Funded Research

2022 NIH Director's Pioneer Award (DP1) - RFA-RM-21-015

*Diversity Statement

PI Name Institution Name Title
CAI, LONG

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Single Cell Analysis of the Kinome

 

DZIRASA, KAFUI

 

DUKE UNIVERSITY

 

Precision Editing of Neural Circuits Using Engineered Electrical Synapses

 

KRISHNAN, YAMUNA

 

UNIVERSITY OF CHICAGO

 

Intracellular Electrophysiology: An Electrochemical Atlas of Organelles

 

KWONG, GABRIEL A

 

GEORGIA INSTITUTE OF TECHNOLOGY

 

Finding Sleeping Beauty: T Cell Biosensors for Dormant Cancer Detection

 

NELSON, CELESTE M

 

PRINCETON UNIVERSITY

 

Mechanical Clocks During Fetal Development

 

RANDLES, AMANDA E

 

DUKE UNIVERSITY

 

Dynamic Models of the Cardiovascular System Capturing Years, Rather Than Heartbeats

 

ROSE, SHERRI

 

STANFORD UNIVERSITY

 

A Framework for the Social Impact of Algorithms in Health Care

 

SAWYER, SARA

 

UNIVERSITY OF COLORADO

 

Breaking the Barrier to an HIV Vaccine

 

 

2021 NIH Director's Pioneer Award (DP1) - RFA-RM-20-011

*Diversity Statement

PI Name Institution Name Title
ANIKEEVA, POLINA O

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Fusion of Nanomagnetic and Viral Tools to Interrogate Brain-Body Circuits

 

CLARK, PATRICIA LOUISE

 

UNIVERSITY OF NOTRE DAME

 

Decoding the Regulation of Protein Folding by Synonymous Codon Usage

 

COSTA, RUI M

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

Brain Control of Internal Organ Function

 

GACK, MICHAELA ULRIKE

 

CLEVELAND CLINIC LERNER COM-CWRU

 

Defining the Viral PTMome: Towards the Development of Novel Antiviral Approaches

 

HIGLEY, MICHAEL JAMES

 

YALE UNIVERSITY

 

Bridging Cellular and Systems Neuroscience: Synaptic Dynamics Underlying Behavior

 

HUANG, Z JOSH

 

DUKE UNIVERSITY

 

RNA-Programmable Cell-Type Targeting, Editing, and Therapy

 

MURPHY, COLEEN TARA

 

PRINCETON UNIVERSITY

 

Cracking the Code of Transgenerational Inheritance of Behavior

 

PHILLIPS-CREMINS, JENNIFER ELIZABETH

 

UNIVERSITY OF PENNSYLVANIA

 

From 3D Genomes to Neural Connectomes: Higher-Order Chromatin Mechanisms Encoding Long-Term Memory

 

RICHARDS, LINDA J

 

WASHINGTON UNIVERSITY

 

Emergence of Activity Patterns in the Cerebral Cortex and Their Influence on Brain Circuit Development and Function

 

SHAPIRO, MIKHAIL

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Sonogenetic Remote Control of Cellular Function

 

 

2020 NIH Director's Pioneer Award (DP1) - RFA-RM-19-005

*Diversity Statement

PI Name Institution Name Title
BARRON, ANNELISE EMILY

 

STANFORD UNIVERSITY

 

Role of Innate Immune Dysregulation in the Etiology of Dementia

 

COLLINS, KATHLEEN

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

Human Genetic Supplementation Without Donor DNA or a DNA Break

 

HARVEY, CHRISTOPHER D

 

HARVARD MEDICAL SCHOOL

 

Toward Mechanistic Cognitive Neuroscience: Cell Types, Connectivity, and Patterned Perturbations

 

KIM, PETER S

 

STANFORD UNIVERSITY

 

Creating High-Resolution, Epitope-Focused Vaccines

 

LITT, BRIAN

 

UNIVERSITY OF PENNSYLVANIA

 

Ghost in the Machine: Melding Brain, Computer and Behavior

 

QIAN, SHU-BING

 

CORNELL UNIVERSITY

 

A Genetic Circuit Formed by Ribosomes

 

ROSENBERG, SUSAN M

 

BAYLOR COLLEGE OF MEDICINE

 

Harnessing Proteins as Drugs: the Protectome of Cancer- and Aging-Prevention Proteins

 

SCHOGGINS, JOHN W

 

UT SOUTHWESTERN MEDICAL CENTER

 

A Functional Evolutionary Genetic Approach to Combat Viral Infection

 

VEESLER, DAVID

 

UNIVERSITY OF WASHINGTON

 

Unraveling the Bat Humoral Immune Response Against Zoonotic Viruses to Guide the Design of Next-Generation Therapeutics

 

