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2023 NIH Director’s Transformative Research Awards (R01)

RFA-RM-22-020

*Diversity Statement

PI Name Institution Name Title

CARVUNIS, ANNE-RUXANDRA (contact)

ATIANAND, MANINJAY K

JOGLEKAR, ALOK

SUBRAMANIAM, ARVIND

UNIVERSITY OF PITTSBURGH AT PITTSBURGH Unraveling microprotein biology with an evolutionary-immunological framework
KODADEK, THOMAS J UNIVERSITY OF FLORIDA Development of Ubiquitin-Independent Degraders
RINBERG, DMITRY  NEW YORK UNIVERSITY SCHOOL OF MEDICINE Odorprint Based Disease Diagnostics
ROUKES, MICHAEL L CALIFORNIA INSTITUTE OF TECHNOLOGY Next-generation spatial -omics: High-throughput, single-molecule proteomic imaging with subcellular resolution

SHIN, LISA MARIE (contact)

ALLEN, AERIELLE

SOMMERS, SAMUEL

TUFTS UNIVERSITY MEDFORD Effects of Racism on Brain and Physiological Pathways to Health Disparities
TYNES, BRENDESHA MARIE UNIVERSITY OF SOUTHERN CALIFORNIA Using Immersive Virtual Reality and Media Literacy to Enhance Adolescents' Coping Skills in the Face of Traumatic Online Experiences
2022 NIH Director's Transformative Research Award (R01)

RFA-RM-21-017

*Diversity Statement

PI Name Institution Name Title
ANDERSEN, JULIE KAY

 

BUCK INSTITUTE FOR RESEARCH ON AGING

 

A Smart Cell Drug (SmaCD) Delivery Platform for Mobile, Targetable, and Self-Regulated Combination Therapy: A Model Project to Rescue Antibodies from Alzheimers Disease (AD) Clinical Trial Failures

 

ANTON, EVA S (contact)

LICHTMAN, JEFF W

YASUDA, RYOHEI

UNIV OF NORTH CAROLINA CHAPEL HILL

 

Primary Cilia: A Novel Signaling Gateway to Neural Circuit Modulation

 

BEAUCHAINE, THEODORE PATRICK (contact); SHEFTALL, ARIELLE HOPE; VALENTINO, KRISTIN

 

UNIVERSITY OF NOTRE DAME

 

Leveraging Noninvasive Transcutaneous Vagus Nerve Stimulation and Smartphone Technology to Reduce Suicidal Behaviors and Suicide Among Highly Vulnerable Adolescents

 

BISHEHSARI, FARAZ

 

RUSH UNIVERSITY MEDICAL CENTER

 

Development of a Precision Medicine Platform for Circadian Based Therapeutics in Pancreatic Cancer

 

BRADY, DONITA C (contact); BURSLEM, GEORGE; BUSINO, LUCA; GADE, TERENCE P; WITZE, ERIC S

 

UNIVERSITY OF PENNSYLVANIA

 

Unlocking the Chemical Space of Cancer-Associated Perturbations

 

FISCHBACH, MICHAEL ANDREW

 

STANFORD UNIVERSITY

 

Building the Foundations of Commensal Vaccines

 

ICHIDA, JUSTIN KAWIKA (contact); GOODARZI, HANI

 

UNIVERSITY OF SOUTHERN CALIFORNIA

 

Leveraging Natural Phenotypic Variations of Heterogenous ALS Populations-in-a-Dish to Enable Scalable Drug Discovery

 

VAN RYZIN, MARK J

 

UNIVERSITY OF OREGON

 

Transforming Adolescent Mental Health Through Accessible, Scalable, Technology-Supported Small-Group Instruction

 

ZINN, KAI G (contact); GARCIA, KENAN CHRISTOPHER; THOMSON, MATTHEW

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

A Global Map of Interactions Among Human Cell Surface Proteins and Secreted Ligands

 

2021 NIH Director's Transformative Research Award (R01)

RFA-RM-20-013

*Diversity Statement

PI Name Institution Name Title
BELLAMKONDA, RAVI V

 

DUKE UNIVERSITY

 

Tumor Tractor Beam for Diffuse Cancers
BLACK, BEN E (contact); LAMPSON, MICHAEL

 

UNIVERSITY OF PENNSYLVANIA

 

Mendelian Inheritance of Artificial Chromosomes
GITAI, ZEMER (contact); ABOU DONIA, MOHAMED; MURPHY, COLEEN TARA

 

PRINCETON UNIVERSITY

 

Small RNAs as Novel Modulators of Microbe-Host Interactions
KIMBRO, KEVIN SEAN (contact); NAVARRO, HERNAN A; WILLIAMS, KEVIN PETER

 

NORTH CAROLINA CENTRAL UNIVERSITY

 

Addressing the Biology of Health Disparities by Targeting Geographical Ancestry-Driven Variants of Immunity
NAAR, SYLVIE (contact); ANDERSON, NORMAN B; PETTUS-DAVIS, CARRIE

 

FLORIDA STATE UNIVERSITY

 

Transforming Health Equity Research in Integrated Primary Care: Antiracism as a Disruptive Innovation
OKWAN-DUODU, DERICK

 

CEDARS-SINAI MEDICAL CENTER

 

High Dimensional Atlas of Circulating Neutrophils as Reporters of Solid Organ Functional Status
POSPISILIK, JOHN ANDREW (contact); NADEAU, JOSEPH H

