opening Therapeutic Windows
TAKEBE, TAKANORICINCINNATI CHILDRENS HOSP MED CTREngineering Multi-Organs in a Dish
WANG, KAIHANGCALIFORNIA INSTITUTE OF TECHNOLOGYMegabase Scale Genome Engineering and Synthesis in Mammalian Cells
WEI, LUCALIFORNIA INSTITUTE OF TECHNOLOGYSuper-Resolution Chemical Imaging for Biomedicine
WHITE, KATHARINE ALICEUNIVERSITY OF NOTRE DAMERoles for Increased Intracellular pH and Heterogeneity in Cancer
WU, XUEBINGCOLUMBIA UNIVERSITY HEALTH SCIENCESGenome-Wide Studies of the Noncoding Functions and Mechanisms of Human mRNAs
YAN, KELLEYCOLUMBIA UNIVERSITY HEALTH SCIENCESDirecting Cell Fate Along the Intestinal Enteroendocrine Lineage
YE, LISCRIPPS RESEARCH INSTITUTEModulating Somatosensory Network to Target Metabolic Diseases
ZHU, BOKAIUNIVERSITY OF PITTSBURGH AT PITTSBURGHDecoding The Regulation and Functions of Mammalian 12h-Clock

2019 NIH Director's New Innovator Award (DP2) (RFA-RM-18-008)

*Advisory Committee to the NIH Director Working Group Findings

PI NameInstitution NameTitle
AKBARI, OMAR SULTANUNIVERSITY OF CALIFORNIA, SAN DIEGODevelopment of Synthetic Viral Circuitry to Regulate Viruses in Mosquito Disease Vectors
BEIER, KEVIN TUNIVERSITY OF CALIFORNIA-IRVINESculpting the Brain: High-Resolution Spatiotemporally-Controlled Modulation of Memories
BEYDER, ARTHURMAYO CLINIC ROCHESTERDoes the Gut Have a Sense of Touch?
BOHORQUEZ, DIEGO VDUKE UNIVERSITYReversing Autism Linked Behaviors from the Gut
BUENROSTRO, JASON DANIELHARVARD UNIVERSITYSingle-Cell Epigenomic and Cellular Plasticity
BULLER, ANDREWUNIVERSITY OF WISCONSIN-MADISONEngineering In Vivo Biomolecular Synthesis with Non-Standard Building Blocks
CAI, DENISE JADEICAHN SCHOOL OF MEDICINE AT MOUNT SINAIHow Does the Brain Maximize Storage Capacity?
CARMONA-FONTAINE, CARLOSNEW YORK UNIVERSITYDecoding the Fundamental Mechanisms of Tumor Emergence and Evolution
CARVUNIS, ANNE-RUXANDRAUNIVERSITY OF PITTSBURGH AT PITTSBURGHFrom Non-Coding to Coding: Uncovering the Hidden Coding Potential of Non-Coding Sequences and Its Role in De Novo Gene Evolution
CHANG, RUIYALE UNIVERSITYUnderstand the Little Brain on the Heart: A Molecular and Functional Dissection of the Intrinsic Cardiac Nervous System
DAYEH, SHADIUNIVERSITY OF CALIFORNIA, SAN DIEGOBringing Light to Functional Mapping in Resective Neurosurgery
DEANS, TARA LYNNUNIVERSITY OF UTAHEngineered Platelets for the Targeted Destruction of Circulating Tumor Cells
DIONNE, JENNIFER ASTANFORD UNIVERSITYNano-Optical Reporters of Dynamic Mechanotransduction in the Immune System
DOWNING, TIMOTHY LAMONTUNIVERSITY OF CALIFORNIA-IRVINESpatial Epigenomics: A New Framework for Overcoming Mechanical Heterogeneity in Solid Tumors
DUPAGE, MICHELUNIVERSITY OF CALIFORNIA BERKELEYEngineering Precision Cancer Immunotherapy
EDLOW, BRIAN LMASSACHUSETTS GENERAL HOSPITALA Connectome-Based Clinical Trial Platform to Promote Early Recovery of Consciousness After Traumatic Coma
FATTAHI, FARANAKUNIVERSITY OF CALIFORNIA, SAN FRANCISCOModeling Neurodegenerative Disease Manifestations in Human Enteric Neurons
GREER, PAUL LIEBERMANUNIV OF MASSACHUSETTS MED SCH WORCESTERElucidating the Role of a Novel Family of Chemoreceptor in Alzheimers Disease
GUO, CHUN-JUNWEILL MEDICAL COLL OF CORNELL UNIVAn Integrative and Generalizable Approach to Modulate Microbiota Small Molecules in the Host
GUPTA, RAJAT MBRIGHAM AND WOMEN'S HOSPITALA Genetic Approach to Identify the Common Mechanisms of Vascular Disease
KLOXIN, APRIL MUNIVERSITY OF DELAWAREUnraveling Fibrosis with Dynamic Microenvironments and Molecular Tools
KOCHER, SARAH DPRINCETON UNIVERSITYWhat Makes - and Breaks - a Social Brain?
LEGANT, WESLEY RUNIV OF NORTH CAROLINA CHAPEL HILLConnecting the Dots Between Single Molecule Dynamics and Cell Differentiation
LEIFER, ANDREW MICHAELPRINCETON UNIVERSITYProbing Brain-Wide Functional Connectivity During Behavior
LERNER, TALIA NEWCOMBENORTHWESTERN UNIVERSITY AT CHICAGOHow Early-Life Experiences Create Individual Variation in Dopamine Circuit Architecture: Understanding Risk for Psychiatric Disease
LEVY, MAAYANUNIVERSITY OF PENNSYLVANIAPost-Biotic Interventions to Ameliorate Age-Related Inflammation
LI, HANUNIVERSITY OF CALIFORNIA-IRVINEEngineering an Unnatural Redox Cofactor (Uredox) System for Efficient Biosynthesis of Medicines
LIAU, BRIANHARVARD UNIVERSITYMapping Structure-Activity Relationships of Chemical Inhibitors Via Genome-Editing
LUEDTKE, ALEXUNIVERSITY OF WASHINGTONHigh-Resolution Inference for Correlates of Vaccine Protection
MCCORMICK, TYLERUNIVERSITY OF WASHINGTONBig Data, Big Models, and Big Bias?: A Decision Making Framework for Vital Rate Estimates Based on Extrapolation
MOHIMANI, HOSEINCARNEGIE-MELLON UNIVERSITYDiscovering Novel Small Molecule Antibiotics from Complex Microbial Communities by Integrating Computational Mass Spectrometry and Metagenome Mining
MORIZANE, RYUJIMASSACHUSETTS GENERAL HOSPITALRecreating Kidney Organogenesis In Vitro with Human Pluripotent Stem Cells
MUZUMDAR, MANDAR DEEPAKYALE UNIVERSITYDefining Tumor Cell and Host Adaptations in Cancer Progression
NIU, JIABOSTON COLLEGEDevelopment of Compact CRISPR Editors for Multiplexed Editing of Complex Gene Networks
O'CONNELL, LAUREN ASTANFORD UNIVERSITYDietary Tuning of Infant Social Communication
OLABISI, OPEYEMI AYODEJIDUKE UNIVERSITYA Human Stem Cell-Derived Podocyte Model for APOL1 Nephropathy
PALM, NOAH WOLCOTTYALE UNIVERSITYA Forward Chemical Genetic Screen to Illuminate the Dark Matter of the Bioactive Microbiota Metabolome
PERANTEAU, WILLIAM HCHILDREN'S HOSP OF PHILADELPHIAIn Utero CRISPR-Mediated Gene Editing to Cure Congenital Monogenic Disorders
POLLEN, ALEXANDER AUNIVERSITY OF CALIFORNIA, SAN FRANCISCOEstablishing a Stem Cell Biology Platform for Decoding the Genetic Basis of Human Brain Specializations
POULOPOULOS, ALEXANDROSUNIVERSITY OF MARYLAND BALTIMOREUntangling the Biology of Brain Wiring: High-Throughput Innovations for Molecular Screening and Functional Targeting of Circuit Development In Vivo
PUA, HEATHER HVANDERBILT UNIVERSITY MEDICAL CENTERExtracellular RNA Communication in Lung Inflammation
RAKOFF-NAHOUM, SETHBOSTON CHILDREN'S HOSPITALPositive Selection as a Host Mechanism to Control the Microbiome
RUNYAN, CAROLINE ANNEUNIVERSITY OF PITTSBURGH AT PITTSBURGHCommunication Between Networks: Context, Inhibition, and Neuromodulation
SCHUG, ZACHARYWISTAR INSTITUTEThe Multifaceted Role of Acetate in Cancer
SCHWARZ, LINDSAY AST. JUDE CHILDREN'S RESEARCH HOSPITALIntersectional Strategies to Understand the Function of Diverse Neural Circuits
SHALEM, OPHIRCHILDREN'S HOSP OF PHILADELPHIADirect and Rapid Control of Proteins at Scale
SHAO, SICHENHARVARD MEDICAL SCHOOLDecoding Ribosome-Triggered Quality Control Mechanisms
SHARMA, UPASNAUNIVERSITY OF CALIFORNIA SANTA CRUZPaternal Contributions to Offspring Health: Intergenerational Epigenetic Inheritance Via Sperm Small RNAs
SIMOES-COSTA, MARCOSCORNELL UNIVERSITYSpatial Control of Pattern Formation in Early Vertebrate Development
SMITH, CODY JUNIVERSITY OF NOTRE DAMEAn Integrative Approach to Elucidate Glial Diversity and Its Role in Brain Functionality
TAGLIABRACCI, VINCENT SCOTTUT SOUTHWESTERN MEDICAL CENTERBreathing Life into Dead Enzymes
THAISS, CHRISTOPH ALEXANDERUNIVERSITY OF PENNSYLVANIAA Conserved Function of Amyloid Proteins in Host-Microbiome Interactions
THEUNISSEN, THOROLDWASHINGTON UNIVERSITYResolving Epigenetic Instability During Pluripotent State Transitions: A Roadmap for Exploiting the Biomedical Potential of Dynamic Human Stem Cell States
VEDANTHAM, VASANTHUNIVERSITY OF CALIFORNIA, SAN FRANCISCOA Regenerative Approach to Cardiac Pacing
VILLANI, ALEXANDRA-CHLOEMASSACHUSETTS GENERAL HOSPITALDeciphering the Achilles Heel of Cancer Immunotherapy
VOORHEES, REBECCA MARIACALIFORNIA INSTITUTE OF TECHNOLOGYProtein Complex Assembly in the ER Membrane
WANG, SIYUANYALE UNIVERSITYBuilding the 3D Genomic Regulatome
WON, HYEJUNGUNIV OF NORTH CAROLINA CHAPEL HILLDeciphering Cell-Type Specific Regulatory Landscape in Human Brain
YUEN, COURTNEY MINGMENBRIGHAM AND WOMEN'S HOSPITALNew Approaches to Optimizing the Application and Measuring the Impact of Community-Based Tuberculosis Interventions
ZHANG, XIAOCHANGUNIVERSITY OF CHICAGOSingle Cell Detection of Dynamic Protein-RNA Interaction

 