ZERNICKA-GOETZ, MAGDALENA

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Placental Models to Support Embryogenesis In Vitro

 

 

2019 NIH Director's Pioneer Award (DP1) - RFA-RM-18-007

*Advisory Committee to the NIH Director Working Group Findings

PI Name Institution Name Title
ANDERMANN, MARK L

 

BETH ISRAEL DEACONESS MEDICAL CENTER

 

Look Inward: Brainstem and Cortical Circuits for Boosting Interoceptive Attention

 

EBERWINE, JAMES H

 

UNIVERSITY OF PENNSYLVANIA

 

The Secret Lives of RNA: The In Vivo 3D-Structural Logic of Single Neuron RNA Metabolism

 

ELISSEEFF, JENNIFER H

 

JOHNS HOPKINS UNIVERSITY

 

Biomaterials-Directed Regenerative Immunotherapies

 

GRECO, VALENTINA

 

YALE UNIVERSITY

 

Defining the Role of Mutational Burden in Sustaining Normal Homeostasis During Aging

 

HERMAN, CHRISTOPHE

 

BAYLOR COLLEGE OF MEDICINE

 

A Synthetic Platform for Non-Antibiotic Eradication of Bacterial Infections

 

HUR, SUN

 

BOSTON CHILDREN'S HOSPITAL

 

Resolving Functional Aggregates: A New Perspective on Innate Immune Control

 

KNIGHT, ROB

 

UNIVERSITY OF CALIFORNIA, SAN DIEGO

 

Mapping Host-Microbe-Metabolite Interactions in 3D to Find Diet-Derived Enhancers of Immunity

 

LEE, JIN HYUNG

 

STANFORD UNIVERSITY

 

From Optogenetic Functional MRI to Mechanogenetic Functional Ultrasound

 

PICCIOTTO, MARINA R

 

YALE UNIVERSITY

 

Acetylcholine Signaling Allows Cognitive Processes in the Brain to Regulate Physiological Responses to the Environment: The Example of Central Control of Opiate Tolerance

 

PLOEGH, HIDDE L

 

BOSTON CHILDREN'S HOSPITAL

 

Imposing Order on the Family of Ubiquitin-Conjugating (E2) Enzymes Through Intracellular Perturbation with Nanobodies

 

SCHEURING, SIMON

 

WEILL MEDICAL COLL OF CORNELL UNIV

 

Enabling Physical Stimuli in the Study of Structural Dynamics: The Sensory Ion Channels

 

 

2018 NIH Director's Pioneer Award (DP1) - RFA-RM-17-005

*Commitment to Diversity

PI Name Institution Name Title
AYRES, JANELLE S

 

SALK INSTITUTE FOR BIOLOGICAL STUDIES

 

Host-Microbe Interactions: Harnessing Co-Evolution to Treat Disease

 

COLON-RAMOS, DANIEL A

 

YALE UNIVERSITY

 

Powering the Brain: The Cell Biology of Neuroenergetics

 

CURTIS, CHRISTINA N

 

STANFORD UNIVERSITY

 

Forecasting Tumor Evolution: Can the Past Reveal the Future?

 

GRADINARU, VIVIANA

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Circuit-Specific Delivery of Large Cargo Across the Nervous Systems of Adult Mammals and Embryos Via Novel Engineered Systemic Vectors

 

KIPNIS, JONATHAN

 

UNIVERSITY OF VIRGINIA

 

Neural Code of the Immune Responses

 

KWON, HYUNGBAE

 

MAX PLANCK FLORIDA CORPORATION

 

Cracking the Neuromodulation Code at Single Cell Resolution

 

MONJE-DEISSEROTH, MICHELLE

 

STANFORD UNIVERSITY

 

Glioma Circuitry: Bridging Systems Neuroscience and Cancer

 

VICTORA, GABRIEL D

 

ROCKEFELLER UNIVERSITY

 

Quantifying Cell-Cell Interactions in the Immune System by Trans-Synaptic Labeling

 

WAGERS, AMY JO

 

HARVARD UNIVERSITY

 

Uncovering Molecular Effectors of Mammalian Aging

 

YIN, PENG

 

HARVARD UNIVERSITY

 

High-Throughput Single-Molecule Protein Identification Via Super-Resolution Imaging

 

 

2017 NIH Director's Pioneer Award (DP1) - RFA-RM-16-005

*Statement on Diversity

PI Name Institution Name Title
DAI, HONGJIE

 

STANFORD UNIVERSITY

 

Human Infrared Vision at Molecular and Cellular Scale

 

ETKIN, AMIT

 

STANFORD UNIVERSITY

 

A “Circuits-First” Platform for Personalized Neurostimulation Treatment

 

FINE, HOWARD A

 

WEILL MEDICAL COLL OF CORNELL UNIV

 

Human Brain Cancer, Rather than Brain Cancer Cells, on a Plate

 

