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Funded Research

NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed) PA-21-151
PI NameInstitution NameTitle
KASHANCHI, FATAHGEORGE MASON UNIVERSITYAmerican Society for Intercellular Communication (ASIC)

 

Advancing Extracellular RNA (exRNA) Communication Research: Single Extracellular Vesicle (EV) Sorting, Isolation, and Analysis of Cargo (UG3/UH3 Clinical Trial Not Allowed) RFA-RM-18-028 In September 2021, the awards below transitioned into their UH3 phase. The UG3 phase (first phase) of these awards focused on technology development and feasibility, while the UG3 phase will focus on demonstrating isolation effectiveness using human biofluids.
PI NameInstitution NameTitle
CHIU, DANIEL TUNIVERSITY OF WASHINGTONSingle Extracellular Vesicle Sorting and Analysis
DAS, SAUMYA (contact)
TALISMAN, TIJANA
VAN KEUREN-JENSEN, KENDALL
MASSACHUSETTS GENERAL HOSPITALMolecular dissection and imaging of extracellular vesicles to define their origin and targets
GHIRAN, IONITA CALIN (contact)
JONES, JENNIFER
MILOSAVLJEVIC, ALEKSANDAR
BETH ISRAEL DEACONESS MEDICAL CENTERIntegrative, multi-parametric characterization of the EV surface protein and nucleic acid landscape by nano-flow and sorting cytometry
REATEGUI, EDUARDO (contact)
KIM, YON SON BETTY
OHIO STATE UNIVERSITYMicrofluidics Array Based Sorting, Isolation, and RNA Analysis in Single Extracellular V csicles
ROUTENBERG, DAVID AARONMESO SCALE DIAGNOSTICS, LLCEnabling isolation and characterization of single extracellular vesicles and their molecular contents using multi-marker surface signatures
WONG, DAVID T (contact)
HUANG, TONY JUN
KIM, SUNG
KIM, YONG
XIE, YA-HONG
UNIVERSITY OF CALIFORNIA LOS ANGELESAcoustofluidic Separation (AFS), Purification and Raman Spectral Fingerprinting of Single EVs: From Cell of Origin to Target Cell and Biofluids

 

Advancing Extracellular RNA (exRNA) Communication Research: Improved Isolation and Analysis of exRNA-Carrier Subclasses (UG3/UH3 Clinical Trial Not Allowed) RFA-RM-18-027 In September 2021, the awards below transitioned into their UH3 phase. The UG3 phase (first phase) of these awards focused on technology development and feasibility, while the UG3 phase will focus on UH3 optimizing, refining, and scaling-up of validated separation technologies using human biofluids.
PI NameInstitution NameTitle
CHANG, HSUEH-CHIAUNIVERSITY OF NOTRE DAMEHigh-Throughput Electrokinetic Fractionation and Analysis of Extracellular RNA Nano-Carriers
COFFEY, ROBERT J. (contact)
CHAREST, ALAIN 
VANDERBILT UNIVERSITY MEDICAL CENTERUncovering exRNA and protein determinants of secreted vesicle heterogeneity by flow cytometric purification of vesicle subsets from cells and plasma
LAURENT, LOUISE CHANGUNIVERSITY OF CALIFORNIA, SAN DIEGODevelopment and application of a scalable workflow for immunomagnetic separation of exRNA carrier subclasses and molecular analysis of their cargo
RAFFAI, ROBERT (contact)
MATEESCU, BOGDAN
VAN KEUREN-JENSEN, KENDALL
NORTHERN CALIFORNIA INSTITUTE/RES/EDUP.R.I.S.M: Purification of exRNA by Immuno-capture and Sorting using Microfluidic
WITWER, KENNETH WJOHNS HOPKINS UNIVERSITYNovel Separation Methods for exRNA Carriers: Extracellular Vesicles, Lipoprotein Particles, and Protein Aggregates

 

Data Management and Resource Repository (DMRR) on Extracellular RNA (U54 Clinical Trial Not Allowed) RFA-RM-18-026
PI NameInstitution NameTitle
MILOSAVLJEVIC, ALEKSANDAR (contact)
GALAS, DAVID J.
GERSTEIN, MARK BENDER
BAYLOR COLLEGE OF MEDICINEDATA MANAGEMENT AND RESOURCE REPOSITORY FOR THE EXRNA ATLAS PHASE II

 

NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed) PA-18-648
PI NameInstitution NameTitle
HERMANN, THOMAS CUNIVERSITY OF CALIFORNIA, SAN DIEGO2019 RNA Nanotechnology GRC/GRS

 