2018 NIH Director's New Innovator Award (DP2) (RFA-RM-17-006)

*Commitment to Diversity

PI NameInstitution NameTitle
BOETTIGER, ALISTAIRSTANFORD UNIVERSITYHigh Resolution Imaging of Genome Structure and Gene Regulation in Development
CARVILL, GEMMA LOUISENORTHWESTERN UNIVERSITY AT CHICAGOCell-Free DNA Sequencing Approaches to Define the Genetic Etiology of Unexplained Epilepsy
CHEN, JERRY LBOSTON UNIVERSITY (CHARLES RIVER CAMPUS)Cracking Genetically Defined Neocortical Circuits across Learning and Behavior
CHEN, SIDIYALE UNIVERSITYHigh-Throughput In Vivo Genetics for Immunotherapy Target Discovery
CHEVRIER, NICOLASUNIVERSITY OF CHICAGOBuilding a Predictive Framework for Adjuvant Combinatorics in Vaccine Development
CHUNG, EUN JIUNIVERSITY OF SOUTHERN CALIFORNIAA Revolutionary Approach for Polycystic Kidney Disease: Oral Nanotherapeutics
DENNIS, MEGAN YUNIVERSITY OF CALIFORNIA AT DAVISThe Function of Duplicated Genes in Human Brain Evolution and Disease
DONALDSON, ZOE REBECCAUNIVERSITY OF COLORADONeuronal Basis of Social Motivation and the Failure to Adapt to Loss
DOULATOV, SERGEIUNIVERSITY OF WASHINGTONUncovering Epigenetic Barriers to Hematopoietic Stem Cell Formation
DUTTON, RACHEL JUNIVERSITY OF CALIFORNIA, SAN DIEGOMolecular Mechanisms that Shape Microbial Communities
EHRLICH, KATHERINE BABCOCKUNIVERSITY OF GEORGIAInnovative Approaches to the Study of Social Determinants of Health in Children
FEINBERG, EVAN HARRIMANUNIVERSITY OF CALIFORNIA, SAN FRANCISCOHigh-Resolution Neural Circuit Dissection with Controllers Locally Affecting Synaptic Partners (CLASP)
FLOOR, STEPHEN NICHOLASUNIVERSITY OF CALIFORNIA, SAN FRANCISCOThe Impact of Human RNA Diversity on Protein Production and Cell Fate
FREDERICK, KENDRA KINGUT SOUTHWESTERN MEDICAL CENTERHigh Sensitivity NMR for Structure Determination of Neurodegenerative Disease Associated Protein Aggregates in Native Contexts
GALLEGO-PEREZ, DANIELOHIO STATE UNIVERSITYNovel Nanoscale Approaches to Whole Tissue Reprogramming
GAWAD, CHARLESST. JUDE CHILDREN'S RESEARCH HOSPITALCreating a Catalog of Cancer Clonotype Drug Sensitivities with Single-Cell Genome Sequencing
GILBERT, LUKEUNIVERSITY OF CALIFORNIA, SAN FRANCISCOA Genetic Interaction Map of the Human Nucleus
GONG, YIYANGDUKE UNIVERSITYVoltage Imaging Dissection of the Mammalian Cortex
GORDON, REYNA LEIGHVANDERBILT UNIVERSITY MEDICAL CENTERBiomarkers of Rhythmic Communication: Integrating Foundational and Translational Approaches
GUO, JUNJIEYALE UNIVERSITYMolecular and Cellular Determinants of RNA Repeat-Associated Properties
HARIADI, RIZAL FAJARARIZONA STATE UNIVERSITY-TEMPE CAMPUSNanoscale Reconstruction of Mechanical Systems Involved in Disease Pathogenesis
HUANG, JUNUNIVERSITY OF CHICAGOMolecular Mechanism of Natural Killer Cell Recognition
JAIN, RAJANUNIVERSITY OF PENNSYLVANIADeciphering Nuclear Lamina-Chromatin Organization in Cellular Competence and Cardiac Development
KAYSER, MATTHEW SUNIVERSITY OF PENNSYLVANIABuilding Brains in Our Sleep: A Drosophila Larval Platform for Examining Sleep and Neurogenesis
KIM, JUSTINDANA-FARBER CANCER INSTPost-Translational Modification of Protein Surfaces
KING, KEVIN RUNIVERSITY OF CALIFORNIA, SAN DIEGOElucidating Cell Communication Networks During Tissue Inflammation, Fibrosis, and Regeneration
KWON, ESTER JUNIVERSITY OF CALIFORNIA, SAN DIEGONanoscale Biomaterials for Targeted Repair in Traumatic Brain Injury
LANDAU, DANWEILL MEDICAL COLL OF CORNELL UNIVShapeshifters in Cancer: Defining the Fundamental Forces of Leukemia Evolution
LIU, SHIXINROCKEFELLER UNIVERSITYProbing Symmetry Breaking in Epigenetic Inheritance: From Single Molecules to Systems Biology
LOH, PO-RUBRIGHAM AND WOMEN'S HOSPITALRevealing Somatic Genome Alterations and Their Clinical Sequelae: Ultrasensitive Computational Detection of Mosaic Structural Variants
MCBRIDE, CAROLYN SARAHPRINCETON UNIVERSITYMapping the Combinatorial Olfactory Inputs that Drive Mosquito Host Attraction
MISHRA, PRASHANTUT SOUTHWESTERN MEDICAL CENTEREngineering Faithful Animal Models of Mitochondrial Disease
MITCHELL, MICHAEL JUNIVERSITY OF PENNSYLVANIAA Data-Driven Drug Delivery (4D) Platform for Probing and Treating the Chemoresistant Bone Marrow Microenvironment
MOORE, DARCIE LEANNUNIVERSITY OF WISCONSIN-MADISONThe Mechanisms and Functional Role of the Asymmetric Segregation of Cellular Cargoes in Stem Cells
PATHAK, MEDHA MUNIVERSITY OF CALIFORNIA-IRVINEBuilding the Brain: How Mechanical Forces Shape Human Neural Development
RAMAN, SRIVATSANUNIVERSITY OF WISCONSIN-MADISONUnderstanding Molecular Rules Governing Protein Allostery by Deep Mutational Scanning
ROCK, JEREMY MICHAELROCKEFELLER UNIVERSITYTowards a Molecular Understanding of Persistent Tuberculosis Infection
ROYBAL, KOLE TUNIVERSITY OF CALIFORNIA, SAN FRANCISCOEngineering the Next-generation of Custom Immune Cell Therapies
RUDER, WARREN CHRISTOPHERUNIVERSITY OF PITTSBURGH AT PITTSBURGHCreating Magnetically Inducible Synthetic Gene Networks for Cell and Tissue Therapies
SAFDAR, NASIAUNIVERSITY OF WISCONSIN-MADISONModelling Applications and Systems Engineering to Reduce Infections the MASTERI Study
SAGGAR, MANISHSTANFORD UNIVERSITYOnly Time Will Tell: A Computational Psychiatry Approach to Model Temporal Transitions in Brain Activity as a Lens Towards Developing Better Diagnostic Nosology for Psychiatric Illness
SCHARSCHMIDT, TIFFANY CRAWFORDUNIVERSITY OF CALIFORNIA, SAN FRANCISCODecoding and Harnessing Microbial Tuning of T Cell Responses in Early Life
SHEFFIELD, MARK E JUNIVERSITY OF CHICAGOSub-Cellular Resolution Functional Imaging and Optogenetic Manipulation of Identified Memory Circuits During Behavior
SLETTEN, ELLEN MAYUNIVERSITY OF CALIFORNIA LOS ANGELESBioorthogonal Host-Guest Chemistry for Tandem Imaging and Therapy
SPENCER, SABRINA LEIGHUNIVERSITY OF COLORADOProliferation-Quiescence Control in Single Cells: Integration of Mitogen, Nutrient, and Stress Signaling
STEPHANOPOULOS, NICHOLASARIZONA STATE UNIVERSITY-TEMPE CAMPUSChemical Synthesis of G Protein-Coupled Receptors Using Sequential DNA-Templated Reactions
TADROSS, MICHAEL RDUKE UNIVERSITYInterrogating Dynamics of Whole-Brain Volumes with Cell Type-Specific Pharmacology
TITOV, DENIS VASILIEVICHUNIVERSITY OF CALIFORNIA BERKELEYGenetically Encoded Tools for Manipulation of Metabolism In Vivo
TOMER, RAJUCOLUMBIA UNIV NEW YORK MORNINGSIDEA Comparative Approach for Decomposing the Mammalian Brain Architectural Complexity
VARGAS-IRWIN, CARLOSBROWN UNIVERSITYSynergistic Effector/Environment Encoding: A New Perspective on Motor Cortex and Brain-Computer Interfaces
WATANABE, SHIGEKIJOHNS HOPKINS UNIVERSITYReviving Electron Microscopy for Synaptic Cell Biology
WESOLOWSKI, AMYJOHNS HOPKINS UNIVERSITYDisease Emergence and Elimination: Using Mobility Data to Inform Spatial Disease Dynamics
WHITEHEAD, KATHRYN ACARNEGIE-MELLON UNIVERSITYFate, Function and Genetic Engineering of Breast Milk Cells for Infant Therapy
WRIGHT, ERIK SCOTTUNIVERSITY OF PITTSBURGH AT PITTSBURGHUncovering Synergistic Antibiotic Cocktails with Comparative Genomics
XU, KEUNIVERSITY OF CALIFORNIA BERKELEYIntracellular Phase Separation at the Nanoscale: A Functional Super-Resolution Approach
YAMANAKA, NAOKIUNIVERSITY OF CALIFORNIA RIVERSIDEMembrane Steroid Hormone Transporters in Development and Reproduction
ZANDERS, SARAH ELIZABETHSTOWERS INSTITUTE FOR MEDICAL RESEARCHModels of Selfishness: Molecular and Evolutionary Analyses of the Wtf Meiotic Drivers
ZHAO, YONGXINCARNEGIE-MELLON UNIVERSITYHighly Multiplexed Nanoscale Imaging Platforms for Profiling and Interrogation of Complex Diseases

 