LIEBER, CHARLES M

 

HARVARD UNIVERSITY

 

Syringe-Injectable Mesh Electronics for Seamless Integration with the Central Nervous System

 

MACKLIS, JEFFREY D

 

HARVARD UNIVERSITY

 

Subcellular RNA-Proteome Mapping in Subtype- and Circuit-Specific Growth Cones: Development, Cell Biology, Disease, and Regeneration

 

MARRAFFINI, LUCIANO A

 

ROCKEFELLER UNIVERSITY

 

Generation of Immunological Memory by CRISPR-Cas Systems

 

SCHIER, ALEXANDER F

 

HARVARD UNIVERSITY

 

DNA-Mediated Recording of Cellular History

 

SHIEKHATTAR, RAMIN

 

UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

 

Enhancer RNA Therapy

 

SINCLAIR, DAVID A

 

HARVARD MEDICAL SCHOOL

 

Uncovering the Human Secretome

 

SONNENBURG, JUSTIN

 

STANFORD UNIVERSITY

 

Defining and Reconstructing the Human Ancestral Microbiome

 

TYE, KAY MAXINE

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Neural Circuit Mechanisms of Social Homeostasis in Individuals and Supraorganismal Social Groups

 

ZHANG, FENG

 

BROAD INSTITUTE, INC.

 

Exploration of Diverse Mobile Genetic Elements for Precision Genome Manipulation

 

 

2016 NIH Director's Pioneer Award (DP1) - RFA-RM-13-006

PI Name Institution Name Title
BALDWIN, KRISTIN KAY

 

SCRIPPS RESEARCH INSTITUTE

 

Defining a Transcriptional Periodic Table of the Human Brain Using Reprogramming

 

BERNSTEIN, BRADLEY EVAN

 

MASSACHUSETTS GENERAL HOSPITAL

 

Epigenetic Plasticity in Tumor Initiation and Evolution

 

FISCHBACH, MICHAEL ANDREW

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

A Complete Map of the Top 100 Molecules from the Gut Microbiome

 

HASSON, URI

 

PRINCETON UNIVERSITY

 

Speaker-Listener Coupling: A Novel Neural Approach for Assessing Communication

 

IZPISUA BELMONTE, JUAN CARLOS

 

SALK INSTITUTE FOR BIOLOGICAL STUDIES

 

Generation of Functional Human Organs and Tissues Using Interspecific Blastocyst Complementation

 

KANWISHER, NANCY

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

How Does the Functional Organization of the Human Brain Arise in Development?

 

LIBERLES, STEPHEN DANIEL

 

HARVARD MEDICAL SCHOOL

 

Sensory Receptors of the Vagus Nerve

 

MAYR, CHRISTINE

 

SLOAN-KETTERING INST CAN RESEARCH

 

3'UTR-Mediated Protein-Protein Interactions Determine Protein Functions

 

RABINOWITZ, JOSHUA D

 

PRINCETON UNIVERSITY

 

Metabolism in Action: Quantitative Fluxes in Mammals

 

WANG, MENG CARLA

 

BAYLOR COLLEGE OF MEDICINE

 

Decode the Chemical Language that Orchestrates Cellular and Organismal Homeostasis

 

WAY, SING SING

 

CINCINNATI CHILDRENS HOSP MED CTR

 

Immunological Identity Redefined by Genetically Foreign Microchimeric Cells

 

YUN, SEOK-HYUN ANDY

 

MASSACHUSETTS GENERAL HOSPITAL

 

Massive Wavelength-Division Multiplexing and Imaging with Laser Particles

 

 

2015 NIH Director's Pioneer Award (DP1) - RFA-RM-13-006

PI Name Institution Name Title
BOSCO, GIOVANNI

 

DARTMOUTH COLLEGE

 

Trans-Generational Effects of Social Learning?

 

COX, JEFFERY S

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Host-Directed Strategies to Create Synergistic Antibacterial Therapies

 

DISNEY, MATTHEW D

 

SCRIPPS FLORIDA

 

Using a Disease-Affected Cell to Synthesize Its Own Drug

 

GITAI, ZEMER

 

PRINCETON UNIVERSITY

 

Mechano-Microbiology: How Physical Forces Control Bacterial-Host Interactions

 

HOWARD, JONATHON

 

YALE UNIVERSITY

 

Cell Biological Limitations Constrain Dendritic Branching Morphology and Neuronal Function

 

MONTELL, CRAIG

 

UNIVERSITY OF CALIFORNIA SANTA BARBARA

 

Creation of a New Generation of Transgenic Mosquitoes to Control Infectious Disease

 

MURPHY, COLEEN TARA

 

PRINCETON UNIVERSITY

 

Toward the Tissue-ome: A Map of the C. elegans Cell-specific Transcriptome

 

RANDOLPH, GWENDALYN J

 

WASHINGTON UNIVERSITY

 

Integrating Cell & Lipoprotein Trafficking with Vascular Biology in Human IBD

 

SCHIFF, STEVEN J.