 

VAN ANDEL RESEARCH INSTITUTE

 

Master Regulators of Unexplained Variation in Disease Risk
ROBERTS, TODD F (contact); HAMRA, F KENT; TAKAHASHI, JOSEPH S

 

UT SOUTHWESTERN MEDICAL CENTER

 

The Genetic Basis of Vocal Learning
WESEMANN, DUANE R

 

BRIGHAM AND WOMEN'S HOSPITAL

 

Flipped Germinal Centers
YUN, SEOK-HYUN ANDY

 

MASSACHUSETTS GENERAL HOSPITAL

 

Laser Particles for Multi-Dimensional Single-Cell Analysis

 

2021 NIH Director's Transformative Research Award (R01) Amyotrophic Lateral Sclerosis (ALS) Awards - NOT-RM-20-019

The Accelerating Leading-edge Science in ALS (ALS2) initiative issued an opportunity to support ALS research through several Transformative Research Awards. The initiative aims to dramatically advance the understanding of what triggers and drives the rapid progression of ALS.

PI Name Institution Name Title
DONNELLY, CHRISTOPHER JAMES (contact); BELZIL, VERONIQUE; HEIMAN, MYRIAM; KELLIS, MANOLIS

 

UNIVERSITY OF PITTSBURGH AT PITTSBURGH

 

Identification of TDP-43 Modifiers Through Single-Cell Transcriptional and Epigenomic Dissection of ALS and FTLD-MND
FELDMAN, EVA LUCILLE (contact); BATTERMAN, STUART A; GOUTMAN, STEPHEN; SARTOR, MAUREEN AGNES

 

UNIVERSITY OF MICHIGAN AT ANN ARBOR

 

Developing Novel Strategies for Personalized Treatment and Prevention of ALS: Leveraging the Global Exposome, Genome, Epigenome, Metabolome, and Inflammasome with Data Science in a Case/Control Cohort
LU, QUN

 

EAST CAROLINA UNIVERSITY

 

Homeostatic Reset as a New Therapeutic Paradigm for Slow Progression Diseases
PHATNANI, HEMALI (contact); HOLT, LIAM JOSEPH; YAMAMOTO, AI

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

The Physical Biology of Neurodegeneration in Sporadic Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

 

2021 NIH Director's Transformative Research Award (R01) Emergency COVID-19 Awards - RFA-RM-20-020

Due to the public health emergency, the Transformative Research Award and Early Independence Award issued additional funding opportunities for COVID-19-related research on the prevention of, preparation for, or response to coronavirus SARS-CoV-2 using funds provided through the CARES Act.

PI Name Institution Name Title
DEB, ARJUN (contact); ARUMUGASWAMI, VAITHILINGARAJA; GRAEBER, THOMAS G; PELLEGRINI, MATTEO

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Metabolic and Epigenetic Reprogramming of Vital Organs in SARS-CoV-2 Induced Systemic Toxicity
MANCEBO, RICARDO

 

GENENDEAVOR, LLC

 

Development of a Handheld Rapid Air Sensing System to Monitor and Quantify SARS-CoV-2 in Aerosols in Real-Time
RAY, ANIMESH (contact); HERNANDEZ, JENIFFER BERTHA

 

KECK GRADUATE INST OF APPLIED LIFE SCIS

 

Rapid Response for Pandemics: Single Cell Sequencing and Deep Learning to Predict Antibody Sequences Against an Emerging Antigen
WEINBERGER, LEOR S (contact); RODICK, ROBERT

 

VXBIOSCIENCES, INC.

 

Autonomously Deploying, Co-Evolving SARS-CoV-2 Antiviral: A New Paradigm for Pandemic Prevention
YAKOUB, ABRAAM M (contact); LAZARTIGUES, ERIC D; TSENG, CHIEN-TE K

 

UNIVERSITY OF NORTH DAKOTA

 

SARS-CoV-2 Tropism in the Brain and Its Relationship to COVID-19 Pathogenesis
2020 NIH Director's Transformative Research Award (R01)

RFA-RM-19-007

*Diversity Statement

PI Name Institution Name Title
ADAMS, PETER D

 

SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

 

Defining Chromostasis - A Candidate Regulator of Healthy Aging and Longevity

 

BASS, BRENDA L (contact); ELDE, NELS C; JACKMAN, JANE ELIZABETH; STETSON, DANIEL B

 

UNIVERSITY OF UTAH

 

Unlocking Evolutionarily Latent Immune Functions for Treating Disease

 

BROWN, BRIAN D

 

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

 

Development of a Platform for Spatial Functional Genomics

 

CHUN, JEROLD

 

SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

 

Transformative Research on Somatic Gene Recombination in the Normal and Alzheimers Disease-Related Dementia Brain

 

DITTEL, BONNIE N

 

VERSITI WISCONSIN, INC.