2017 NIH Director's New Innovator Award (DP2) (RFA-RM-16-004)

*Statement on Diversity

PI NameInstitution NameTitle
AJIJOLA, OLUJIMI AUNIVERSITY OF CALIFORNIA LOS ANGELESMultimodal Decoding of the Neural Circuitry of Sudden Death in Peripheral Ganglia
AZIM, EIMANSALK INSTITUTE FOR BIOLOGICAL STUDIESNeural Control of Skilled Movements: An Ethological Dissection of Genetically Tractable Mammalian Motor Circuits
BARMAN, ISHANJOHNS HOPKINS UNIVERSITYSpectroscopy Assisted Mechano-Chemical Phenotype Recognition Nanoscope
BIRSOY, KIVANCROCKEFELLER UNIVERSITYDissecting Tumor Metabolic Heterogeneity In Vivo
BLACKBURN, JESSICA SUNIVERSITY OF KENTUCKYHarnessing Single Cell Technology to Define Self-Renewal in Normal and Malignant Stem Cells
BLAINEY, PAUL CLARKBROAD INSTITUTE, INCLive Cell Transcriptomics
BRITO, ILANA LAURENCORNELL UNIVERSITYSystems-Level Perspectives of Horizontal Gene Transfer Within the Human Microbiome
CALVE, SARAHPURDUE UNIVERSITYDefining the Mechanical Link that Unites the Musculoskeletal System During Limb Development
CAMBRONNE, XIAOLU ANGOREGON HEALTH & SCIENCE UNIVERSITYGatekeepers of Mitochondrial NAD+
CHEN, ZHILEITEXAS A&M UNIVERSITY HEALTH SCIENCE CTRArtificial Ecology Sink as Prophylaxis Against Viral Infection
CHOI, JAEHYUKNORTHWESTERN UNIVERSITY AT CHICAGOIdentifying Mechanisms Governing T Cell Diversity
COLLINS, SEAN RYANUNIVERSITY OF CALIFORNIA AT DAVISRewiring Control of Leukocyte Motility for Therapeutic Application
CORN, JACOB ELLERYUNIVERSITY OF CALIFORNIA BERKELEYDiscovering Mechanisms that Regulate Organelle Autophagy
DE VLAMINCK, IWIJNCORNELL UNIVERSITYPrecision Monitoring of Kidney Transplants Via Single-Cell and Single-Molecule Sequencing
DELGOFFE, GREG MUNIVERSITY OF PITTSBURGH AT PITTSBURGHExploring and Exploiting Metabolic Plasticity in Regulatory T Cells
DERBYSHIRE, EMILY RDUKE UNIVERSITYEnabling Host Processes for Defense Against Liver Stage Malaria Infection
ESVELT, KEVINMASSACHUSETTS INSTITUTE OF TECHNOLOGYDeveloping Powerful Daisy Drive Systems for the Precise Alteration of Local Populations
FARLEY, EMMA KIRSTENUNIVERSITY OF CALIFORNIA SAN DIEGODeciphering the Regulatory Principles Governing Enhancer Specificity
FEI, JINGYIUNIVERSITY OF CHICAGOQuantitative Imaging of Epitranscriptomic Regulation Mediated by RNA Modification
GAHARWAR, AKHILESH KTEXAS ENGINEERING EXPERIMENT STATIONMineralomics: Designing Mineral Based Therapeutics to Control and Direct Cell Function
GARCIA, HERNAN GUSTAVOUNIVERSITY OF CALIFORNIA BERKELEYLighting Up the Central Dogma in Embryonic Development
GREEN, ALEXANDER ARTHURARIZONA STATE UNIVERSITY-TEMPE CAMPUSMolecular Fuses for Real-Time, Label-Free, Multiplexed Imaging of RNAs in Living Cells
HIRES, SAMUEL ANDREWUNIVERSITY OF SOUTHERN CALIFORNIANew Approaches to Understanding Sensorimotor Learning and Perception
HOLLIS, EDMUND RWINIFRED MASTERSON BURKE MED RES INSTModulation of Cortical Networks, a New Approach to Spinal Cord Injury Rehabilitation
HON, GARY CHUNGUT SOUTHWESTERN MEDICAL CENTERCombinatorial Biology of Gene Regulation for Cellular Engineering
HWANG, SEUNGMINUNIVERSITY OF CHICAGOTargeting by Autophagy Proteins for Anti-Tumor Immunity
IVANOVIC, TIJANABRANDEIS UNIVERSITYBuilding Mechanistic Insight into Evolvability of Viral Cell-Entry Functions
KIM, YONGTAEGEORGIA INSTITUTE OF TECHNOLOGYProbing the Functional Heterogeneity of High-Density Lipoprotein Using Physiological Biomimicry
LI, BOUNIV OF NORTH CAROLINA CHAPEL HILLMining Genomes for Synergistic Antibiotics
LI, LINGYINSTANFORD UNIVERSITYChemical Biology of Innate Immunity for Treating Cancer and Autoimmunity
LINOS, ELENIUNIVERSITY OF CALIFORNIA, SAN FRANCISCOTargeted Advertising for Cancer Prevention
MACOSKO, EVAN ZBROAD INSTITUTE, INC.Slide-Seq: High-Resolution In Situ Expression Profiling for Neuropathology
MALVANKAR, NIKHILYALE UNIVERSITYTargeting Bacterial Infections by Imaging Electrical Interactions Between Host Surface Pathogens
MOELLERING, RAYMOND EUNIVERSITY OF CHICAGOTargeting Transcription with Synthetic Biologics
MOLOFSKY, ANNA VUNIVERSITY OF CALIFORNIA, SAN FRANCISCOCoordinate Regulation of Neural Circuit Remodeling by Glia: A Prospective Molecular Approach
MORGAN, DANIEL JUNIVERSITY OF MARYLAND BALTIMOREIncorporating Bayesian Reasoning into Physician Testing and Treatment Decisions
OH, JULIA SJACKSON LABORATORYMetagenomes to Therapeutics: Defining the Rules for Engineering the Skin Microbiome
PANNIER, ANGELA KUNIVERSITY OF NEBRASKA LINCOLNUsing Cell Priming and Telecommunications Modeling to Enhance Gene Delivery for Stem Cell Therapies
RAJASETHUPATHY, PRIYAROCKEFELLER UNIVERSITYBridging the Gap from Genes to Circuits to Behavior in Understanding Cognitive Dysfunction
ROSE, SHERRIHARVARD MEDICAL SCHOOLMachine Learning for Health Outcomes and Quality of Care in Low-Income Populations
SAMUEL, BUCK SPARROWBAYLOR COLLEGE OF MEDICINEMicrobial Programming of Host Physiology
SANJANA, NEVILLENEW YORK GENOME CENTERIn Situ Functional Genomics to UnderstandTranscriptional Regulation
SARMA, KAVITHAWISTAR INSTITUTEEpigenetic Regulation Through the Formation and Resolution of R Loops
SCHIETINGER, ANDREASLOAN-KETTERING INST CAN RESEARCHSpatiotemporal Regulation of T Cell Fate Decisions in Cancer
SCHLAU-COHEN, GABRIELAMASSACHUSETTS INSTITUTE OF TECHNOLOGYNanometer Distance Assay to Uncover Protein Dynamics
SHEEHAN, MICHAEL JCORNELL UNIVERSITYEncoding Knowledge in the Genome
SIEGRIST, MARY SLOANUNIVERSITY OF MASSACHUSETTS AMHERSTChemical Detection of Mycobacterium tuberculosis Growth and Antibiotic Response during Infection
SLUSKY, JOANNA SUNIVERSITY OF KANSAS LAWRENCEDesigned Beta-Strands for Inhibiting Efflux Pumps and Disabling Antibiotic Resistance
SUBRAMANIAN, RADHIKAMASSACHUSETTS GENERAL HOSPITALA Versatile Platform for Reconstructing the Spatial Organization of Intracellular Signaling During Cell-Division
TRITSCH, NICOLAS XAVIERNEW YORK UNIVERSITY SCHOOL OF MEDICINEA Novel Framework for the Functional Dissection of Motor Systems
VON MOLTKE, JAKOBUNIVERSITY OF WASHINGTONSensing of Helminths by Tuft Cells
WAINGER, BRIAN JASONMASSACHUSETTS GENERAL HOSPITALA Human Stem Cell-Derived Neuromuscular Junction Model for Amyotrophic Lateral Sclerosis
WU, HAOUNIVERSITY OF PENNSYLVANIACharting Oxygen-Sensing Gene Regulatory Network in Cardiomyocytes Through Single-Cell Analysis and Epigenome Editing
YANG, HUANGHEDUKE UNIVERSITYManipulating TMEM16F Lipid Scramblase to Understand the Transbilayer Phospholipid Transport Phenomenon
ZHENG, YUEBINGUNIVERSITY OF TEXAS AT AUSTINOn-Chip Multiplexed Adhesion Frequency Assay for Measuring Receptor-Ligand Interactions on Cells

 

2016 NIH Director's New Innovator Award (DP2) (RFA-RM-13-007)

PI NameInstitution NameTitle
AL-SADY, BASSEM UNIVERSITY OF CALIFORNIA, SAN FRANCISCOReconstructing Dynamic Epigenetic Genome Partitioning in Single Stem Cells
ANDREWS, JASON RANDOLPHSTANFORD UNIVERSITYCongregate Air Sampling for Population-Based Detection of Tuberculosis
APOSTOLOU, EFFIEWEILL MEDICAL COLL OF CORNELL UNIVDefining the Role of Chromatin Architecture in Cell Fate Inheritance
BAUER, DANIEL EVANCHILDREN'S HOSPITAL CORPORATIONHigh-Throughput Discovery of Essential Noncoding Sequences for Erythropoiesis
BENDALL, SEAN CURTISSTANFORD UNIVERSITYOrigins of Human Blood Lineages in Regenerative Medicine
BHATNAGAR, PARIJATSRI INTERNATIONALSelf-Assembled Therapeutics with Spatiotemporal Resolution
BROHAWN, STEPHEN GRAFUNIVERSITY OF CALIFORNIA BERKELEYNew Approaches to Understanding Biological Force Sensation
CHEN, IRENE AUNIVERSITY OF CALIFORNIA SANTA BARBARAUnderstanding How Bacteriophages Affect Wound Ecologies and Developing New Tools to Harness Bacteria-Phage Interactions
CHIU, ISAAC MING-CHENGHARVARD MEDICAL SCHOOLSensory Neuron-Bacteria Interactions in Modulating Pain and the Host Microbiota
CHUNG, KWANGHUNMASSACHUSETTS INSTITUTE OF TECHNOLOGYProteome-Driven Holistic Reconstruction of Organ-Wide Multi-Scale Networks
CRAWFORD, FORREST WRENNYALE UNIVERSITYNetwork-Based Epidemiology for Hidden and Hard-to-Reach Populations
CRUM, ALIASTANFORD UNIVERSITYHarnessing Mindset in 21st Century Healthcare
DUS, MONICAUNIVERSITY OF MICHIGANThe Role of Neuroepigenetics in Bidirectional Behavioral States
EGAN, ELIZABETH SSTANFORD UNIVERSITYIdentifying Critical Erythrocyte Host Factors for Plasmodium falciparum Malaria
FORDYCE, POLLY MORRELLSTANFORD UNIVERSITYLeveraging Spectral Encoding for High Dimensional Biological Multiplexing
GREER, ERIC LIEBERMANCHILDREN'S HOSPITAL CORPORATIONCharacterization of DNA N6-Methyl Adenine and Its Role in Epigenetic Memory
GUO, SHANGQINYALE UNIVERSITYMolecular Definition of Cancer Cell-of-Origin
HAMMOUD, SAHER SUEUNIVERSITY OF MICHIGANContributions of Sperm Chromatin to Development: A Myth or Reality?
JOKERST, JESSE VINCENTUNIVERSITY OF CALIFORNIA SAN DIEGOTherapeutic Drug Monitoring with a Wearable Ultrasound-Based Sensor
KHALIL, AHMAD SAMIRBOSTON UNIVERSITY (CHARLES RIVER CAMPUS)Combatting Antibiotic Resistance with Synthetic Biology Technologies
KLINGE, SEBASTIANROCKEFELLER UNIVERSITYTrapping and Reconstituting Early Stages of Eukaryotic Ribosome Assembly
KOREN, AMNONCORNELL UNIVERSITYPersonal Mutational Landscapes Encoded in Our DNA
KRALJ, JOEL MARKUNIVERSITY OF COLORADONeuronal Electromics in Health and Disease
KUNDAJE, ANSHULSTANFORD UNIVERSITYDeep Learning Frameworks for Regulatory Genomics
KWONG, GABRIEL AGEORGIA INSTITUTE OF TECHNOLOGYNoninvasive and Predictive Biomarkers of Organ Transplant Rejection
LAGANOWSKY, ARTHUR DTEXAS A&M UNIVERSITY HEALTH SCIENCE CTRNative Ion Mobility Mass Spectrometry Studies of Potassium Inward Rectifier Channels: Insight into Gating and Lipid Binding
LEAL, CECILIAUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGNA New Paradigm in Nanomedicine: Can Structural Interiors of Nanoparticles Regulate Cellular Delivery?
MADHUR, MEENAKSHI SWAMINATHANVANDERBILT UNIVERSITYImmunophenotyping of Human Hypertension Using Single Cell Multiplex Mass Cytometry to Identify Novel Therapeutic Targets
NAIR, NIKHIL UNNITUFTS UNIVERSITY MEDFORDMetabolic Engineering in Humans: Altered Gut Microbes as a Therapeutic Platform
PENG, TIENUNIVERSITY OF CALIFORNIA, SAN FRANCISCODefining the Resident Mesenchymal Stem Cell Niche and Function In Vivo
PERERA, RUSHIKA MIRIAMUNIVERSITY OF CALIFORNIA, SAN FRANCISCOTracking Tumor Evolution Through In Vivo Organelle Profiling
PETRY, SABINEPRINCETON UNIVERSITYBuilding the Chromosome Segregation Machinery from Scratch
PURVIS, JEREMYUNIV OF NORTH CAROLINA CHAPEL HILLControlling Stem Cell Fate Through Computational Modeling
ROGULJA, DRAGANAHARVARD MEDICAL SCHOOLMechanisms of Arousal Threshold and Sleep Homeostasis
SAMUEL, MELANIE ABAYLOR COLLEGE OF MEDICINESynaptic Reprogramming of Adult Neurons
SATIJA, RAHULNEW YORK GENOME CENTERLearning the Metadata of the Cell with Single Cell Genomics
SCHMIDT, TIFFANY MNORTHWESTERN UNIVERSITYGenetic Mapping of Visual Circuits
SLAVOV, NIKOLAI NORTHEASTERN UNIVERSITYRibosome-Mediated Translational Regulation during Stem Cell Differentiation
STAUFFER, WILLIAM RICHARDUNIVERSITY OF PITTSBURGH AT PITTSBURGHNeural Correlates of Optimal Value Seeking in the Reward System
STEINHAUSER, MATTHEWBRIGHAM AND WOMEN'S HOSPITALA New Modality to Image Tumor Metabolic Heterogeneity at Subcellular Resolution
STEVENS, KELLY RUNIVERSITY OF WASHINGTONThermogenetic Activation of Engineered Tissue for Cardiac Repair
TIAN, BOZHIUNIVERSITY OF CHICAGOSilicon-Based Injectable Micro-Gels for Non-Genetic and Wireless Modulation of Neurons, Cardiomyocytes and Neuromuscular System
TOETTCHER, JARED EPRINCETON UNIVERSITYHarnessing Optogenetics to Diagnose and Therapeutically Rewire Cancer Cell Signaling
UNAL, ELCINUNIVERSITY OF CALIFORNIA BERKELEYIlluminating Cellular Aging Pathways Through Gametogenesis
VILLA, ELIZABETHUNIVERSITY OF CALIFORNIA SAN DIEGOOpening Windows into the Cell: Revealing the Molecular Architecture of the Nuclear Periphery
WIITA, ARUN PUNIVERSITY OF CALIFORNIA, SAN FRANCISCOIn Vivo Monitoring of Oxidative Protein Folding Through Time-Resolved Quantitative Mass Spectrometry
XUE, WENUNIV OF MASSACHUSETTS MED SCH WORCESTERCRISPR-Based Modular Therapy for Precision Medicine
YARTSEV, MICHAEL MOSHEUNIVERSITY OF CALIFORNIA BERKELEYThe First Mammalian Model System for Studying Vocal Learning: A Behavioral and Neurophysiological Approach

 