 

PENNSYLVANIA STATE UNIVERSITY

 

Control of the Neonatal Septisome and Hydrocephalus in Sub-Saharan Africa

 

WU, HAO

 

CHILDREN'S HOSPITAL CORPORATION

 

SMOCs: Novel Signal Transduction Complexes as New Targets for Drug Discovery

 

WYSS-CORAY, TONY

 

PALO ALTO VETERANS INSTIT FOR RESEARCH

 

A Bioorthogonal Approach to Study Mammalian Aging

 

YASUDA, RYOHEI

 

MAX PLANCK FLORIDA CORPORATION

 

Deciphering Biochemical Networks in Single Dendritic Spines

 

ZHONG, SHENG

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Mapping RNA interactomes by Sequencing

 

 

2014 NIH Director's Pioneer Award (DP1) - RFA-RM-13-006

PI Name Institution Name Title
AMBATI, JAYAKRISHNA

 

UNIVERSITY OF KENTUCKY

 

Form and Function of Our Janus Faced Genome

 

GU, CHENGHUA

 

HARVARD MEDICAL SCHOOL

 

New Tools for Understanding the Blood Brain Barrier

 

LAURENCIN, CATO T., MD, PHD

 

UNIVERSITY OF CONNECTICUT HEALTH CENTER

 

Regenerative Engineering of Complex Musculoskeletal Tissues and Joints

 

MONTELL, DENISE J.

 

UNIVERSITY OF CALIFORNIA SANTA BARBARA

 

Anastasis, a New Mechanism Driving Cell Survival and Evolution

 

NOVINA, CARL D

 

DANA-FARBER CANCER INSTITUTE

 

Engineering Epigenetic Therapy for Sickle Cell Disease

 

PALMER, AMY E

 

UNIVERSITY OF COLORADO

 

Regulation of Cell Signaling by Transition Metal Dynamics

 

PE'ER, DANA

 

COLUMBIA UNIV NEW YORK MORNINGSIDE

 

Single Cell Mapping of Developmental Trajectories Underlying Health and Disease

 

RANDO, OLIVER J

 

UNIV OF MASSACHUSETTS MED SCH WORCESTER

 

tRNA Fragments as Transgenerational Information Carriers

 

SPIEGELMAN, DONNA L

 

HARVARD SCHOOL OF PUBLIC HEALTH

 

Comprehensive Translational Science Analytics Tools for the Global Health Agenda

 

WU, SEAN M

 

STANFORD UNIVERSITY

 

Enabling Technologies for Human-Machine Hybrid Tissues

 

 

2013 NIH Director's Pioneer Award (DP1) - RFA-RM-12-015

PI Name Institution Name Title
ARNSTEN, AMY F.T.

 

YALE UNIVERSITY

 

Highly Evolved Brain Circuits in Primates: Molecular Vulnerabilities for Disease

 

BOYDEN, EDWARD S.

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Millisecond-Timescale Whole-Brain Neural Activity Mapping in Health and Disease

 

GLADYSHEV, VADIM N.

 

BRIGHAM AND WOMEN'S HOSPITAL

 

Mechanisms of Lifespan Control

 

KHAKH, BALJIT

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Astrocyte Branchlet Dysfunction as an Early Step in Brain Disorders

 

LIN, MICHAEL Z.

 

STANFORD UNIVERSITY

 

Optogenetics for All: A General Method for Optical Control of Protein Activity

 

SHENDURE, JAY ASHOK

 

UNIVERSITY OF WASHINGTON

 

Interpreting Genetic Variants of Uncertain Significance

 

TRAYANOVA, NATALIA A.

 

JOHNS HOPKINS UNIVERSITY

 

Virtual Electrophysiology Laboratory

 

WANG, FAN

 

DUKE UNIVERSITY

 

Toward Causal Neuroscience: Capture and Manipulate Emergent Neuronal Ensembles

 

WEINBERGER, LEOR S.

 

J. DAVID GLADSTONE INSTITUTES

 

Evolvable Resistance-Proof Therapies

 

XIE, XIAOLIANG SUNNEY

 

HARVARD UNIVERSITY

 

Probing Dynamics of the Human Genome by Single Cell Sequencing

 

YUSTE, RAFAEL M.

 

COLUMBIA UNIV NEW YORK MORNINGSIDE

 

Functional Connectomics of the Neocortical Microcircuit

 

ZYLKA, MARK J.