 

Development of a B Cell Therapeutic

 

GUTTMAN, MITCHELL

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

How Phase-Separation in the Nucleus Organizes 3D Spatial Assembly and Gene Regulation

 

HEDSTROM, LIZBETH K

 

BRANDEIS UNIVERSITY

 

Ubiquitin-Independent Targeted Protein Degradation

 

HESSELBERTH, JAY R

 

UNIVERSITY OF COLORADO DENVER

 

Biochemistry at Single-Cell Resolution: A New Approach to Understand Functional Heterogeneity

 

LIU, CHANG C (contact); KRUSE, ANDREW; MARKS, DEBORA S

 

UNIVERSITY OF CALIFORNIA-IRVINE

 

Making Antibody Generation Rapid, Scalable, and Democratic Through Machine Learning and Continuous Evolution

 

2019 NIH Director's Transformative Research Award (R01)

RFA-RM-18-009

*Advisory Committee to the NIH Director Working Group Findings

PI Name Institution Name Title
BREM, RACHEL BETH (contact); BAUTISTA, DIANA MICHELE; ELLERBY, LISA M; VERDIN, ERIC M

 

BUCK INSTITUTE FOR RESEARCH ON AGING

 

Genetic Dissection of Trait Variation Between Long-Diverged Mouse Species

 

CHAIT, BRIAN T

 

ROCKEFELLER UNIVERSITY

 

Development of Next Generation Mass Spectrometric Instrumentation for Proteomics

 

DEDON, PETER C (contact); ALM, ERIC JOHN

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Epigenetics of the Human Gut Microbiome

 

DENNY, CHRISTINE ANN (contact); RAMIREZ, STEVE

 

NEW YORK STATE PSYCHIATRIC INSTITUTE

 

Single-Cell and Target-Specific Resolution of Multiple Memories Across the Brain

 

GEISSMANN, FREDERIC

 

SLOAN-KETTERING INST CAN RESEARCH

 

Role of Microglia Somatic Variants in Neurodegenerative Diseases

 

GLADYSHEV, VADIM N

 

BRIGHAM AND WOMEN'S HOSPITAL

 

Unbiased Identification of Interventions that Extend Lifespan

 

JARVIS, ERICH D

 

ROCKEFELLER UNIVERSITY

 

Neuroengineering a Robust Vocal Learning Phenotype in Mice as a Model for Treating Communication Disorders

 

RAJ, ARJUN (contact); JAIN, RAJAN

 

UNIVERSITY OF PENNSYLVANIA

 

Decoding the Bridges and Barriers to Cellular Reprogramming and Lineage Identity

 

SHEPHERD, JASON D (contact); CAMPBELL, EDWARD M; GALLAGHER, THOMAS MILLER

 

UNIVERSITY OF UTAH

 

Virus-Like Intercellular Communication in the Nervous System

 

2018 NIH Director's Transformative Research Award (R01)

RFA-RM-17-007

*Commitment to Diversity

PI Name Institution Name Title
ALBEANU, DINU FLORENTIN (contact); KOULAKOV, ALEXEI

 

COLD SPRING HARBOR LABORATORY

 

A High-Throughput Sequencing and Imaging Approach to Understand the Functional Basis of Olfaction

 

DEISSEROTH, KARL A (contact); BRUNET, ANNE

 

STANFORD UNIVERSITY

 

Brain-Wide Screen for a Neural Pacemaker of Aging

 

KODADEK, THOMAS J

 

SCRIPPS FLORIDA

 

Phenotypic Screening Using DNA-Encoded Libraries

 

KORNBERG, ROGER D

 

STANFORD UNIVERSITY

 

Three-Dimensional Structure of Eukaryote Chromosomes

 

LEE, RICHARD T

 

HARVARD UNIVERSITY

 

Novel Age-Dependent DNA Modifications

 

PAYNE, AIMEE S (contact); MASON, NICOLA J

 

UNIVERSITY OF PENNSYLVANIA

 

Translating Cellular Immunotherapies for Autoimmunity to Canine Clinical Trials

 

PERRIMON, NORBERT (contact); CARR, STEVEN A; MCMAHON, ANDREW P; TING, ALICE Y

 

HARVARD MEDICAL SCHOOL

 

Mapping Protein Communication Between Organs in Homeostasis and Disease

 

SCHIFF, STEVEN J

 

PENNSYLVANIA STATE UNIV HERSHEY MED CTR

 

Predictive Personalized Public Health (P3H): A Novel Paradigm to Treat Infectious Disease

 

STRICK, PETER

 

UNIVERSITY OF PITTSBURGH AT PITTSBURGH

 

The Neural Basis of the Brain-Body Connection

 

TRAVER, DAVID (contact); BAO, ZHIRONG; HUISKEN, JAN

 

UNIVERSITY OF CALIFORNIA, SAN DIEGO

 

An Integrative Cellular Blueprint of Vertebrate Tissue Development

 

2017 NIH Director's Transformative Research Award (R01)

RFA-RM-16-007

*Statement on Diversity

PI Name Institution Name Title
ANDREWS, ANNE MILASINCIC

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Micro- to Nanoscale Neurochemical Sensors

 

BENNER, STEVEN A

 

FOUNDATION FOR APPLIED MOLECULAR EVOLUTN

 

Transforming Life Sciences: Artificial Life

 

BOYDEN, EDWARD S

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

High-Performance Imaging through Scattering Living Tissue

 

CHIU, DANIEL T (contact)
VAUGHAN, JOSHUA

 

UNIVERSITY OF WASHINGTON

 

Spatially Resolved Transcriptomics Enabled by Ultrabright Pdot Probes for Interrogation of Complex Tissues

 

DAVIDSON, KARINA W

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

Re-engineering Precision Therapeutics through N-of-1 Trials

 