2015 NIH Director's New Innovator Award (DP2) (RFA-RM-13-007)

PI NameInstitution NameTitle
BARNES, ALEXANDER BENJAMINWASHINGTON UNIVERSITYHigh-Sensitivity NMR at Room Temperature for Molecular Structure and Dynamics
BARSKI, ARTEMCINCINNATI CHILDRENS HOSP MED CTRDirect Epigenetic Reprogramming of T Cells
BASU, SANJAYSTANFORD UNIVERSITYCohort Filtering Models to Identify Social Program Effects on Health Disparities
BENNETT, ERIC JOSEPHUNIVERSITY OF CALIFORNIA SAN DIEGOManipulating Protein Homeostasis Through Specialized Quality Control Ribosomes
BLOODGOOD, BRENDA LUNIVERSITY OF CALIFORNIA SAN DIEGOCharting a New Path for Rapid Signaling from the Synapse to the Nucleus
BRAR, GLORIA ANNUNIVERSITY OF CALIFORNIA BERKELEYDissecting the Roles of Pervasive Short ORFs in Meiosis
COLE, FRANCESCAUNIVERSITY OF TX MD ANDERSON CAN CTRMechanistic Derivation of Germ Line Mutation by Genome-Wide Mouse Tetrad Analysis
DONIA, MOHAMED ABOUPRINCETON UNIVERSITYUncultivated Bacterial Symbionts of Humans: An Untapped Resource for Drug Discovery
DUMONT, SOPHIEUNIVERSITY OF CALIFORNIA, SAN FRANCISCORewiring Cellular Architecture to Probe Mechanical Signal Processing at Kinetochores
FELDMAN, JESSICA LYNNSTANFORD UNIVERSITYMechanisms Controlling Microtubule Organization during Cell Differentiation
FENG, LIANGSTANFORD UNIVERSITYMolecular Mechanism and Novel Therapeutic Strategy in Alzheimers Disease
GANGULY, KARUNESHUNIVERSITY OF CALIFORNIA, SAN FRANCISCONeuroprosthetic Control of an Anthropomorphic Exoskeleton in Tetraplegics
GERSHOW, MARC HERMANNEW YORK UNIVERSITYDissecting Olfactory Decision Making Using Optical Neurophysiology
GODULA, KAMILUNIVERSITY OF CALIFORNIA SAN DIEGOIn Vivo Glycan Engineering at the Cell-Matrix Interface to Control Stem Cell Fate
GOLDBERG, JESSE HEYMANNCORNELL UNIVERSITYIdentifying Pathways for Motor Variability in the Mammalian Brain
IDOYAGA, JULIANASTANFORD UNIVERSITYHarnessing Human Dendritic Cell Subsets for the Design of Novel Immunotherapies
JAROSZ, DANIELSTANFORD UNIVERSITYProtein-Based Molecular Memories in Gene Regulation, Disease, and Development
JENSEN, JAKOB DANIELUNIVERSITY OF UTAHCommunal Feedback as an Innovative Alternative to Skin Self-Exam
JONIKAS, MARTIN CASIMIRCARNEGIE INSTITUTION OF WASHINGTON, D.C.Transforming Our Understanding of Eukaryotic Gene Functions Through Chemical Genetics in the Green Alga Chlamydomonas reinhardtii
KAMPMANN, MARTINUNIVERSITY OF CALIFORNIA, SAN FRANCISCORewiring of the Human Protein Homeostasis Network in Normal and Disease Contexts
KNIGHT, ZACHARY AUNIVERSITY OF CALIFORNIA, SAN FRANCISCOSequencing Neural Circuits Controlling Thermoregulation
LIPOMI, DARREN JUNIVERSITY OF CALIFORNIA SAN DIEGOStretchable, Biodegradable, and Self-Healing Semiconductors for Wearable and Implantable Sensors
LIU, CHANG CUNIVERSITY OF CALIFORNIA-IRVINEA High-Throughput Continuous Evolution System for In Vivo Biosensor Engineering
MOHAN, DEEPIKAUNIVERSITY OF PITTSBURGH AT PITTSBURGHA Novel Intervention to Make Heuristics a Source of Power for Physicians
MUNRO, JAMES BTUFTS UNIVERSITY BOSTONStructural Dynamics of Single Ebolavirus GP Molecules
PASZEK, MATTHEW JCORNELL UNIVERSITYMechanobiology of the Cellular Glycocalyx
PHILLIPS-CREMINS, JENNIFER ELIZABETHUNIVERSITY OF PENNSYLVANIAEngineering 3-D Epigenome Topology with Light
PRAKASH, MANUSTANFORD UNIVERSITYMosquitoes Meet Microfluidics: Novel Tools for Ecological Surveillance of Insect-Borne Disease
PRASAD, ABHISHEKUNIVERSITY OF MIAMI CORAL GABLESSpinal Cord Neural Interface for Neuroprosthetics in a Primate Model
SCHWARTZ, GREGORY WILLIAMNORTHWESTERN UNIVERSITY AT CHICAGONovel Circuit Mapping Strategies to Reverse Engineer the Retina
SCOTT, EVAN ANORTHWESTERN UNIVERSITYDevelopment of Combination Immunotherapies for Atherosclerotic Inflammation
SEYEDSAYAMDOST, MOHAMMAD RPRINCETON UNIVERSITYImplementing Innovative Approaches to Access the Hidden Metabolomes of Bacteria
SHALEK, ALEX KMASSACHUSETTS INSTITUTE OF TECHNOLOGYBottom - Up Profiling of Interacting Cellular Systems 
SHOULDERS, MATTHEW DONALDMASSACHUSETTS INSTITUTE OF TECHNOLOGYContinuous Directed Evolution of Biomolecules in Human Cells for Medical Research 
SPITALE, ROBERT CUNIVERSITY OF CALIFORNIA-IRVINECracking the RNA Localization Code
TRAPNELL, BRUCE COLSTONUNIVERSITY OF WASHINGTONCharting the Regulatory Topography of the Cell Differentiation Landscape with Single-Cell RNA-Seq
VASEGHI, MARMARUNIVERSITY OF CALIFORNIA LOS ANGELESCardiac Afferent Neurotransmission and Modulation of Ventricular Parasympathetic Control
WARDEN, MELISSA RHOADSCORNELL UNIVERSITYImaging the Evolving Neural Circuit Dynamics of Depression
WHITED, JESSICA LBRIGHAM AND WOMEN'S HOSPITALLeveraging Single-Cell Analysis to Elucidate Mechanisms of Vertebrate Limb Regeneration
YU, MINUNIVERSITY OF SOUTHERN CALIFORNIADeveloping Individualized Medicine Targeting Metastatic Breast Cancer Stem Cells
ZHANG, WENJUNUNIVERSITY OF CALIFORNIA BERKELEYIn Situ Natural Product Labeling and Applications

 

2014 NIH Director's New Innovator Award (DP2) (RFA-RM-13-007)

PI NameInstitution NameTitle
ABATE, ADAM RUNIVERSITY OF CALIFORNIA SAN FRANCISCOMicrofluidic Immunoprofiling for Biomarker Discovery in Rheumatoid Arthritis
ACAR, MURAYALE UNIVERSITYQuantitative Real-Time Characterization of Single-Cell Aging: From Phenotypes to Lifespan
ANDE, SATYANARAYANAGEORGIA REGENTS UNIVERSITY CANCER CENTERA Multifaceted Approach to Target Obesity
ANDERMANN, MARK LBETH ISRAEL DEACONESS MEDICAL CENTERMultiphoton Imaging of Thoughts of Food during Natural and Induced Hunger States
ANTHONY, ROBERT MCCULLOUGHHARVARD MEDICAL SCHOOLGlycoengineering In Vivo 
ARDEHALI, REZAUNIVERSITY OF CALIFORNIA LOS ANGELESExploring Heterogeneity of Cardiac Fibroblasts to Reverse Fibrosis
ARORA, MANISHICAHN SCHOOL OF MEDICINE AT MOUNT SINAIReconstructing Fetal Toxicant Exposure and Homeostatic Disruptions
AYE, YIMONCORNELL UNIVERSITYDeconvoluting Redox Biology with Targeted Chemistry
BASSIK, MICHAEL CSTANFORD UNIVERSITYAccelerating Drug Development and Repurposing Using Systematic Genetic Interaction Maps in Mammalian Cells
BONASIO, ROBERTOUNIVERSITY OF PENNSYLVANIAStudying Epigenetic Pathways in Brain Function and Social Behavior Using Ants
BORAD, MITESHMAYO CLINIC ARIZONAOncolytic Virotherapy in Hepatocellular Cancer
BUSCHMAN, TIMOTHY JPRINCETON UNIVERSITYDeveloping an Adaptive Cognitive Prosthetic to Replace Damaged Brain Regions
CANG, HUSALK INSTITUTE FOR BIOLOGICAL STUDIESUltra Sensitive Single Molecule Spectroscopy with Plasmonic Antennas 
CISSE, IBRAHIMMASSACHUSETTS INSTITUTE OF TECHNOLOGYImaging Transcription with Single Molecule Resolution in Live Mammalian Cells
COBEY, SARAHTHE UNIVERSITY OF CHICAGOModeling the Evolutionary Dynamics of Immunity to Influenza for Vaccine Development
GARNER, ETHAN CLARKHARVARD UNIVERSITYDissecting Bacterial Cell Wall Synthesis Using In Vivo Single Molecule Tracking
GLICKFELD, LINDSEY LDUKE UNIVERSITYContext-Dependent Changes in Local and Long-Range Cortical Circuits
GOODWIN, ANDREW PUNIVERSITY OF COLORADORapid, Multiscale Sensing Using Acoustic Detection Mechanisms
HALLEM, ELISSA ANYONUNIVERSITY OF CALIFORNIA LOS ANGELESThe Neural Basis of Odor-Driven Behavior in Skin-Penetrating Parasitic Nematodes
HENDON, CHRISTINE PCOLUMBIA UNIV NEW YORK MORNINGSIDEHigh Resolution Imaging of the Myocardium
HUH, DONGEUNUNIVERSITY OF PENNSYLVANIAProbing the Physics of Chronic Lung Disease Using Microphysiological Biomimicry
INGOLIA, NICHOLAS TUNIVERSITY OF CALIFORNIA BERKELEYMolecular Basis and Cellular Roles of Translational Regulation
JANELSINS, MICHELLE CUNIVERSITY OF ROCHESTERClinical and Translational Approaches to Cognitive Impairments in Cancer
KADOCH, CIGALLDANA-FARBER CANCER INSTITUTEReversing Oncogenic BAF Complex Structure & Function: New Therapeutic Approaches
KOSURI, SRIRAMUNIVERSITY OF CALIFORNIA LOS ANGELESReverse Genomics of Regulatory Elements Governing Splicing
KREEGER, PAMELA KUNIVERSITY OF WISCONSIN-MADISONAnalysis of How Quantitative Cellular Network Variation Impacts Tumor Progression
LANDER, GABRIEL CEDRICTHE SCRIPPS RESEARCH INSTITUTEMolecular Basis of Axonal Transport Described by High-Resolution 3D Imaging
LIN, CHENXIANGYALE UNIVERSITYCell-Free Membrane Remodeling Guided by DNA Nano-Templates
LIPOVICH, LEONARDWAYNE STATE UNIVERSITYLife, Death, and Function: The Primate-Specific Long Non-Coding RNA Transcriptome
MARTIN, BRENT RANDALLUNIVERSITY OF MICHIGANMultiscale Chemical Approaches to Map Oxidative Stress
MCALPINE, MICHAELUNIVERSITY OF MINNESOTA3D Printed Nano-Bionic Organs
MURTHY, MALAPRINCETON UNIVERSITYHow Does the Brain Solve the Pattern Recognition Problem? 
NEUERT, GREGORVANDERBILT UNIVERSITDecoding the Noncoding Genome: lncRNA Dynamics and Function in Single Cells
ROSENBLUM, MICHAEL DAVIDUNIVERSITY OF CALIFORNIA SAN FRANCISCOFunctional Manipulation of Memory Regulatory T cells in Skin
ROUND, JUNE LOUISEUNIVERSITY OF UTAHDeveloping Therapies to Target the Microbiota
SCHOGGINS, JOHN WUT SOUTHWESTERN MEDICAL CENTERDiscovery of Antiviral Mechanisms in Bats
SFEIR, AGNELNEW YORK UNIVERSITY SCHOOL OF MEDICINETelomere-Independent Strategies to Protect Chromosome Ends
SIMON, MATTHEW DAVIDYALE UNIVERSITYIntegrating RNAs into Signaling Pathways by Engineering Covalent RNA Modification
STABENFELDT, SARAH EARIZONA STATE UNIVERSITY-TEMPE CAMPUSDetecting and Treating Traumatic Brain Injury Pathology Progression from the Inside-Out
TAGA, MICHIKO EUNIVERSITY OF CALIFORNIA BERKELEYTargeted Killing of Bacteria in Communities
TIAN, LINUNIVERSITY OF CALIFORNIA AT DAVISFluorescent Biosensors for Imaging Neurotransmitters: Observing Synapses in Action
WAN, LEO QRENSSELAER POLYTECHNIC INSTITUTECell Chirality Based In Vitro Models for Embryonic Development and Abnormalities
WESTREICH, DANIEL JUNIV OF NORTH CAROLINA CHAPEL HILLFrom Patients to Policy: Innovative Epidemiology for Implementation Science
XU, RONGCASE WESTERN RESERVE UNIVERSITYRapid Reverse Translational Drug Repositioning
YANG, LEIUNIVERSITY OF PITTSBURGHToward Regeneration of Whole Bioartificial Human Heart
YANG, LILIUNIVERSITY OF CALIFORNIA LOS ANGELESStem Cell-Engineered Invariant Natural Killer T Cells for Cancer Therapy
ZHANG, LIJIE GRACEGEORGE WASHINGTON UNIVERSITYA Novel 3D Bioprinted Smart Vascularized Nano Tissue
ZHAO, WEIANUNIVERSITY OF CALIFORNIA IRVINEMechano-Sensing Stem Cells to Study, Detect and Treat Cancer Metastases
ZONCU, ROBERTOUNIVERSITY OF CALIFORNIA BERKELEYEngineering Organelle Function to Rewire Cancer Cell Metabolism
ZONG, CHENGHANGBAYLOR COLLEGE OF MEDICINEDetecting the Onset of Genome Heterogeneity in Tumor at Single Cell Resolution