 

UNIV OF NORTH CAROLINA CHAPEL HILL

 

The Elongation Hypothesis of Autism

 

 

2012 NIH Director's Pioneer Award (DP1) - RFA-RM-11-004

PI Name Institution Name Title
BRUNET, ANNE

 

STANFORD UNIVERSITY

 

Transgenerational Epigenetic Inheritance of Longevity

 

MARCOTTE, EDWARD M

 

UNIVERSITY OF TEXAS AUSTIN

 

Next-Generation Proteomics: Massively Parallel Single-Molecule Protein Identification & Quantification

 

PLOEGH, HIDDE L

 

WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH

 

A New Strategy to Disrupt Protein-Protein Interactions in Eukaryotic Cells

 

SMOLKE, CHRISTINA D

 

STANFORD UNIVERSITY

 

Synthetic Biology Platforms for Natural Product Discovery and Biosynthesis

 

TANG, YI

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Rediscovering Natural Chemical Diversity

 

TSAO, DORIS YING

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Understanding the Circuit for Topological Object Tracking

 

WANG, LIHONG

 

WASHINGTON UNIVERSITY IN ST. LOUIS

 

Photon Tunneling: Shedding New Light on Biomedicine

 

WU, CHAO-TING

 

HARVARD UNIVERSITY

 

The Inheritance of Position: It's Not Just Who You Are, It's Where You Are

 

YELLEN, GARY I

 

HARVARD UNIVERSITY

 

Single Cell Analysis of Metabolism Using Genetically-Encoded Fluorescent Sensors

 

ZHANG, FENG

 

BROAD INSTITUTE, INC.

 

Probing Neuropsychiatric Diseases Using Targeted Epigenome and Genome Engineering

 

 

2011 NIH Director's Pioneer Award (DP1) - RFA-RM-10-008

PI Name Institution Name Title
BANERJEE, UTPAL

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Developmental Control of Metabolism

 

BASS, BRENDA L.

 

UNIVERSITY OF UTAH

 

Cellular Double-Stranded RNA as a Signal of Stress, Immunity, and Aging

 

BENNETT, JEAN

 

UNIVERSITY OF PENNSYLVANIA

 

Broad Spectrum Molecular Therapy for Blinding Retina Disorders

 

CLEMONS, WILLIAM M.

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

NIH Pioneer Award

 

ENGERT, FLORIAN

 

HARVARD UNIVERSITY

 

Watching a Vertebrate Brain Learn and Behave in a Virtual Environment

 

FEINBERG, ANDREW P

 

JOHNS HOPKINS UNIVERSITY

 

A General Stochastic Epigenetic Model for Evolution, Development, and Disease

 

HILDRETH, JAMES E.K.

 

MEHARRY MEDICAL COLLEGE

 

Role of Natural Pseudotyping with Other Viruses in HIV Transmission

 

PAN, TAO

 

UNIVERSITY OF CHICAGO

 

Mis-Translation as a New Mechanism of Stress Response in Biology

 

RAMANATHAN, SHARAD

 

HARVARD UNIVERSITY

 

A Road Map to the Neocortex

 

SCHNEIDER, DAVID S

 

STANFORD UNIVERSITY

 

Mapping the Road to Recovery - Does the Way We Get Better Differ from the Way We Get Sick?

 

SIAPAS, ATHANASSIOS G

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Nanoprobe Arrays for Massively Parallel 3-D Recordings of Brain Activity

 

TOLIAS, ANDREAS SAVAS

 

BAYLOR COLLEGE OF MEDICINE

 

Dissecting the Fabric of the Cerebral Cortex

 

YANIK, MEHMET FATIH

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Generating Transplantable Neurons by In Vivo Combinatorial Screening of Transcription Regulator RNAs

 

 

2010 NIH Director's Pioneer Award (DP1) - RFA-RM-09-010

PI Name Institution Name Title
BARBAS, CARLOS F

 

SCRIPPS RESEARCH INSTITUTE

 

Chemically Programmed Immunity

 

BJORKMAN, PAMELA J

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Thwarting HIV Evasion of Antibody Avidity with Novel Antibody Architectures

 

DRAGOI, VALENTIN

 

UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

 

Examining Population Coding Underlying Complex Behavior in Freely Moving Primates

 

FESIK, STEPHEN W

 

VANDERBILT UNIVERSITY MEDICAL CENTER

 

Expanding the Druggable Genome

 

HORVATH, TAMAS L

 

YALE UNIVERSITY

 

Hypothalamic AgRP Neurons Are Determinants of Healthy Lifespan and Higher Brain Functions

 

JOUNG, J. KEITH

 

MASSACHUSETTS GENERAL HOSPITAL

 

Advancing Stem Cell Technologies Using Engineered Zinc Finger Proteins

 

KLEINFELD, DAVID

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Defining the Logic of Neurovascular Signaling in the Brain

 

LIN, HAIFAN

 