ELOWITZ, MICHAEL B (contact)

CAI, LONG

LOIS, CARLOS

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

MEMOIR: Recording, and In Situ Readout of Cell Lineage and Transcriptional History

 

JOHNSTON, CHRISTOPHER D

 

FORSYTH INSTITUTE

 

The SyngenicDNA and μPOET Platform: Overcoming Innate Barriers to Genetic Engineering in Bacteria

 

MUCIDA, DANIEL S

 

ROCKEFELLER UNIVERSITY

 

Functional Mapping of Enteric-Associated Neurons

 

2016 NIH Director's Transformative Research Award (R01)

RFA-RM-15-005

PI Name Institution Name Title

CHOUDHARY, AMIT (contact)

SECOR, STEPHEN M

WAGNER, BRIDGET K

 

BROAD INSTITUTE, INC.

 

Leveraging Snakes Extreme Physiology to Modulate Human Beta-Cell Function

 

HEDRICK, STEPHEN M (contact)

BIER, ETHAN

GOLDRATH, ANANDA W

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Mutagenic Chain Reaction-Facilitated Immunotherapy

 

LESSER, CAMMIE (contact)

GARRETT, WENDY S.

LEONG, JOHN M

 

MASSACHUSETTS GENERAL HOSPITAL

 

Designer Probiotics for the Treatment of Intestinal Infection and Inflammation

 

LESTER, HENRY A.

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Fluorescent Biosensors for Subcellular Pharmacokinetics

 

MAGGERT, KEITH A

 

UNIVERSITY OF ARIZONA

 

Induced Transgenerational Inheritance without Epigenetics

 

RANGANATHAN, RAMA

 

UT SOUTHWESTERN MEDICAL CENTER

 

Seeing Protein Mechanics: The Link between Molecular Structure, Function, and Evolution

 

RIENSTRA, CHAD M (contact)

MORRISSEY, JAMES H.

TAJKHORSHID, EMAD

 

UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN

 

Toolkit for High-Resolution Structure and Dynamics of Functional Lipids

 

WOOLLEY, CATHERINE S

 

NORTHWESTERN UNIVERSITY

 

New Tools to Study Neurosteroid Estrogens

 

WU, CHAO-TING

 

HARVARD MEDICAL SCHOOL

 

Culling the Human Genome of Disease Variants Using Ultraconserved Elements

 

YANKNER, BRUCE A (contact)

CHURCH, GEORGE M

 

HARVARD MEDICAL SCHOOL

 

Exploring a Novel Paradigm of Schizophrenia and Bipolar Disorder

 

ZHANG, XIAOJING

 

DARTMOUTH COLLEGE

 

Implantable Cardiac Power Generation Using Flexible 3D Porous Thin Films

 

ZHUANG, XIAOWEI (contact)
DULAC, CA

THERINE G

 

HARVARD UNIVERSITY

 

In Situ Transcriptome Imaging in Single Cells

 

2015 NIH Director's Transformative Research Award (R01)

RFA-RM-14-003

PI Name Institution Name Title

ALLBRITTON, NANCY L. (contact)

BULTMAN, SCOTT J

GOMEZ, SHAWN MICHAEL

MAGNESS, SCOTT T

 

UNIV OF NORTH CAROLINA CHAPEL HILL

 

Development of Human Intestinal Simulacra

 

BADAWI, RAMSEY D. (contact)

CHERRY, SIMON R

 

UNIVERSITY OF CALIFORNIA AT DAVIS

 

EXPLORER: Changing the Molecular Imaging Paradigm with Total Body PET

 

BARKER, THOMAS HARRISON

 

GEORGIA INSTITUTE OF TECHNOLOGY

 

Mechanosensors that Detect and Treat Lung Fibrosis

 

DOLINOY, DANA

 

UNIVERSITY OF MICHIGAN

 

Development of piRNAs for Target-Specific Methylation

 

HETZER, MARTIN W

 

SALK INSTITUTE FOR BIOLOGICAL STUDIES

 

The Role of Long-Lived Proteins in the Survival of Nerve Cells

 

HOTOPP, JULIE

 

UNIVERSITY OF MARYLAND BALTIMORE

 

Extent and Significance of Bacterial DNA Integrations in the Human Cancer Genome

 

TAVAZOIE, SAEED F

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

Massively Parallel Mapping of All Molecular Interactions in a Single Tube

 

ZHANG, FENG

 

BROAD INSTITUTE, INC.

 

Massively-Parallel Functional Interrogation of Psychiatric Genetics

 

2014 NIH Director's Transformative Research Award (R01)

RFA-RM-13-008

PI Name Institution Name Title

ARNOLD, DONALD B (contact)

FRASER, SCOTT E

KESSELMAN, CARL

 

UNIVERSITY OF SOUTHERN CALIFORNIA

 

Dynamic Mapping of the Complete Synaptome Using Recombinant Probes

 

GIMELBRANT, ALEXANDER

 

DANA-FARBER CANCER INSTITUTE

 

Mechanism and Function of Autosomal Analog of X Inactivation

 

JAIN, SANJAY

 

JOHNS HOPKINS UNIVERSITY

 

Novel Imaging Tracers for Rapid and Noninvasive Assessment of Bacterial Infection

 

KIM, DENNIS H (contact)

SCHROEDER, FRANK CLEMENS

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Antimicrobial Discovery from Metabolomics of Nematode Pathogen Interactions

 

LIM, WENDELL A

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Redesigning the T cell: Using Synthetic Biology to Engineer Therapeutic Cells

 

MCMANUS, MICHAEL T

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Tracing Cell Lineages

 

MOCARSKI, EDWARD S.