 

2013 NIH Director's New Innovator Award (DP2) (RFA-RM-12-016)

PI NameInstitution NameTitle
ADESNIK, HILLELUNIVERSITY OF CALIFORNIA BERKELEYNew Optical Strategies to Unlock the Neural Basis of Perception
AHERN, JENNIFERUNIVERSITY OF CALIFORNIA BERKELEYA Rigorous System to Determine the Health Impacts of Policies and Programs
ALDRIDGE, BREE BEARDSLEYTUFTS UNIVERSITY BOSTONQuantitative Design of Multi-Drug Regiments for Tuberculosis
ATON, SARA JUNIVERSITY OF MICHIGANLinking Network Activity and Intracellular Plasticity Mechanisms During Sleep-Dependent Memory Consolidation
BLISH, CATHERINE ASTANFORD UNIVERSITYHarnessing Natural Killer Cell Memory to Fight Viruses
CRAWFORD, JASON MICHAELYALE UNIVERSITYCryptic Gut Bacterial Metabolites that Regulate Colorectal Cancer Formation
DAR, ARVINMOUNT SINAI SCHOOL OF MEDICINETargeting Ras-Dependent Cancers with a Chemical Switch for an Inactive Kinase
DEO, RAHUL CHANDRAKANTUNIVERSITY OF CALIFORNIA-SAN FRANCISCOResolving Incomplete Penetrance in the Cardiomyopathies and Channelopathies
DIEHN, MAXIMILIANSTANFORD UNIVERSITYDeveloping a Genomic Approach for Cancer Screening
DVORIN, JEFFREY DCHILDREN'S HOSPITAL CORPORATIONEssential Gene Discovery in the Malaria Parasite Plasmodium falciparum
ESSER-KAHN, AARON PALMERUNIVERSITY OF CALIFORNIA IRVINEDirecting the Immune System via Polymeric Combinations of Molecular Signals
EVANS, SCOTT EUT MD ANDERSON CANCER CTRInducible Epithelial Antiviral Resistance to Prevent Asthma
FIEDLER, DOROTHEAPRINCETON UNIVERSITYUnderstanding Phosphate Metabolism in Cancer and Metastasis
FROST, ADAMUNIVERSITY OF UTAHToward Atomic Resolution of Membranes and Membrane-Associated Machines
GANDHI, SUNILUNIVERSITY OF CALIFORNIA IRVINERewiring Cortex Using Inhibitory Neuron Transplantation
GARTNER, ZEV JORDANUNIVERSITY OF CALIFORNIA-SAN FRANCISCOTotal Synthesis of the Human Mammary Gland
GRADINARU, VIVIANACALIFORNIA INSTITUTE OF TECHNOLOGYNeuromodulation and Neurodegeneration: The Missing Link and Mechanisms of Action
GREGG, ROBERT DUNIVERSITY OF TEXAS DALLASPhase-Based Control of Locomotion for High-Performance Prostheses and Orthoses
HANSEN, SCOTT B SCRIPPS FLORIDAMolecular Mechanism of Mechanosensation
LAMB, TRACEY JANEEMORY UNIVERSITYThe Development of Probiotic Yeast as an Inexpensive Vaccine Delivery Platform
LUCKS, JULIUS BEAUCORNELL UNIVERSITYA New High-Throughput Technology to Reveal the Dynamic Functional States of RNAs
MARR, LINSEYVIRGINIA POLYTECHNIC INST AND ST UNIVThe Role of Pathogen-Environment Interactions in the Pandemic Potential of Influenza
MERRIKH, HOURAUNIVERSITY OF WASHINGTONTargeted Gene Evolution via Replication-Transcription Conflicts
MORTAZAVI, SEYED ALIUNIVERSITY OF CALIFORNIA IRVINEComparative Analysis of the 4D Encoding of Regulatory Networks in Stem Cells
O'CONNELL, RYANUNIVERSITY OF UTAHUtilizing TALEN Technology to Regulate Human microRNAs
ONNELA, JUKKA-PEKKAHARVARD UNIVERSITY (SCH OF PUBLIC HLTH)Using Mobile Phones for Social and Behavioral Sensing of Mood Disorder Patients
PETERSEN, CHRISTIANNORTHWESTERN UNIVERSITYRegulatory Circuits Controlling Regenerative Growth
PEYTON, SHELLY RUNIVERSITY OF MASSACHUSETTS AMHERSTTissue-Specific Stem Cells and Breast Cancer Tissue Tropism
RUTA, VANESSAROCKEFELLER UNIVERSITYConnecting Neural Plasticity to Learning and Memory
SAHIN, OZGURCOLUMBIA UNIV NEW YORK MORNINGSIDENovel Sub-Cellular Chemical and Mechanical Nanoimaging
SANJABI, SHOMYSEHJ. DAVID GLADSTONE INSTITUTESCharacterizing HIV Latent Reservoir In Vivo
SATTELY, ELIZABETH SUSANSTANFORD UNIVERSITYLiberation of Plant Nutrients by the Gut Microbiota
SAVAGE, DAVID FRANKUNIVERSITY OF CALIFORNIA BERKELEYFluorescent Biosensors for Metabolite Imaging in Live Cells
SEANDEL, MARCOWEILL MEDICAL COLL OF CORNELL UNIVClonal Competition in Stem Cells as a Driver of Paternal Age Effect Diseases
SIVARAMAKRISHNAN, SIVARAJUNIVERSITY OF MICHIGANThe Kinase Toolbox: Mapping the Spatial and Temporal Regulation of Cell Signaling
TAYLOR, DEREK JAMESCASE WESTERN RESERVE UNIVERSITYInduction of Cancer Cell Death by Selective DNA Misincorporation
TISCHLER, ANNA DEGRAFFUNIVERSITY OF MINNESOTAHigh-Throughput Identification of Mycobacterium tuberculosis Persistence Mechanism
TYE, KAY MAXINEMASSACHUSETTS INSTITUTE OF TECHNOLOGYA Novel Strategy for Combating Obesity: Reprogramming Neural Circuits
WHITE, RICHARD MARKSLOAN-KETTERING INST CAN RESEvolutionary Dynamics of Melanoma Metastasis
WONG, WILSONBOSTON UNIVERSITY (CHARLES RIVER CAMPUS)Synthetically Reengineered T Cells as the Next Generation of Smart Cancer Therapy
ZHENG, YINGUNIVERSITY OF WASHINGTONA Microfluidic Bone Marrow Niche for the Study of Hematopoiesis

 

2012 NIH Director's New Innovator Award (DP2) (RFA-RM-11-005)

PI NameInstitution NameTitle
ALLEN, CHRISTOPHER DAVIDUNIVERSITY OF CALIFORNIA SAN FRANCISCOCellular Interactions in Asthma
AUGUSTE, DEBRAHARVARD UNIVERSITYPersonalized Therapeutics for Inhibiting Breast Cancer Metastasis
BALSKUS, EMILY PATRICIAHARVARD UNIVERSITYBiocompatible Chemistry for In Vivo Metabolite Modification
BIVONA, TREVER GUNIVERSITY OF CALIFORNIA SAN FRANCISCODiscovery of Rational Companion Therapeutic Targets to Optimize Cancer Treatment
BONKOWSKY, JOSH LEITCHUNIVERSITY OF UTAHTrans-Cellular Activation of Transcription to Analyze Dopaminergic Axon Reorganization
BORENSTEIN, ELHANANUNIVERSITY OF WASHINGTONA Computational Framework for Designing Microbiome Manipulation
BRANGWYNNE, CLIFFORD PPRINCETON UNIVERSITYCell Growth Control by Cell and Organelle Size-Dependent Ribosome Biogenesis
CAMP, AMY HITCHCOCKLEHIGH UNIVERSITYA Feeding Tube Model for Bacterial Cell-Cell Communication
CARETTE, JAN EDUARDSTANFORD UNIVERSITYGenetic Approaches to Discover Host Factors Critical to Dengue Virus Infection
CHEN, SHUIBINGWEILL MEDICAL COLLEGE OF CORNELL UNIVStudying the Progression and Regression of Beta Cell Dysfunction in Type 2 Diabetes Mellitus Using Humanized Mouse Models
CHI, PINGSLOAN-KETTERING INSTITUTE FOR CANCER RESAn Integrative Approach to Target Lineage-Specific Oncogenic Transcription Factor
CHURCHLAND, MARKCOLUMBIA UNIVERSITY HEALTH SCIENCESA Dynamical Systems Approach to Fundamental Questions in Neuroscience
CUI, BIANXIAOSTANFORD UNIVERSITYEngineering External Forces for Manipulating Cargo Transport in Live Neurons
DANTAS, GAUTAMWASHINGTON UNIVERSITYMetagenomic Engineering of Probiotic Bacteria to Improve Intestinal Colonization
DONG, P DUC SISANFORD-BURNHAM MEDICAL RESEARCH INSTITUnlocking Regenerative Potential Through In Vivo Genetic Reprogramming
FALK, EMILYUNIVERSITY OF PENNSYLVANIACan Neuroscience Dramatically Improve Our Ability to Design Health Communications
FEINBERG, ADAM WALTERCARNEGIE-MELLON UNIVERSITYHuman Myocardium Engineered Using Developmentally-Inspired Protein Scaffolds
GILL, HARVINDER SINGHTEXAS TECH UNIVERSITYPollen Grains as Trojan Horses for Oral Vaccination
GOODMAN, ANDREW LYALE UNIVERSITYDefining the Contribution of Interpersonal Microbial Variation to Drug Metabolism
GORE, JEFFMASSACHUSETTS INSTITUTE OF TECHNOLOGYEarly Warning Indicators of Tipping Points in Biological Systems
HAN, XUEBOSTON UNIVERSITYLight-Actuatable NanoRobots for Molecular Uncaging
HELLER, DANIEL ALANMEMORIAL SLOAN KETTERING CANCER CENTERTransient Metabolite Detection for Single-Cell Metabolomics and Diagnostics
HIGGINS, JOHN MATTHEWMASSACHUSETTS GENERAL HOSPITALSystems Biology of In Vivo Human Blood Cell Populations
JOHNSON, LAURA AUNIVERSITY OF PENNSYLVANIAGene-Engineered Adoptive T Cell Immunotherapy of GBM
KOHLI, RAHUL MANUUNIVERSITY OF PENNSYLVANIACombating Bacterial Drug Resistance by Targeting the Enzymes of Evolution
KRONAUER, DANIELROCKEFELLER UNIVERSITYStudying the Molecular Mechanisms of Social Life Using a Novel Ant Model System 
LILLEMEIER, BJOERN FSALK INSTITUTE FOR BIOLOGICAL STUDIESDecipher Membrane Patterns In Situ with Super-Resolution and Dynamic Microscopy
LIU, ALLEN PO-CHIHUNIVERSITY OF MICHIGAN AT ANN ARBORBuilding Artificial Platelets
LIU, WENDYUNIVERSITY OF CALIFORNIA IRVINEEngineering Biomaterials to Exert Molecular Control of Immune Cell Function
MAIMON, GABYROCKEFELLER UNIVERSITYLinking Genes to Higher Brain Function by Way of Cellular Electrophysiology
MARRAFFINI, LUCIANO AROCKEFELLER UNIVERSITYUsing CRISPR Immunity to Prevent the Spread of Virulence Traits Among Pathogens
MIN, WEICOLUMBIA UNIV NEW YORK MORNINGSIDELabel-Free Chemical Imaging for Biological Applications
MYONG, SUAUNIVERSITY OF ILLINOIS URBANA-CHAMPAIGNQuantitative Stepwise Analysis of RNA Interference
NIELL, CRISTOPHERUNIVERSITY OF OREGONConnecting Developmental Mechanisms to Visual Function and Perception
NIMMERJAHN, AXELSALK INSTITUTE FOR BIOLOGICAL STUDIESNovel Approaches to Study Microglia Physiology and Pathology in the Intact Brain
PERMAR, SALLIE RDUKE UNIVERSITYMaternal Immune Protection Against Congenital CMV Infection
PERTSINIDIS, ALEXANDROSSLOAN-KETTERING INSTITUTE FOR CANCER RESUnderstanding Gene Transcription from First-Principles: A Single-Molecule Study
PRLIC, MARTINFRED HUTCHINSON CANCER RESEARCH CENTERPaving the Way for a Novel Therapeutic Approach to Combat HIV
RODAL, AVITAL ADAHBRANDEIS UNIVERSITYActivity-Dependent Regulation of Membrane Traffic and Growth Signaling in Neurons
ROHATGI, RAJATSTANFORD UNIVERSITYReconstructing Primary Cilia
SCHAEFER, ANNEMOUNT SINAI SCHOOL OF MEDICINECognate Microglia-Neuron Interaction and Its Role in Inflammation
SHU, XIAOKUNUNIVERSITY OF CALIFORNIA SAN FRANCISCONew Principle-Based Technologies for Identifying Transient Protein Interactions
SOHAL, VIKAAS SINGHUNIVERSITY OF CALIFORNIA SAN FRANCISCOReverse Engineering the Prefrontal Microcircuit
STOLTZ, DAVID AUNIVERSITY OF IOWAAirway Goblet Cells: Friend or Foe?
SU, MINGNORTHEASTERN UNIVERSITYEnhanced Radiation Therapy with Nanoscale Frequency Modulators
URBAN, ALEXANDER ECKEHARTSTANFORD UNIVERSITYGenomic and Epigenomic Effects of Large CNV in Neurons from iPSC
WITTEN, ILANAPRINCETON UNIVERSITYTherapeutic Plasticity: A Novel Paradigm for Treating Addiction
WOODROW, KIM AUNIVERSITY OF WASHINGTONNanomaterials for Engineering Protection in the Genital Mucosa
YOO, ANDREWWASHINGTON UNIVERSITYMicroRNA and Neural Factor-Mediated Direct Reprogramming of Cell Fates
ZHENG, SIYANGPENNSYLVANIA STATE UNIVERSITY-UNIV PARKIntegration of Flexible Micro Spring Array and High Throughput Microfluidics for Obtaining Clinical Relevant Information from Circulating Tumor Cells
ZOVEIN, ANN CAPELAUNIVERSITY OF CALIFORNIA SAN FRANCISCOEngineering Human Endothelium for Hematopoietic Stem Cell Production

