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Program Snapshot

NIH Collaboratory Graphic IdentityThe goal of the NIH Health Care Systems (HCS) Research Collaboratory program is to engage health care delivery organizations like clinics or hospitals as research partners in the conduct of pragmatic clinical trials. Pragmatic clinical trials take place at the site of care and are designed to provide real world evidence on the benefits and risks of treatment options for health care providers and patients. The NIH Collaboratory generates and widely disseminates best practices for conducting pragmatic clinical trials through a number of outreach activities, including an online living textbook (link is external) and weekly Grand Rounds (link is external) webinars.

The HCS Research Collaboratory supports a series of pragmatic clinical trials in medical centers across the country and addresses a range of pressing public health concerns including cancer screening, pain management, kidney dialysis, hospital-acquired infections, medication adherence, suicide prevention, and advanced care planning. For more information about these trials and their outcomes please see the public health relevance page and program highlights.

To provide critical infrastructure that addresses the unique challenges of performing clinical trials in real world settings and to disseminate lessons learned, the program supports a Collaboratory Coordinating Center, the NIH Collaboratory (link is external). The NIH Collaboratory aids the design and rapid execution of pragmatic clinical trials, and develops and disseminates standard methods and best practices for working with health care delivery organizations as research partners through a living textbook (link is external).

Living Textbook

Visit the NIH Collaboratory website (link is external)for detailed information on:

NIH Collaboratory Website

Colored squares from the graphic Identity of the HCS CollaboratoryVisit the website maintained by the NIH Collaboratory Coordinating Center for in-depth program information and access to program resources. 

New Pragmatic Clinical Trials Funding Opportunity

New NIH Funding Opportunity Announcement (RFA-AT-22-001) for NIH Health Care Systems Research Collaboratory - Pragmatic and Implementation Trials of Embedded Interventions (UG3/UH3 Clinical Trials Optional) to solicit phased cooperative research applications to conduct efficient large-scale pragmatic or implementation trials embedded within health care systems. Applications are due December 15, 2021 and June 17, 2022.

Read about it in this NCCIH blog post.

Please note that this funding opportunity is not provided by the NIH Common Fund.

This page last reviewed on November 8, 2023