 

EMORY UNIVERSITY

 

Innate Activation and Death Signals in Health and Disease

 

RAFII, SHAHIN

 

WEILL MEDICAL COLL OF CORNELL UNIV

 

Deciphering Molecular Determinants of Vascular Heterogeneity for Organ Repair

 

SMITH, STEPHEN J (contact)

BURNS, RANDAL

 

ALLEN INSTITUTE OF BRAIN SCIENCE

 

Synaptomes of Mouse and Man

 

2013 NIH Director's Transformative Research Award (R01)

RFA-RM-12-017

PI Name Institution Name Title

CARNES, MOLLY L (contact)

DEVINE, PATRICIA G

FORD, CECILIA E

 

UNIVERSITY OF WISCONSIN-MADISON

 

Exploring the Science of Scientific Review

 

KORDING, KONRAD P. (contact)

BOYDEN, EDWARD S.

CHURCH, GEORGE M

 

REHABILITATION INSTITUTE OF CHICAGO

 

Recording Neural Activities onto DNA

 

MANDEL, GAIL (contact)

ADELMAN, JOHN P

BREHM, PAUL

ROSENTHAL, JOSHUA J.C.

 

OREGON HEALTH AND SCI UNIVERSITY

 

Site-Directed RNA Editing: A New Method to Correct Disease Causing Mutations

 

OCHOA, AUGUSTO C

 

LOUISIANA STATE UNIV HSC NEW ORLEANS

 

Metabolic Approaches to Treat Severe Viral and Inflammatory Diseases

 

RELMAN, DAVID ARNOLD (contact)

HOLMES, SUSAN P

 

PALO ALTO INSTITUTE FOR RES & EDU, INC.

 

Predicting Resilience in the Human Microbiome

 

TING, ALICE Y

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Spatially-Resolved Proteomic Mapping of Living Cells

 

WANG, LIHONG

 

WASHINGTON UNIVERSITY

 

In Vivo Imaging of Single Circulating Cells

 

WYSSCORAY, TONY (contact)

RANDO, THOMAS A.

 

PALO ALTO INSTITUTE FOR RES & EDU, INC.

 

A New Muscle-Brain Axis Underlying the Cognitive Benefits of Physical Activity

 

YANNOPOULOS, DEMETRI

 

UNIVERSITY OF MINNESOTA

 

Reperfusion Injury Protection Strategies during Basic Life Support

 

YIN, PENG

 

HARVARD UNIVERSITY (MEDICAL SCHOOL)

 

Super-Resolution Imaging via Programmable Autonomous Blinking

 

2012 NIH Director's Transformative Research Award (R01)

RFA-RM-11-006

PI Name Institution Name Title
ABELIOVICH, ASA

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

Generation and Integration of New CNS Neurons by In Vivo Directed Conversion

 

ALLISON, DAVID B

 

UNIVERSITY OF ALABAMA BIRMINGHAM

 

Energetics, Disparities, & Lifespan: A Unified Hypothesis

 

ALTSHULER, DAVID (contact)

COWAN, CHAD ALBERT

 

THE BROAD INSTITUTE, INC.

 

Isogenic Human Pluripotent Stem Cell-Based Models of Human Disease Mutations

 

BARRES, BEN A

 

STANFORD UNIVERSITY

 

An Astrocytic Basis for Humanity

 

BLAU, HELEN M

 

STANFORD UNIVERSITY

 

Telomere Extension Using Nucleoside-Modified mRNA and Exosomes as a Novel Therape

 

BROWN, EMERY N. (contact)

BOYDEN, EDWARD S.

SOLT, KEN

WILSON, MATTHEW A.

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Redesigning General Anesthesia

 

CHRISTMAN, KAREN L (contact)

GIANNESCHI, NATHAN CLAUDE

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Autonomously Assembling Nanomaterial Scaffolds for Treating Myocardial Infarction

 

DARNELL, ROBERT B

 

THE ROCKEFELLER UNIVERSITY

 

Mapping the Mechanisms of Protein Synthesis-Dependent Synaptic Plasticity

 

DEISSEROTH, KARL ALEXANDER

 

STANFORD UNIVERSITY

 

CLARITY: Fully-Assembled Biology

 

GEREAU, ROBERT W (contact)

BRUCHAS, MICHAEL R

ROGERS, JOHN

 

WASHINGTON UNIVERSITY

 

Multimodal Biocompatible MicroLED Devices for Diverse Neuroscience Applications

 

GLASS, CHRISTOPHER K

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Enhancer Therapy

 

MARASCO, PAUL

 

CLEVELAND VA MEDICAL RESEARCH/ED/FDN

 

Restoring Upper Limb Movement Sense to Amputees; A Move towards Natural Control of Prosthetic Limbs

 

NEWMAN, DIANNE K

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Geobiological Approaches to Understanding Pulmonary Infections In Situ

 

SHEA, LONNIE D (contact)

BACKMAN, VADIM

 

NORTHWESTERN UNIVERSITY

 

An In Vivo Metastasis Sensor

 