 

2011 NIH Director's New Innovator Award (DP2) (RFA-RM-10-009)

PI NameInstitution NameTitle
ALLER, STEPHEN GUNIVERSITY OF ALABAMA AT BIRMINGHAMStreamlined Structures of Human Integral Membrane Proteins at Atomic Resolution
BAKER, AARON BLAIRUNIVERSITY OF TEXAS AUSTINEngineering Effective Revascularization Strategies for Ischemia in Disease States
BARNA, MARIASTANFORD UNIVERSITYSpecialized Ribosomes in Control of Gene Expression and Embryonic Development
BASU, UTTIYACOLUMBIA UNIVERSITY HEALTH SCIENCESNon-Coding RNA Engineers Antibody Diversity
BUCHLER, NICOLAS EMILEDUKE UNIVERSITYRewiring the Yeast Brain: Redundancy and Interference in Genetic Networks
CAI, LONGCALIFORNIA INSTITUTE OF TECHNOLOGYSystems Biology in Single Cells by Super-Resolution Barcoding
CANMAN, JULIE CCOLUMBIA UNIVERSITY HEALTH SCIENCESIR-LAMP: Optigenetic Technology to Spatially Manipulate Protein Function In Vivo
CARLSON, ERIN ELIZABETHUNIVERSITY OF MINNESOTATargeted Natural Product Diversification to Identify Novel Antibacterial Agents
CHANG, EDWARDUNIVERSITY OF CALIFORNIA SAN DIEGOFunctional Architecture of Human Speech Motor Cortex
CHANG, JOHN TUNIVERSITY OF CALIFORNIA SAN DIEGOUnderstanding the Basis for Cellular Diversity During Adaptive Immunity
CHANG, MICHELLE CUNIVERSITY OF CALIFORNIA BERKELEYDiscovery and Mechanistic Study of Fluorine Biochemistry
CHENG, WEIUNIVERSITY OF MICHIGAN AT ANN ARBORSingle Cell with One Particle Entry (SCOPE) for Study of HIV Infection
CHRISTOFK, HEATHER RENEEUNIVERSITY OF CALIFORNIA LOS ANGELESRegulation of the Warburg Effect in Cancer
FRASER, HUNTER BSTANFORD UNIVERSITYSystematic Functional Annotation of Human Cis-Regulatory Genetic Variation
GERSBACH, CHARLES ADUKE UNIVERSITYEngineering Morphogenetic Factors for Enhanced Genetic Reprogramming
GEURTS, ARON MMEDICAL COLLEGE OF WISCONSINAdvanced Genetic Engineering Technology Development
GIANNESCHI, NATHAN CLAUDEUNIVERSITY OF CALIFORNIA SAN DIEGOProgramming Pharmacokinetics In Vivo via In Situ Switching of Nanoscale Particle Morphology
GOENTORO, LEACALIFORNIA INSTITUTE OF TECHNOLOGYRelative Perception in Wnt Signaling
HAMMOND, MING CHENUNIVERSITY OF CALIFORNIA BERKELEYA Chemical Biology Approach to Tagging RNAs in Live Cells
HAN, SONGIUNIVERSITY OF CALIFORNIA SANTA BARBARAProbing Early Protein Aggregation Mechanisms and Their Relationship to Disease Effects Through the Innovation of Highly Amplified and Time-Resolved Electron-Nuclear Spin Magnetic Resonance
HUANG, BOUNIVERSITY OF CALIFORNIA SAN FRANCISCOSolving Macromolecular Complex Architecture In Situ by Super-Resolution Microscopy
HUG, CHRISTOPHERCHILDREN'S HOSPITAL BOSTONMacrophage Integrated and Targeted Yeast Therapeutics
JIANG, HONGRUIUNIVERSITY OF WISCONSIN MADISONAccommodative Contact Lens for Presbyopic Correction
KALANTRY, SUNDEEPUNIVERSITY OF MICHIGAN AT ANN ARBORInitiation of Epigenetic Transcriptional Regulation
KASKO, ANDREA MARIEUNIVERSITY OF CALIFORNIA LOS ANGELESPhototunable Biomaterials to Engineer Complex 3D Cell Microenvironments
KING, MEGAN CYALE UNIVERSITYThe Role of Nuclear Architecture in Adaptation
KOSAK, STEVEN TODDNORTHWESTERN UNIVERSITYSelf-Organization of the Human Genome
LAMICHHANE, GYANUJOHNS HOPKINS UNIVERSITYNew Drug for Treatment of Chronic Bacterial Infection
LEE, SEOK-YONGDUKE UNIVERSITYPharmacology and Biophysics of the Voltage-Gated Sodium Channel Nav1.7: A Therapeutic Target for Pain
LEE, SHAUN WUNIVERSITY OF NOTRE DAMEDesign and Use of Novel Bacteriocins
LIEBERMAN AIDEN, EREZBROAD INSTITUTE, INC.Exploring How the Genome Folds Through Proximity Ligation and Sequencing
LU, TIMOTHYMASSACHUSETTS INSTITUTE OF TECHNOLOGYHigh-Throughput Nanoscale Approaches to Studying and Inhibiting Amyloid Toxicity
MAVERAKIS, EMANUAL MUNIVERSITY OF CALIFORNIA DAVISInvestigation and Development of New Therapeutic Avenues for Scleroderma
MITCHELL, DOUGLAS ALANUNIVERSITY OF ILLINOIS URBANA-CHAMPAIGNA Common Denominator of Pathogenesis; A Rare Opportunity for Novel Therapeutic Development
OTT, HARALD CMASSACHUSETTS GENERAL HOSPITALOrgan Engineering Based on Perfusion Decellularized Matrix
PADERA, TIMOTHY PMASSACHUSETTS GENERAL HOSPITALCharacterizing Lymphatic Micrometastases: Prognostic and Therapeutic Implications
PAEGEL, BRIAN MSCRIPPS FLORIDAEvolving and Engineering New Protease Tools for Mass Spectrometry Proteomics
PETRASCHECK, MICHAELSCRIPPS RESEARCH INSTITUTEModulation of Sensory Perception to Treat Age Related Disease
QUEITSCH, CHRISTINEUNIVERSITY OF WASHINGTONDoes Organismal Robustness Explain the Missing Heritability in Complex Diseases? 
RAJ, ARJUNUNIVERSITY OF PENNSYLVANIAComprehensive Spatial Picture of Transcription in the Nucleus
SCHLIEKER, CHRISTIAN DIRKYALE UNIVERSITYDeciphering Novel Protein Quality Control Pathways in the Nuclear Periphery
TOBIN, DAVID MDUKE UNIVERSITYModulating Eicosanoids to Treat Tuberculosis: Personalized, Host-Directed Therapy
WANG, CHIHHUNG JASONBOSTON MEDICAL CENTERHealthy Ideas Exchange
WEIBEL, DOUGLAS BENJAMINUNIVERSITY OF WISCONSIN MADISONRevisiting the Bacterial Cell Wall as a Target for New Antibiotics
WINGERT, REBECCA ANNUNIVERSITY OF NOTRE DAMEIdentification of Kidney Regeneration Mechanisms Using the Zebrafish
WU, JOY YMASSACHUSETTS GENERAL HOSPITALIn Vivo Reconstitution of the Hematopoietic Niche
XAVIER, JOAOSLOAN-KETTERING INSTITUTE FOR CANCER RESEngineering Microbial Social Interactions: Towards New Anti-Biofilm Therapies
ZHANG, QIVANDERBILT UNIVERSITYExplore Fundamental Aspects of Neurotransmission with Multifunctional Nanosensor
ZHONG, HAININGOREGON HEALTH AND SCIENCE UNIVERSITYExamining the Architecture of Synapses in Brain Tissue at Nanometer Resolution

 