YALE UNIVERSITY

 

Toward a Central Question in Epigenetics: A Major Epigenetic Programming Mechanism Guided by piRNAs

 

LIU, JUN O

 

JOHNS HOPKINS UNIVERSITY

 

Generation and Proteome-Wide Screening of Hybrid Combinatorial Libraries

 

MARICQ, ANDRES VILLU

 

UNIVERSITY OF UTAH

 

Simultaneous In Vivo Studies of Synapses, Neurons, and Learning and Memory

 

NADEAU, JOSEPH H

 

CASE WESTERN RESERVE UNIVERSITY

 

Lamarck Redux: Transgenerational Genetic Effects on Phenotypes and Disease

 

NICOLELIS, MIGUEL A. L.

 

DUKE UNIVERSITY

 

A Virtual Reality Simulator to Study VLSBA and Test Brain-Actuating Technologies

 

RAMAKRISHNAN, LALITA

 

UNIVERSITY OF WASHINGTON

 

Linking the Behavior of Individual Host Cells to Their Transcriptional Signatures

 

ROLE, LORNA W

 

THE RESEARCH FOUNDATION OF SUNY

 

Unveiling the Role and Taking Control of Cholinergic Tone in Circuits of Attention, Memory and Fear

 

ROUKES, MICHAEL L

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Nanoscale Tools to Push Biomedical Frontiers

 

SAMUDRALA, RAM

 

UNIVERSITY OF WASHINGTON

 

Novel Paradigms for Drug Discovery: Computational Multitarget Screening

 

YANKNER, BRUCE A

 

PRESIDENT AND FELLOWS OF HARVARD COLLEGE

 

Modeling the Aging Epigenome

 

 

2009 NIH Director's Pioneer Award (DP1) - RFA-RM-09-001

PI Name Institution Name Title
BENJAMIN, IVOR J

 

UNIVERSITY OF UTAH

 

Protein Misfolding Diseases and Oxido-Reductive Pathways

 

CHAWLA, AJAY

 

STANFORD UNIVERSITY

 

Immune Triggers of Tissue Regeneration

 

CHEN, CHANG-ZHENG

 

STANFORD UNIVERSITY

 

The Role of Pre-miRNA Loop in Target Regulation by microRNA Genes

 

CHEROUTRE, HILDE MC

 

LA JOLLA INST FOR ALLERGY & IMMUNOLGY

 

Uncovering the Missing Link that Determines Susceptibility to Autoimmunity

 

COVERT, MARKUS W

 

STANFORD UNIVERSITY

 

A Gene-Complete Computational Model of Yeast

 

DESIMONE, JOSEPH M

 

UNIV OF NORTH CAROLINA CHAPEL HILL

 

Delivery of Biological Therapeutics: Using Engineered Particles and Novel Delivery Methods to Address Unmet Needs

 

EVANS, SYLVIA M

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Approaches to Cardiac Regeneration

 

FETCHO, JOSEPH R

 

CORNELL UNIVERSITY

 

Global Changes in Synaptic Strength and Excitability During Sleep and Wakefulness

 

HOLY, TIMOTHY

 

WASHINGTON UNIVERSITY

 

Watching Action Potentials in Intact Neuronal Circuits

 

REYA, TANNISHTHA

 

DUKE UNIVERSITY

 

Imaging Self-Renewal and Transformation in Hematopoietic Stem Cells

 

ROBINSON, GENE E

 

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

 

Johnny Bee Good: Bees as Models to Study the Hijacking of the Reward System

 

ROSENBERG, SUSAN M

 

BAYLOR COLLEGE OF MEDICINE

 

Forward Genomics of Damage Control: An Undiscovered Class of Cancer Genes

 

SAMSON, LEONA D

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Developing Novel Methods to Measure DNA Repair Capacity in Human Populations

 

SHAH, NIRAO MAHESH

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Dissecting the Neural Control of Social Attachment

 

SHENOY, KRISHNA V

 

STANFORD UNIVERSITY

 

Toward an Animal Model of Freely Moving Human

 

TISHKOFF, SARAH ANNE

 

UNIVERSITY OF PENNSYLVANIA

 

African Odyssey: An Integrative Genomics Analysis of Complex Physiologic Traits

 

TRAVIS, ALEXANDER J

 

CORNELL UNIVERSITY

 

Nanoscale Energy Production for Implantable Medical Devices

 

ZHANG, JIN

 

JOHNS HOPKINS UNIVERSITY

 

Creating a Genetically Encodable Nano-Compass to Navigate in Molecular Networks

 

 

2008 NIH Director's Pioneer Award (DP1) - RFA-RM-08-013

PI Name Institution Name Title
CHEN, JAMES K

 

STANFORD UNIVERSITY

 

Chemical Embryology: Technologies for Manipulating and Visualizing Development

 