SHEVKOPLYAS, SERGEY S

 

TULANE UNIVERSITY OF LOUISIANA

 

Eliminating Mediators of Toxicity from Stored Blood

 

STOJANOVIC, MILAN N (contact)

YAN, HAO

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

Theranostic Nano-objects: Basic Principles and Initial Applications

 

TUSCHL, THOMAS (contact)

OHLER, UWE

PATEL, DINSHAW J

 

THE ROCKEFELLER UNIVERSITY

 

Posttranscriptional Regulation by mRNA-Binding Shuttling and Transport Proteins

 

WEINER, HOWARD L

 

BRIGHAM AND WOMEN'S HOSPITAL, INC

 

Role of the Innate Immune System in Aging and Development of Alzheimer's Disease

 

WISNIEWSKI, NATALIE ANN (contact)

MCSHANE, MIKE

 

PROFUSA, INC.

 

Implantable Multi-Analyte Sensors for the Continuous Monitoring of Body Chemistries

 

WUCHERPFENNIG, KAI W (contact)

GOTTSCHALK, STEPHEN

 

DANA-FARBER CANCER INSTITUTE

 

Reprogramming of T cells for the Treatment of Melanoma

 

2011 NIH Director's Transformative Research Award (R01)

RFA-RM-10-010

PI Name Institution Name Title

BEN-YAKAR, ADELA (contact)

PIERCE-SHIMOMURA, JONATHAN T

 

UNIVERSITY OF TEXAS AUSTIN

 

High-Speed Opto-Fluidics to Screen Entire Nervous System in Aging and Disease

 

BOAHEN, KWABENA

 

STANFORD UNIVERSITY

 

Fully Implantable and Programmable Spike-based Codecs for Neuroprosthetics

 

GAGE, FRED H

 

SALK INSTITUTE FOR BIOLOGICAL STUDIES

 

Single-Cell Approaches to Reveal How Jumping Genes Individualize Neural Circuits

 

HARTUNG, THOMAS

 

JOHNS HOPKINS UNIVERSITY

 

Mapping the Human Toxome by Systems Toxicology
HONKANEN, RICHARD E

 

UNIVERSITY OF SOUTH ALABAMA

 

Methods to Enable Cholesterol Catabolism in Human Monocyte Derived Macrophages
JASANOFF, ALAN

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Noninvasive Imaging-Based Electrophysiology Using Microelectronic Devices

KUPPER, THOMAS S

CLARK, RACHAEL ANN

BRIGHAM AND WOMEN'S HOSPITAL

 

Vaccination to Generate Protective Tissue Resident T Cells

 

LECKMAN, JAMES F (contact)

WEXLER, BRUCE E.

 

YALE UNIVERSITY

 

Integrated Brain, Body and Social Intervention for ADHD

 

LICHTMAN, JEFF W (contact)

MEISTER, MARKUS

SANES, JOSHUA R

SEUNG, H SEBASTIAN

 

HARVARD UNIVERSITY

 

High Resolution Connectomics of Mammalian Neural Circuits

LIN, HENING (contact)

CERIONE, RICHARD A

WEISS, ROBERT S

 

CORNELL UNIVERSITY ITHACA

 

Succinylation and Malonylation as Novel Protein Modifications in Cancer

 

MCDEVITT, TODD C

 

GEORGIA INSTITUTE OF TECHNOLOGY

 

Stem Cell Morphogen Delivery via Engineered Biomaterials
MOOTHA, VAMSI KRISHNA

 

MASSACHUSETTS GENERAL HOSPITAL

 

Molecular Prostheses for Mitochondrial Disorders

 

NIE, SHUMING (contact)

SINGHAL, SUNIL

 

EMORY UNIVERSITY

 

Contrast-Enhanced and Image-Guided Surgery of Lung Cancer

 

NOLTA, JAN A

 

UNIVERSITY OF CALIFORNIA DAVIS

 

Direct Cell to Cell Transfer of microRNA for Tissue Repair
PAPAVASILIOU, F NINA

 

ROCKEFELLER UNIVERSITY

 

Building Novel Vaccines on a Borrowed Coat

 

PUGLISI, JOSEPH D

 

STANFORD UNIVERSITY

 

Single Molecule Translational Profiling

ROSS, MARGARET

ELIZABETH (contact)

MASON, CHRISTOPHER EDWARD

 

WEILL MEDICAL COLLEGE OF CORNELL UNIV

 

Epigenome Interactions in Complex Neurogenetic Disorders

 

2010 NIH Director's Transformative Research Award (R01)

RFA-RM-09-022

PI Name Institution Name Title

ARLOTTA, PAOLA (contact)

JOUNG, J. KEITH

ZHANG, FENG

 

MASSACHUSETTS GENERAL HOSPITAL

 

Genome-Wide Light-Inducible Tuning of Transcriptional Network Dynamic

 

BLASER, MARTIN J

 

NEW YORK UNIVERSITY SCHOOL OF MEDICINE

 

Disappearing Gastrointestinal Microbiota in Epidemic Obesity

 

COUKOS, GEORGE

 

UNIVERSITY OF PENNSYLVANIA

 

Transformative Personalized Vascular Disrupting Cancer Immunotherapy

 

ELLINGTON, ANDREW D

 

UNIVERSITY OF TEXAS AUSTIN

 