2010 NIH Director's New Innovator Award (DP2) (RFA-RM-09-011)

PI NameInstitution NameTitle
AGAR, NATHALIE Y RBRIGHAM AND WOMEN'S HOSPITALReal-Time Stereotactic Mass Spectrometry Tissue Analysis for Intraoperative Neuro
AGARWAL, RITESHUNIVERSITY OF PENNSYLVANIAOptoelectronic Nanowire Probes for Investigation of Intra-Cellular Processes
AMARO, ROMMIE EUNIVERSITY OF CALIFORNIA-IRVINEA Structural Systems Biology Approach to Drug Discovery
ARAVIN, ALEXEI ACALIFORNIA INSTITUTE OF TECHNOLOGYTaming of Small RNA-based Epigenetic Mechanisms
ARMANI, ANDREA MARTINUNIVERSITY OF SOUTHERN CALIFORNIAUltrasensitive Nanolasers for Epigenetics Investigations
BAUTISTA, DIANA MICHELEUNIVERSITY OF CALIFORNIA BERKELEYNew Approaches to Identify Molecular Mechanisms of Touch and Pain in Mammals
CEGELSKI, LYNETTE SSTANFORD UNIVERSITYStructure, Function, and Disruption of Microbial Amyloid Assembly and Biofilm Formation
CHENG, JIANJUNUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGNDeveloping Clinically Applicable, Cancer-Targeting Polymeric Nanoconjugates
CHI, NEIL CUNIVERSITY OF CALIFORNIA, SAN DIEGODirected Cardiac Cellular Programming: A New Paradigm for Cardiac Regeneration
COHEN, ADAM EZRAHARVARD UNIVERSITYOptical Sensing of Voltage, pH, and Small Molecules Using Microbial Rhodopsins
DAI, CHENGKAIJACKSON LABORATORYRole of a Novel Stress Response Mechanism-Genetic Buffering-in Tumor Evolution
DATTA, SANDEEP RHARVARD MEDICAL SCHOOLRevealing Fear: New Methods to Study Neural Circuits, Behavior and Disease
DI CARLO, DINOUNIVERSITY OF CALIFORNIA LOS ANGELESEngineering the Intracellular Micro- and Nanoenvironment
DUNN, ALEXANDER RSTANFORD UNIVERSITYUncovering New Roles for Mechanical Force in Tissue Development and Remodeling
EVANS, CONOR LEEMASSACHUSETTS GENERAL HOSPITALImaging and Overcoming Hypoxia-Induced Resistance in Metastatic Ovarian Cancer
FELDMAN, BRIAN JSTANFORD UNIVERSITYUsing Components of the Circadian Clock to Regulate Stem Cell Fate Decisions
FELIPPE, MARIA JULIA BEVILAQUACORNELL UNIVERSITYEpigenetics: A Novel Approach in Primary Immunodeficiencies
FISCHBACH, MICHAEL ANDREWUNIVERSITY OF CALIFORNIA, SAN FRANCISCOIdentifying and Characterizing Small Molecules from the Human Microbiome
GARCIA, BENJAMIN APRINCETON UNIVERSITYNovel Methodology for Quantitative High-Throughput Cancer Epigenetics
GUERRERO, THOMAS MUNIVERSITY OF TX MD ANDERSON CAN CTRSpatially Accurate Deformable Image Registration for Thoracic CT Application
GUZMAN, MONICA LWEILL MEDICAL COLL OF CORNELL UNIVSelection of Novel Therapies to Ablate Chemoresistant Myeloid Leukemia Stem Cell
HERR, AMY ELIZABETHUNIVERSITY OF CALIFORNIA BERKELEYTowards High Throughput Proteomics: A Micro/nanofluidic Framework for Blotless Western Technology
HOTOPP, JULIEUNIVERSITY OF MARYLAND BALTIMOREImpact of Bacterial-Animal Lateral Gene Transfer on Human Health
HUANG, TONY JUNPENNSYLVANIA STATE UNIVERSITY-UNIV PARKOn-Chip Optofluidic Laser Scanning Confocal Microscope for Early Cancer Detection
HUANG, YUUNIVERSITY OF CALIFORNIA LOS ANGELESGraphene Nanostructures as a New Platform for Ultrasensitive Multiplexed Biologic
KHINE, MICHELLEUNIVERSITY OF CALIFORNIA-IRVINEShrink Induced Manufacturing Platform for Low-Cost Diagnostics (SIMPL-CD)
KLEIN, OPHIR DUNIVERSITY OF CALIFORNIA, SAN FRANCISCOAn Evolutionary-Developmental Approach to Stem Cells Using Teeth as a Model
KRITZER, JOSHUA ATUFTS UNIVERSITY MEDFORDDrugging the Undruggable: Targeting Transcription Factors with Small Cyclic Pept
LAIRD, DIANA JUNIVERSITY OF CALIFORNIA, SAN FRANCISCOCell Competition in the Developing Mouse Germline
LAVIK, ERINCASE WESTERN RESERVE UNIVERSITYClinically Translatable Nanotechnology: Hemostasis and Neuroprotection
LEE, JIN HYUNGUNIVERSITY OF CALIFORNIA LOS ANGELESIn Vivo Control and Functional Visualization of Stem Cell-Driven CNS Regeneration
LEVY, HARAMEDICAL COLLEGE OF WISCONSINIntegration of Genomics with Genetics - Molecular Phenotypes for CF Lung Disease
LEY, RUTH EMILYCORNELL UNIVERSITYDevelopment of Immunization Strategies to Reshape Pathogenic Microbiomes
LUO, MINKUISLOAN-KETTERING INST CAN RESEARCHEnzyme-Engineering Approaches to Dissect Protein Methylation Profiles
MAJOR, MICHAEL BENJAMINUNIV OF NORTH CAROLINA CHAPEL HILLExploitation of Near-Haploid Human Cells for Functional Gene Discovery
MARCH, JOHN CCORNELL UNIVERSITYEngineering Commensal Bacteria as Therapeutic Signal Mediators
NELSON, TIMOTHY JAMESMAYO CLINIC ROCHESTERDysfunctional Regeneration in Cardiomyopathy: iPS-Based Diagnosis and Therapy
NICULESCU, ALEXANDER BINDIANA UNIV-PURDUE UNIV AT INDIANAPOLISDeveloping Blood Tests for Mood Disorders
NILES, JACQUIN CMASSACHUSETTS INSTITUTE OF TECHNOLOGYEngineered Regulated RNA Localization and Transport in Biological Systems
NOLAN, ELIZABETH MMASSACHUSETTS INSTITUTE OF TECHNOLOGYAntibacterial Peptides and Zinc in Innate Immunity and Mammalian Physiology
PLATT, MANU OGEORGIA INSTITUTE OF TECHNOLOGYMultiscale, Mechanistic, and Predictive Models of Stroke in Sickle Cell Disease
SEALE, PATRICKUNIVERSITY OF PENNSYLVANIAMolecular Regulation of Brown Adipose Cell Fate in Somitic Stem Cells
SITHARAMAN, BALAJISTATE UNIVERSITY NEW YORK STONY BROOKNanotechnology-Based Theranostic Technology for Bone Tissue Engineering
THEOGARAJAN, LUKE SATISH KUMARUNIVERSITY OF CALIFORNIA SANTA BARBARABio-Ionic Neural Interfaces
TUCKER, BUDD AUNIVERSITY OF IOWADevelopment of a Cell Replacement Therapy to Treat Retinal Degenerative Blindness
WADE, JOSEPH THOMASWADSWORTH CENTERPervasive Transcription in Bacterial Genomes
WEISS, LAUREN ANNEUNIVERSITY OF CALIFORNIA, SAN FRANCISCODissecting Epistasis and Pleiotropy in Autism Towards Personalized Medicine
WONG, PAK KINUNIVERSITY OF ARIZONAMechanoregulation of Tissue Morphogenesis
YANG, CHANGHUEICALIFORNIA INSTITUTE OF TECHNOLOGYApplications of Time-Reverse Tissue Turbidity Suppression to Improve Biophotonics
YIN, PENGHARVARD MEDICAL SCHOOLEngineering Bioimaging Probes Based on Triggered Molecular Geometry
ZHAO, XILINUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOLAnaerobic Shock as a Novel Treatment for Tuberculosis
ZHONG, SHENGUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGNEvolutionary Models for Gene Regulatory Networks

 

2009 NIH Director's New Innovator Award (DP2) (RFA-RM-09-003)

PI NameInstitution NameTitle
ALBERS, MARK WMASSACHUSETTS GENERAL HOSPITALThe Olfactory Neural Circuit as a Systems Level Model of Neurodegenerative Disease
ALMUTAIRI, ADAHUNIVERSITY OF CALIFORNIA SAN DIEGOChemically Amplified Response Strategies for Medical Sciences; Concepts Borrowed from the Electronics Industry
ASHLEY, EUAN ASTANFORD UNIVERSITYNanoscale Approaches to Allelic Silencing in Myocardial Disease States
BAGNAT, MICHELDUKE UNIVERSITYDiscovering New Regulators of CFTR and Fluid Secretion in Zebrafish
BALAZSI, GABORUNIVERSITY OF TEXAS MD ANDERSON CAN CTRConnecting the Selection of Noisy Gene Expression Deviants to Genetic Evolution
BANERJEE, IPSITAUNIVERSITY OF PITTSBURGH AT PITTSBURGHDefining Mechanisms Controlling Stem Cell Fate during DifferentiationARRA Logo
BROWN, EDWARD BERNARDUNIVERSITY OF ROCHESTERExploiting Collagen Organization to Predict and Prevent Tumor Metastasis
CAMARGO, FERNANDOCHILDREN'S HOSPITAL BOSTONAnalysis of Stem Cell Dynamics and Differentiation by Cellular BarcodingARRA Logo
CHRONIS, NIKOLAOSUNIVERSITY OF MICHIGAN AT ANN ARBORA Biochip for Point-of-Care HIV/AIDS Diagnosis in the Developing WorldARRA Logo
COHEN THEODORE HBRIGHAM AND WOMEN'S HOSPITALPrevalence, Risk Factors and Consequences of Complex M. tuberculosis Infections
DERIEMER, KATHRYNUNIVERSITY OF CALIFORNIA DAVISTransmission and Virulence of Mycobacterium tuberculosis
DIAZ, ELVA DUNIVERSITY OF CALIFORNIA DAVISGeneration of Tumor Stem Cell Lines for Directed Therapeutics of Brain Cancer
ENGLER, ADAM JEFFREYUNIVERSITY OF CALIFORNIA SAN DIEGO"Smart" Materials to Engineer a More Complete Stem Cell Niche
GRISHOK, ALLACOLUMBIA UNIVERSITY HEALTH SCIENCESInvestigating the Potential of Endogenous RNAi in Mediating Adaptation to Environment
HALL, IRA MUNIVERSITY OF VIRGINIA CHARLOTTESVILLEExtent, Origin, and Control of Structural Variation in Mammalian Genomes
HEILSHORN, SARAH CSTANFORD UNIVERSITYEngineering 3D In Vitro Niches to Reveal Fundamentals of Cellular Biomechanics
HUANG KERWYN CASEYSTANFORD UNIVERSITYEngineering of Cell Shape and Intracellular Organization
JAIN, SANJAYJOHNS HOPKINS UNIVERSITYNovel Imaging Biomarkers to Address Fundamental Controversies in TB Pathogenesis
JANES, KEVIN AUNIVERSITY OF VIRGINIA CHARLOTTESVILLEStochastic Control of Abnormal Morphogenesis Induced by the ErbB2 Oncoprotein
KEMP, MELISSA LAMBETHGEORGIA INSTITUTE OF TECHNOLOGYRedox Regulation of Cellular Information Processing
KREIMAN, GABRIELCHILDREN'S HOSPITAL BOSTONTowards the Neuronal Correlates of Visual Awareness
KRISTICH, CHRISTOPHER JMEDICAL COLLEGE OF WISCONSINGenetic Approaches to Protein-Protein Interactions Mediating Antibiotic Resistance
KURDISTANI, SIAVASHUNIVERSITY OF CALIFORNIA LOS ANGELESA Blueprint for Oncogenic Epigenetic Reprogramming
KWATE, NAA OYO ACOLUMBIA UNIVERSITY HEALTH SCIENCESImmunologic Effects and a Structural "Countermarketing" Intervention: Racism, the HPA Axis, and African American Health
LEE, KIBUMRUTGERS THE ST UNIV OF NJ NEW BRUNSWICKCombinatorial Approaches for Studying Multiple Cues Regulating Human Pluripotent Stem Cell (hPSC) Fate
LIM, DANIEL AUNIVERSITY OF CALIFORNIA SAN FRANCISCOChromatin-Based Cellular Memory in Neural Stem Cells
LOMVARDAS, STAVROSUNIVERSITY OF CALIFORNIA SAN FRANCISCOCharacterization of the Role of CpA Methylation in Neuronal Plasticity
MACHADO, ANDRE GUELMANCLEVELAND CLINIC LERNER COL/MED-CWRUDeep Brain Stimulation of the Ventral Anterior Limb of the Internal Capsule for Modulation of the Affective Sphere of Chronic Neuropathic Pain
MASOPUST, DAVIDUNIVERSITY OF MINNESOTA TWIN CITIESMaximizing CD8 T Cells for Protection
MORA, JORGE RODRIGOMASSACHUSETTS GENERAL HOSPITALReassessing the Physiological Role of Gut-Specific Lymphocyte Homing: Implication
MUOTRI, ALYSSON RUNIVERSITY OF CALIFORNIA SAN DIEGOModeling Autism with Human Pluripotent Cells
NAGRATH, SUNITHAMASSACHUSETTS GENERAL HOSPITALEngineering Sensitive Microfluidic Multiplex Technology for Isolating Circulating
NANDA, VIKASUNIV OF MED/DENT NJ-R W JOHNSON MED SCHComputational Design of a Synthetic Extracellular Matrix
ORDWAY, DIANE JOYCECOLORADO STATE UNIVERSITY-FORT COLLINSImmune Modulation by Highly Virulent Clinical Isolates of M.TuberculosisARRA Logo
OZCAN, AYDOGANUNIVERSITY OF CALIFORNIA LOS ANGELESTowards Mega-Throughput, Label-Free Genomics and Proteomics: Revolutionizing Micro-Arrays
PAYNE, CHRISTINE KGEORGIA INSTITUTE OF TECHNOLOGYIntracellular Delivery and Targeting of Nanoparticles
PENN, ANNA ASTANFORD UNIVERSITYFetal Brain Damage: A Placental Disorder
PURDON, PATRICK LMASSACHUSETTS GENERAL HOSPITALA Neural Systems Approach to Monitoring and Drug-Delivery for General Anesthesia
QIAN, SHU-BINGCORNELL UNIVERSITY ITHACAEngineering Ubiquitin Ligases to Investigate Protein Aggregation and Neurodegeneration
QIAN, WEI-JUNBATTELLE PACIFIC NORTHWEST LABORATORIESA Universal Multiplex Assay System for High-Throughput Clinical Applications
REIJMERS, LEONTUFTS UNIVERSITY BOSTONMolecular Analysis of Functional Neural Circuits
REINEKE, THERESA MVIRGINIA POLYTECHNIC INST AND ST UNIVIlluminating the Mechanistic Pathways of Polymer-Mediated Nucleic Acid Delivery
RINN, JOHN LOUISBETH ISRAEL DEACONESS MEDICAL CENTERRNA and Chromatin Formation: From Discovery to Mechanism
SABETI, PARDIS CHRISTINEHARVARD UNIVERSITYHost and Pathogen Evolution in Lassa Fever
SAINT-GENIEZ, MAGALISCHEPENS EYE RESEARCH INSTITUTEBioengineering of Bruch's Membrane for the Treatment of Age-Related Macular Degeneration
SHOU, WENYINGFRED HUTCHINSON CANCER RESEARCH CENTERCellular Cooperation and Cheating: An Experimental and Mathematical Analysis
SONNENBURG, JUSTINSTANFORD UNIVERSITYDiscovery of Gut Microbiota-Targeted Small Molecules: New Tools and TherapeuticsARRA Logo
TAVAZOIE, SOHAIL FROCKEFELLER UNIVERSITYThe Discovery of microRNAs That Predict Chemotherapeutic Responsiveness of CancerARRA Logo
TIMLIN, JERILYNSANDIA CORP-SANDIA NATIONAL LABORATORIESMultiplexed Measurements of Protein Dynamics and Interactions at Extreme Resolution
TSO, CHO-LEAUNIVERSITY OF CALIFORNIA LOS ANGELESCellular Quiescence and Brain Tumor Stem Cells
ULLIAN, ERIK MUNIVERSITY OF CALIFORNIA SAN FRANCISCOThe Role of Astrocytes in Plasticity and Disease
VEZYS, VAIVA DUNIVERSITY OF MINNESOTA TWIN CITIESUnderstanding the Persistence of Immune-Mediated Chronic Diseases
WEINBERGER, LEOR SUNIVERSITY OF CALIFORNIA SAN DIEGODeveloping Transmissible Antivirals by Exploiting Gene-Expression CircuitryARRA Logo
ZHANG, CHUN-LIUNIVERSITY OF TEXAS SW MED CTR/DALLASNeurogenesis De Novo in the Adult Central Nervous System

