Protein Capture Reagents Program graphic identity

Program Snapshot

The goal of the Common Fund’s Protein Capture Reagents program is to develop a community resource of renewable, high-quality protein capture reagents, such as antibodies, with a focus on the creation of transcription factor reagents and testing next generation capture technologies. The program has developed new resources and tools to understand the critical role the multitude of cellular proteins play in development, health, and disease. These resources will support a wide-range of research and clinical applications by enabling the isolation and tracking of proteins of interest.

The program generated an array of monoclonal antibodies to transcription factor targets in addition to a host of recombinant antibodies. The Common Fund has provided funding to experts in the field of transcription factors to validate the usefulness of these antibodies. Using a variety of different methods, ranging from chromatin immunoprecipitation (ChIP) to microscopy studies, approximately 40 antibodies have already been identified as highly effective tools for biological studies. As more validation studies are completed, it is anticipated this number will increase. These antibodies are publicly available for purchase and can be located through the PCRP Data Portal. A 2016 commentary paper published in Nature Methods outlines the accomplishments of the program.

This page last reviewed on June 21, 2019