DNA Circuits for Point-of-Care Diagnostics

 

FLAVELL, RICHARD A (contact)

DHODAPKAR, MADHAV V

MANZ, MARKUS G

 

YALE UNIVERSITY

 

Understanding Hemotopoietic Neoplasias Using Humanized Mice

 

GREEN, PAMELA J

 

UNIVERSITY OF DELAWARE

 

Global Analysis of the Human RNA Degradome

 

GRUTZENDLER, JAIME

 

NORTHWESTERN UNIVERSITY

 

Embolus Extravasation: An Alternative Mechanism of Microvascular Recanalization

 

KEATING, AMY E

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Very Large Datasets and New Models to Predict and Design Protein Interactions

 

NICKELS, BRYCE EDWARD (contact)

DOVE, SIMON L

 

RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK

 

NanoRNA-Mediated Control of Gene Expression

 

NICOLELIS, MIGUEL A. L.

 

DUKE UNIVERSITY

 

Dorsal Column Stimulation as a New Therapy for Motor Disorders

 

OLTZ, EUGENE M. (contact)

PAYTON, JACQUELINE E

 

WASHINGTON UNIVERSITY

 

Targeting Epigenomic Signatures in Non-Hodgkin Lymphoma for Novel Therapeutics

 

PELTZ, GARY A

 

STANFORD UNIVERSITY

 

Human Pharmacogenetics and Human Liver Regeneration

 

SHAHAM, SHAI

 

ROCKEFELLER UNIVERSITY

 

Glial Control of Neuronal Receptive Ending Morphology

 

WANG, LIGUO

 

YALE UNIVERSITY

 

Structure of a Membrane Protein in a Lipid Membrane: Cryo-EM Study of the HCN Cha

 

WEINER, DAVID B

 

UNIVERSITY OF PENNSYLVANIA

 

Development of a Universal Influenza Seasonal Vaccine

 

WERNIG, MARIUS (contact)

SUDHOF, THOMAS C

 

STANFORD UNIVERSITY

 

Direct Conversion of Fibroblasts into Neurons: A Novel Approach to Study Neuropsy

 

YANIK, MEHMET FATIH

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

High-Throughput In Vivo Subcellular-Resolution Vertebrate Screening Platform

 

ZADOR, ANTHONY M

 

COLD SPRING HARBOR LABORATORY

 

High-Throughput DNA Sequencing Method for Probing the Connectivity of Neural Circ

 

ZHANG, KANG (contact)

DING, SHENG

REH, THOMAS A

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Regeneration of Retinal Neurons by Chemically Induced Reprogramming of Muller Gli

ZHUANG, XIAOWEI (contact)

XIE, XIAOLIANG SUNNEY

 

HARVARD UNIVERSITY

 

Dynamic Cellular Architecture of Bacteria by System-Wide Super-Resolution Imaging

 

2009 NIH Director's Transformative Research Award (R01)

RFA-RM-08-029

PI Name Institution Name Title
AUSUBEL, FREDERICK M

 

MASSACHUSETTS GENERAL HOSPITAL

 

Identifying Novel Anti-Infectives by High Through-put Screening in Whole Animals

 

BRETON, SYLVIE

 

MASSACHUSETTS GENERAL HOSPITAL

 

3-Dimensional Modeling of Basal Cell Function in Pseudostratified Epithelia

 

CAMARERO, JULIO A

 

UNIVERSITY OF SOUTHERN CALIFORNIA

 

Cell-Based Screening and Selection of Cyclotide-Based Capture Reagents for Protei

 

COHEN, PINCHAS

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Novel Mitochondrially Encoded Peptides and Their Role in Health and Disease

 

CRAVATT, BENJAMIN F (contact)

KODADEK, THOMAS J

 

SCRIPPS RESEARCH INSTITUTE

 

Massively Parallel Identification of Protein Ligands

 

CZECH, MICHAEL P

 

UNIV OF MASSACHUSETTS MED SCH WORCESTER

 

Oral Delivery Vehicles for RNAi Therapies

 

DANUSER, GAUDENZ (contact)

HAHN, KLAUS M

 

HARVARD MEDICAL SCHOOL

 

Quantitative Imaging of Signaling Networks

 

DUBNAU, JOSHUA T

 

COLD SPRING HARBOR LABORATORY

 

Genome-Wide Regulatory Network Governing Neuronal mRNA Translation.

 

FIDOCK, DAVID ARMAND

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

Exploiting Fatty Acid Metabolism to Cure Malaria

 

GRIFFITH, LINDA G

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Perfused 3D Tissue Surrogates for Complex Cell-Cell Communication Systems

 

HOFFMAN, ANDREW R

 

PALO ALTO VETERANS INSTIT FOR RESEARCH

 

Role of Long-Range Chromatin Interactions in Genetic Disease

 

IYENGAR, SRINIVAS RAVI V
HE, JOHN C
HONE, JAMES C
LOEW, LESLIE M
ZAPH, SUSANA NEVES

 

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

 

Dynamics Underlying Tissue Integrity

 

JAFFREY, SAMIE R

 

WEILL MEDICAL COLL OF CORNELL UNIV

 

Novel Fluorescent Sensors for Simple, Sensitive, and Specific Protein Detection

 

JI, RU-RONG (contact)

SERHAN, CHARLES NICHOLAS

 

BRIGHAM AND WOMEN'S HOSPITAL

 

Resolvins, Protectins, and Chronic Pain Resolution.