 

2008 NIH Director's New Innovator Award (DP2) (RFA-RM-08-014)

PI NameInstitution NameTitle
BRYANT, ZEVSTANFORD UNIVERSITYEngineering Molecular Motors
BUCKANOVICH, RONALD JTHE REGENTS OF THE UNIVERSITY OF MICHIGANUsing Embryonic Stem Cells to Re-Create a Human Tumor Microenvironment to Develop Ovarian Cancer Therapeutic and Diagnostic Tools
CARDOZO, TIMOTHY JNEW YORK UNIVERSITY SCHOOL OF MEDICINEChemical Biology Design for Malaria
CHRISTMAN, KAREN LUNIVERSITY OF CALIFORNIA, SAN DIEGOEngineering a Dynamic Extracellular Matrix Microenvironment
COBB, BRIAN ACASE WESTERN RESERVE UNIVERSITYT Cell Dependent Immune Responses to Carbohydrate Antigens
COHN, RONALD DJOHNS HOPKINS UNIVERSITYMaintenance of Skeletal Muscle Mass: Lessons Learned from Hibernation
DUAN, XIANGFENGUNIVERSITY OF CALIFORNIA, LOS ANGELESIntegrated Free-Standing Nanoprobes for Neuroscience and Beyond
FIELD, SETH JUNIVERSITY OF CALIFORNIA, SAN DIEGOPhosphoinositides Provide Unique Insights into Cell Biology and Pathophysiology
GITAI, ZEMERPRINCETON UNIVERSITYDiscovering Antibiotic Drugs & Targets via High-Throughput Bacterial Cell Biology
GITLER, AARON DUNIVERSITY OF PENNSYLVANIA SCHOOL OF MEDICINEUsing Yeast Cells to Define Mechanisms of Human Neurodegenerative Diseases
GRACIAS, DAVID HJOHNS HOPKINS UNIVERSITYMinimally Invasive Micro-Nanoscale Tools and Devices for Medicine
HAYNES, CHRISTY LUNIVERSITY OF MINNESOTAImmune System-on-a-Chip for Quantitative Analysis of Cell Interactions during Allergy Response
KESLER, SHELLI RSTANFORD UNIVERSITY SCHOOL OF MEDICINEAssessment and Treatment of Cognitive Deficits in Breast Cancer
KIRICHOK, YURIYUNIVERSTITY OF CALIFORNIA, SAN FRANCISCOMolecular Biophysics of Mitochondrial Membranes: Defining Future Therapeutic Targets
KUMAR, SANJAYUNIVERSITY OF CALIFORNIA, BERKELEYCellular Mechanobiology: Biophysics and Therapeutics
KUO, CHAY TDUKE UNIVERSITY MEDICAL CENTERDiscovering Pathways Regulating Neurogenesis and Brain Remodeling after Injury
MAHAL, LARA KUNIVERSITY OF TEXAS AT AUSTINAn Integrated Systems Approach to Deconstructing Glycosylation
MURPHY, COLEEN TARAPRINCETON UNIVERSITY LEWIS-SIGLER INSTITUTESlowing the Ticking Clock: C. elegans Screens for Reproductive Aging Regulators
NOMA, KENICHIWISTAR INSTITUTEA New Methodology to Decipher Three-Dimensional Genome Structure
OHI, MELANIE DIANEVANDERBILT UNIVERSITY MEDICAL CENTERMultifaceted Approaches for Studying the Structure and Function of Spliceosomes
PFENNIG, KARIN SUNIVERSITY OF NORTH CAROLINA, CHAPEL HILLThe Origins and Maintenance of Context-Dependent Behavior
RAMALHO-SANTOS, MIGUELUNIVERSTITY OF CALIFORNIA, SAN FRANCISCORole of Pluripotency in Development of the Germline
RECK-PETERSON, SAMARA LHARVARD MEDICAL SCHOOLCellular Control of Microtubule-Based Transport: Unraveling Its Molecular Mechanism
SHAPIRO, ERIKYALE UNIVERSITY SCHOOL OF MEDICINESingle Cell MRI of Directed Cell Migration to Stroke
SHIH, WILLIAM MDANA-FARBER CANCER INSTITUTENMR Structure Determination of Membrane Proteins Enabled by DNA Nanotubes
WAGERS, AMY JOJOSLIN DIABETES CENTERAging and Rejuvenation of the Hematopoietic Stem Cell Niche
WANG, JUE DBAYLOR COLLEGE OF MEDICINEThe Molecular Interface of Replication Elongation and the Cellular Environment
WANG, LEISALK INSTITUTE OF BIOLOGICAL STUDIESGenetically Encoding Novel Amino Acids to Investigate Wnt Signaling in C. elegans
WU, JOSEPH CSTANFORD UNIVERSITY SCHOOL OF MEDICINEInducing Pluripotency with miRNAs: New Paradigm Shif in Cell Reprogramming
WU, SEAN MMASSACHUSETTS GENERAL HOSPITALGeneration of Functional Organs via Developmental Chimerism
ZEITLINGER, JULIASTOWERS INSTITUTE FOR MEDICAL RESEARCHInvestigating Developmental Potential Based on Genome-Wide Chromatin Status

 

2007 NIH Director's New Innovator Award (DP2) (RFA-RM-07-009)

PI NameInstitution NameTitle
AAGAARD-TILLERY, KJERSTIBAYLOR COLLEGE OF MEDICINECharacterization of the Fetal Primate Epigenome and Metabolome under In Utero Conditions of Maternal Obesity
BAILEY, RYANUNIVERSITY OF ILLINOIS URBANA-CHAMPAIGNPersonalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
BOYDEN, EDWARDMASSACHUSETTS INSTITUTE OF TECHNOLOGYNovel Tools and Principles for Precisely Controlling Brain Activity
CHAMPAGNE, FRANCESCOLUMBIA UNIV NEW YORK MORNINGSIDEEpigenetic Mechanisms Mediating the Inheritance of Reproductive Behavior
DAVIES, SEANVANDERBILT UNIVERSITYTransformed Probiotic Bacteria for Treatment of Chronic Diseases
FERNANDEZ-FUNEZ, PEDROUNIVERSITY OF TEXAS MEDICAL BR GALVESTONMechanisms of Prion Misfolding
FORTUNE, SARAHHARVARD UNIVERSITY (SCH OF PUBLIC HLTH)Variation in M. tuberculosis in Response to Host Selection
GARRAWAY, LEVIDANA-FARBER CANCER INSTITUTEDefining Melanoma Therapeutic Avenues by Integrative Functional Genomics
GUMBO, TAWANDAUNIVERSITY OF TEXAS SW MED CTR/DALLASEfflux Pump Inhibitors to Reduce Duration of Antituberculosis Therapy
HACOHEN, NIRMASSACHUSETTS GENERAL HOSPITALRevealing Pathogen-Sensing Pathways Using RNAi Libraries
HELDWEIN, EKATERINATUFTS UNIVERSITY BOSTONStructural and Mechanistic Studies of Herpesvirus Entry into Host Cells
HOCHEDLINGER, KONRADMASSACHUSETTS GENERAL HOSPITALReprogramming of Somatic Cells by Defined Factors
JACOBSON, KRISTENUNIVERSITY OF CHICAGOFrom Neighborhoods to Neurons and Beyond
JANKOWSKY, JOANNACALIFORNIA INSTITUTE OF TECHNOLOGYSelective Neuronal Silencing to Study Cognitive Decline in Alzheimer's Disease
JASANOFF, ALANMASSACHUSETTS INSTITUTE OF TECHNOLOGYGenetically-Controlled MRI Contrast Agents for Functional Brain Imaging
JOHNSON, MARKBRIGHAM AND WOMEN'S HOSPITALMicroRNA Biogenesis and the Cancer Proteome
LLINAS, MANUELPRINCETON UNIVERSITYNovel Antimalarial Strategies Using Metabolomic Network Discovery
PAPA, FEROZUNIVERSITY OF CALIFORNIA SAN FRANCISCONew Tools to Measure and Correct Endoplasmic Reticulum Stress in Single Living Cells
PE'ER, DANACOLUMBIA UNIV NEW YORK MORNINGSIDEGenetic Variation and Regulatory Networks: Mechanisms and Complexit
PLATH, KATHRINUNIVERSITY OF CALIFORNIA LOS ANGELESChromatin and Epigenetic Inheritance
RAPE, MICHAELUNIVERSITY OF CALIFORNIA BERKELEYUbiquitin-Dependent Mechanisms of Tissue-Specific Cell Cycle Control
ROSENBLATT, JODYUNIVERSITY OF UTAHIdentification of Signals that Extrude an Apoptotic Cell from an Epithelium
SAGHATELIAN, ALANHARVARD UNIVERSITYDiscovery Metabolite Profiling of the Prolyl Peptidases
SHORTER, JAMESUNIVERSITY OF PENNSYLVANIAAmyloid Elimination by Hsp104 and Substrate-Optimized Variants
SIPKINS, DOROTHYUNIVERSITY OF CHICAGOStem Cell, Tumor and Bone Marrow Microenvironment Cross-Talk In Vivo
SPIEGEL, DAVIDYALE UNIVERSITYSmall-Molecule Antibody Recruiting Therapeutics for Treating Human Disease
SZIGETHY, EVAUNIVERSITY OF PITTSBURGH AT PITTSBURGHUnderstanding and Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
TOOMRE, DEREKYALE UNIVERSITYNovel TIRF Microscopy for Analyzing Trafficking and Signaling at the Cell Cortex
YANG, JINGUNIVERSITY OF CALIFORNIA SAN DIEGOEpithelial-Mesenchymal Transition in Tumor Metastasis
YANIK, MEHMETMASSACHUSETTS INSTITUTE OF TECHNOLOGYDevelopment of On-Chip Ultra High-Throughput Whole-Animal Assay Technologies

This page last reviewed on February 15, 2024