DOLMETSCH, RICARDO E

 

STANFORD UNIVERSITY

 

Using Induced Pluripotent Stem Cells to Identify Cellular Phenotypes of Autism

 

EBERWINE, JAMES H

 

UNIVERSITY OF PENNSYLVANIA

 

Cellular Logic of Phenotype

 

EPSTEIN, JOSHUA M

 

BROOKINGS INSTITUTION

 

Behavioral Epidemiology: Applications of Agent-Based Modeling to Infectious Disease

 

HAY, BRUCE A

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Engineering the Genetics of Wild Mosquito Populations to Fight Infectious Disease

 

HOCHSCHILD, ANN

 

HARVARD MEDICAL SCHOOL

 

A New Genetic Approach for Studying Prions and Other Pathogenic Protein Aggregate

 

LIEBER, CHARLES M

 

HARVARD UNIVERSITY

 

Nanowire Nanoelectronic/Cell Assemblies as Hybrid Functional Biomaterials

 

LONDON, BARRY

 

UNIVERSITY OF PITTSBURGH AT PITTSBURGH

 

In-Vivo Electrophysiology Imaging

 

MANIATIS, THOMAS P

 

HARVARD UNIVERSITY

 

Use of Induced Pluripotent Stem Cells to Study Mechanims of Familial and Sporadic ALS

 

ODOM, TERI WANG

 

NORTHWESTERN UNIVERSITY

 

Reconstructing Sub-cellular Structure Using Plasmonic Metamaterials

 

PARK, HONGKUN

 

HARVARD UNIVERSITY

 

Nano- and Microelectronic Tools for Interrogating Neuronal Circuits and Networks

 

REGEV, AVIV

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY | BROAD INSTITUTE, INC.

 

The Temporal Reconfiguration of Regulatory Networks: From Yeast to Cancer

 

SAMUEL, ARAVINTHAN D

 

HARVARD UNIVERSITY

 

Biophysical Approaches to Complex Navigational Behaviors in Larval Drosophila melanogaster

 

TAVAZOIE, SAEED F

 

PRINCETON UNIVERSITY

 

Towards a Cognitive Framework for Understanding Cellular Behavior

 

TING, ALICE Y

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Enabling the Study of Endogenous Proteins in Live Cells

 

VAN OUDENAARDEN, ALEXANDER

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Stochastic Gene Expression in Differentiation and Development

 

 

2007 NIH Director's Pioneer Award (DP1) - RFA-RM-07-005

PI Name Institution Name Title
BARRETT, LISA FELDMAN

 

BOSTON COLLEGE

 

Emotions Are Emergent Events Constrained by Affective and Conceptual Processes

 

BEARMAN, PETER SHAWN

 

COLUMBIA UNIV NEW YORK MORNINGSIDE

 

Social Determinants of the Autism Epidemic

 

BROWN, EMERY N

 

MASSACHUSETTS GENERAL HOSPITAL

 

A Systems Neuroscience Approach for the Study of General Anesthesia

 

CLANDININ, THOMAS ROBERT

 

STANFORD UNIVERSITY

 

Dissecting the Functional Anatomy of the Visual System: A New Way Forward

 

COLLINS, JAMES J

 

BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

 

A Network Biology Approach to Antibiotic Action and Bacterial Defense Mechanisms

 

GARDEL, MARGARET LISE

 

UNIVERSITY OF CHICAGO

 

2007 NIH Directors Pioneer Award Program (DP1)

 

HENSCH, TAKAO K

 

CHILDREN'S HOSPITAL CORPORATION

 

Dissecting Non-Coding RNA Function in Critical Period Brain Development/ Disorder

 

HORWITZ, MARSHALL S

 

UNIVERSITY OF WASHINGTON

 

NIH Directors Pioneer Award

 

ISMAGILOV, RUSTEM F

 

UNIVERSITY OF CHICAGO

 

2007 NIH Directors Pioneer Award Program (DP1)

 

JENSEN, FRANCES E

 

CHILDREN'S HOSPITAL CORPORATION

 

Understanding the Cognitive Impact of Early Life Epilepsy

 

SCHNITZER, MARK J

 

STANFORD UNIVERSITY

 

Massively Parallel Brain Imaging

 

TURRIGIANO, GINA G

 

BRANDEIS UNIVERSITY

 

Probing the Structure of the Synapse Using Superresolution Light Microscopy

 

 

2006 NIH Director's Pioneer Award (DP1) - RFA-RM-06-005

PI Name Institution Name Title
BOAHEN, KWABENA

 

STANFORD UNIVERSITY

 

Neurogrid: Emulating a Million Neurons in the Cortex

 

CHAKRABORTY, ARUP K.