 

KOIDE, SHOHEI

 

UNIVERSITY OF CHICAGO

 

Rational Generation of Directed Protein-Capture Reagents

 

KUO, CALVIN J

 

STANFORD UNIVERSITY

 

Three-Dimensional Scaffold-Based Systems for Primary Human Intestinal Culture

 

LAGASSE, ERIC

 

UNIVERSITY OF PITTSBURGH AT PITTSBURGH

 

Organogenesis of Ectopic Tissue in Lymph Node

 

LEE, BRENDAN

 

BAYLOR COLLEGE OF MEDICINE

 

Argininosuccinate Lyase Is an Essential Regulator of Systemic Nitric Oxide Produc

 

LEE, FRANK S

 

UNIVERSITY OF PENNSYLVANIA

 

The Hydroxylprolylproteome

 

LEWIS, KIM

 

NORTHEASTERN UNIVERSITY

 

Super-Persistent Cells and the Paradox of Untreatable Infections

 

LI, LONG-CHENG (contact)

LI, HAO

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Transcriptional Activation by Small RNA: Mechanism and Design Rules

 

LIS, JOHN T (contact)

CRAIGHEAD, HAROLD G

JIN, MOONSOO M

 

CORNELL UNIVERSITY

 

Development of High Throughput Aptamer-based Protein Capture/Detection Assays tow

 

MACIEJEWSKI, JAROSLAW P

 

CLEVELAND CLINIC LERNER COM-CWRU

 

Viral Pathogenesis of Idiopathic Bone Marrow Failure and Immune Cytopenias

 

MARGOLIS, PETER A (contact)

SEID, MICHAEL

 

CINCINNATI CHILDRENS HOSP MED CTR

 

Open Source Science: Transforming Chronic Illness Care

 

MARKOVITZ, DAVID MICHAEL

 

UNIVERSITY OF MICHIGAN

 

Replication of Human Endogenous Retroviruses in Modern Humans

 

MARKOWITZ, SANFORD D

 

CASE WESTERN RESERVE UNIVERSITY

 

Identifying Inborn Genetic Susceptibility to Development of Cancer Metastasis

 

MARSHALL, WALLACE

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Pattern Formation & Regeneration in a Single Cell

 

MCKNIGHT, STEVEN L (contact)

PIEPER, ANDREW A

 

UT SOUTHWESTERN MEDICAL CENTER

 

Discovery, Characterization and Preclinical Development of Pro-Neurogenic Drugs

 

MITRA, PARTHA PRATIM

 

COLD SPRING HARBOR LABORATORY

 

The Missing Circuit: The First Brainwide Connectivity Map for Mouse

 

MURDOCK, DEBORAH G

 

VANDERBILT UNIVERSITY

 

Fatty Acid Signals as Quorum Sensing Regulators of Mitochondrial Biogenesis

 

MURPHY, SHEILA T (contact)

BAEZCONDE-GARBANATI, LOURDES

ALBERTINA
BALL-ROKEACH, SANDRA

HAILE, ROBERT WILLIAM

 

UNIVERSITY OF SOUTHERN CALIFORNIA

 

Transforming Cancer Knowledge, Attitudes and Behavior through Narrative

 

NISWENDER, KEVIN D (contact)

GALLI, AURELIO

 

VANDERBILT UNIVERSITY

 

Insulin Regulation of Monoamine Signaling: Pathway to Obesity

 

PARSONNET, JULIE

 

STANFORD UNIVERSITY

 

Childhood Infection and Prevention of Obesity

 

POLLACK, GERALD H

 

UNIVERSITY OF WASHINGTON

 

Unexpectedly Profound Role of Water in Biology and Medicine

 

RICE, CHARLES M (contact)

BHATIA, SANGEETA N

 

ROCKEFELLER UNIVERSITY

 

Modeling Human Hepatotropic Infections in Complex Tissue Organoids

 

ROBERTS, RICHARD W (contact)

SOH, HYONGSOK TOM

 

UNIVERSITY OF SOUTHERN CALIFORNIA

 

Polypeptide Design with Proteomic Scope via Microfluidic mRNA Display

 

SUKI, BELA

 

BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

 

Regulatory Roles of Variable Mechanical Stimuli in Cell Function

 

TEWARI, MUNEESH

 

FRED HUTCHINSON CANCER RESEARCH CENTER

 

RNA as a Hormone: Systemic Signaling in Mammals via Circulating, Cell-Free Small

 

WALENSKY, LOREN DAVID

 

DANA-FARBER CANCER INST

 

A Lexicon of Stapled Peptide Helices Engineered to Capture the Protein Interactom

 

WILSON, ROBERT B

 

UNIVERSITY OF PENNSYLVANIA

 

Random shRNA Selection

 

WU, JOSEPH C

 

STANFORD UNIVERSITY

 

Re-Education of the Immune System for hES Cell Tolerance

 

XIE, XIAOLIANG SUNNEY

 

HARVARD UNIVERSITY

 

Imaging the Invisible with No Labels: A Major Opportunity in Biology and Medicine

 

ZYLKA, MARK J

 

UNIV OF NORTH CAROLINA CHAPEL HILL

 

Harnessing Ectonucleotidases to Treat Chronic Pain

 

This page last reviewed on October 3, 2023