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Developing the Principles Governing T Lymphocyte-Mediated Autoimmunity Using an Approach at an Intersection of the Physical and Life Sciences

 

GIERASCH, LILA M.

 

UNIVERSITY OF MASSACHUSETTS AMHERST

 

NIH Director's Pioneer Award Application

 

HEALD, REBECCA W.

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

NIH Director's Pioneer Award Application

 

KIRKEGAARD, KARLA A

 

STANFORD UNIVERSITY

 

Dominant Drug Targets in RNA Viruses

 

KODADEK, THOMAS

 

UNIVERSITY OF TEXAS SW MED CTR/DALLAS

 

Novel Chemistry to Monitor and Manipulate the Immune System

 

LEE, CHENG C

 

UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

 

Reversible Suspended Animation of Non-hibernating Mammals

 

NUDLER, EVGENY

 

NEW YORK UNIVERSITY SCHOOL OF MEDICINE

 

New Approaches to Fight Infection

 

PIELAK, GARY J.

 

UNIVERSITY OF NORTH CAROLINA CHAPEL HILL

 

In-Cell NMR of Disease-Related Proteins

 

RELMAN, DAVID A

 

STANFORD UNIVERSITY

 

NIH Director's Pioneer Award Application

 

SEGAL, ROSALIND A.

 

DANA-FARBER CANCER INSTITUTE

 

An Extended View of Self: Human Indigenous Microbial Communities in Health and Disease

 

SHERLEY, JAMES L

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Pioneering Human Adult Stem Cell Discovery and Cellular Medicine

 

XIA, YOUNAN

 

UNIVERSITY OF WASHINGTON

 

Put Nanostructures to Work for Reading and Controlling Cell Behavior

 

 

2005 NIH Director's Pioneer Award (DP1) - NOT-OD-05-021

PI Name Institution Name Title
CHANDLER, VICKI L

 

UNIVERSITY OF ARIZONA

 

NIH Director's Pioneer Award

 

CLINE, HOLLIS T

 

COLD SPRING HARBOR LABORATORY

 

NIH Director's Pioneer Award

 

COSMIDES, LEDA

 

UNIVERSITY OF CALIFORNIA SANTA BARBARA

 

NIH Director's Pioneer Award

 

DE LANGE, TITIA

 

ROCKEFELLER UNIVERSITY

 

NIH Director's Pioneer Award

 

DEISSEROTH, KARL A

 

STANFORD UNIVERSITY

 

NIH Director's Pioneer Award

 

HARBURY, PEHR A

 

STANFORD UNIVERSITY SCHOOL OF MEDICINE

 

NIH Director's Pioneer Award

 

JARVIS, ERICH D

 

DUKE UNIVERSITY MEDICAL CENTER

 

NIH Director's Pioneer Award

 

RANDO, THOMAS A

 

STANFORD UNIVERSITY SCHOOL OF MEDICINE

 

NIH Director's Pioneer Award

 

SMITH, DEREK J

 

UNIVERSITY OF CAMBRIDGE

 

NIH Director's Pioneer Award

 

TONONI, GIULIO

 

UNIVERSITY OF WISCONSIN - MADISON MEDICAL SCHOOL

 

NIH Director's Pioneer Award

 

WATERMAN-STORER, CLARE M.

 

SCRIPPS RESEARCH INSTITUTE

 

NIH Director's Pioneer Award

 

WOLFE, NATHAN

 

JOHNS HOPKINS UNIVERSITY

 

NIH Director's Pioneer Award

 

YUAN, JUNYING

 

HARVARD MEDICAL SCHOOL

 

NIH Director's Pioneer Award

 

 

2004 NIH Director's Pioneer Award (DP1) - RFA-RM-04-500

PI Name Institution Name Title
ABBOTT, LARRY F.

 

BRANDEIS UNIVERSITY

 

NIH Director's Pioneer Award

 

DALEY, GEORGE Q

 

CHILDREN'S HOSPITAL (BOSTON)

 

NIH Director's Pioneer Award

 

HELLINGA, HOMME W.

 

DUKE UNIVERSITY

 

NIH Director's Pioneer Award

 

MCCUNE, JOSEPH M

 

J. DAVID GLADSTONE INSTITUTES

 

NIH Director's Pioneer Award

 

MCKNIGHT, STEVEN L

 

UNIVERSITY OF TEXAS SW MED CTR/DALLAS

 

NIH Director's Pioneer Award

 

MIRKIN, CHAD A

 

NORTHWESTERN UNIVERSITY

 

NIH Director's Pioneer Award

 

PHILLIPS, ROB

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

NIH Director's Pioneer Award

 

QUAKE, STEPHEN R

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

NIH Director's Pioneer Award

 

XIE, SUNNEY

 

HARVARD UNIVERSITY

 

NIH Director's Pioneer Award

 

This page last reviewed on October 4, 2022