Clinical Utility of Extracellular RNA for Biomarker Development (UH2/UH3) RFA-RM-12-013
In 2015, the awards below transitioned into their UH3 phase. The UH2 phase (first phase) of these awards focused on discovery and feasibility, while the UH3 phase will focus on testing and validation of the biomarkers.
PI NameInstitution NameTitle
CARTER, BOB S (contact)
HOCHBERG, FRED H
UNIVERSITY OF CALIFORNIA SAN DIEGOexRNA Biomarkers for Human Glioma
DAS, SAUMYA (contact)
KWONG, RAYMOND Y
ROSENZWEIG, ANTHONY 
SABATINE, MARC S
BETH ISRAEL DEACONESS MEDICAL CENTERPlasma miRNA predictors of adverse mechanical and electrical remodeling after MI
FREEDMAN, JANE EUNIV OF MASSACHUSETTS MED SCH WORCESTERExtracellular RNAs: Biomarkers for Cardiovascular Risk and Disease
JENSEN, KENDALL(contact)
ADELSON, P. DAVID
HUENTELMAN, MATTHEW
KALANI, YASHAR
TRANSLATIONAL GENOMICS RESEARCH INSTexRNA signatures Predict Outcomes after brain injury
LAURENT, LOUISE CUNIVERSITY OF CALIFORNIA SAN DIEGOExRNAs for Early Identification of Pregnancies at Risk for Placental Dysfunction
PATEL, TUSHARMAYO CLINIC JACKSONVILLEExtracellular non-coding RNA biomarkers of hepatocellular cancer
SAUGSTAD, JULIE ANNE (contact)
QUINN, JOSEPH F
OREGON HEALTH AND SCI UNIVERSITYClinical Utility of MicroRNAs as Diagnostic Biomarkers of Alzheimers Disease
TUSCHL, THOMAS (contact)
SUTHANTHIRAN, MANIKKAM
ROCKEFELLER UNIVERSITYClinical utility of extracellular RNA as marker of kidney disease progression
WEINER, HOWARD LBRIGHAM AND WOMEN'S HOSPITALCirculating MicroRNAs as Disease Biomarkers in Multiple Sclerosis
WONG, DAVID TUNIVERSITY OF CALIFORNIA LOS ANGELESClinical Utility of Salivary ExRNA Biomarkers for Gastric Cancer Detection

 

Clinical Utility of Extracellular RNA for Therapy Development (UH2/UH3) RFA-RM-12-014In August 2015, the awards below transitioned into their UH3 phase. The UH2 phase (first phase) of these awards focused on discovery and feasibility, while the UH3 phase will focus on testing and validation of the therapeutics.
PI NameInstitution NameTitle
ABDEL-MAGEED, ASIM, BTULANE UNIVERSITY OF LOUISIANATargeting Tumor-Derived exRNA-Containing Microvesicles by High Throughput Screeni
ARONIN, NEILUNIV OF MASSACHUSETTS MED SCH WORCESTERExosome based therapeutics in Huntingtons disease
KRAIG, RICHARD PUNIVERSITY OF CHICAGOExosome RNA-Therapeutics to Promote CNS Myelination
MATIN, ACSTANFORD UNIVERSITYHER2-targeted exosomal delivery of therapeutic mRNA for enzyme pro-drug therapy
QUESENBERRY, PETER JRHODE ISLAND HOSPITALRegulation of renal and bone marrow injury by extracellular vesicle non-coding RN
SCHMITTGEN, THOMAS D (contact)
PHELPS, MITCH A
UNIVERSITY OF FLORIDATargeted delivery of microRNA-loaded microvesicle for cancer therapy
SOOD, ANIL K (contact)
CALIN, GEORGE A
LOPEZ-BERESTEIN, GABRIEL
UT MD ANDERSON CANCER CTRNovel extra cellular RNA-based combinatorial RNA inhibition therapy
ZHANG, HUANG-GE (contact)
GUO, PEIXUAN
UNIVERSITY OF LOUISVILLEFruit exosome-like particles for therapeutic delivery of extracellular miRNAs

 

NIH Support for Conferences and Scientific Meetings (Parent R13/U13) PA-13-347
PI NameInstitution NameTitle
GUO, PEIXUANGORDON RESEARCH CONFERENCES2015 RNA Nanotechnology Gordon Research Conference
QUESENBERRY, PETER JGORDON RESEARCH CONFERENCES2016 Extracellular Vesicles Gordon Research Conference
WITWER, KENNETH WJOHNS HOPKINS UNIVERSITYInternational Society for Extracellular Vesicles - Education Day & Meeting
WOODLAND, DAVID L.KEYSTONE CONFERENCE CENTERExosomes/Microvesicles: Novel Mechanisms of Cell-Cell Communication

 

Defining A Comprehensive Reference Profile of Circulating Human Extracellular RNA (U01) RFA-RM-13-014
PI NameInstitution NameTitle
FREEDMAN, JANE E (contact)
GERSTEIN, MARK BENDER
MUKAMAL, KENNETH JAY
ODONNELL, CHRISTOPHER J
UNIV OF MASSACHUSETTS MED SCH WORCESTERRacial and Ethnic Diversity in Human Extracellular RNA
GALAS, DAVID J. (contact)
NICKERSON, DEBORAH A
WANG, KAI
PACIFIC NORTHWEST RESEARCH INSTITUTEReference Profiles of Extracellular RNA in 4 Body Fluids of Healthy Humans
GHIRAN, IONITA CALINBETH ISRAEL DEACONESS MEDICAL CENTERImpact of circadian rhythm in obtaining reference profiles of exRNAs in healthy in healthy individuals
LAURENT, LOUISE CUNIVERSITY OF CALIFORNIA SAN DIEGOReference Profiles of ExRNAs in Normal Human Pregnancy
TEWARI, MUNEESHUNIVERSITY OF MICHIGAN AT ANN ARBORReference Profiles of ExRNA in Biofluids from Well-Defined Human Cohorts
WOODRUFF, PRESCOTT G (contact)
ERLE, DAVID J
UNIVERSITY OF CALIFORNIA, SAN FRANCISCODefining A Comprehensive Reference Profile of Circulating Human Extracellular RNA

 

Data Management and Resource Repository (DMRR) on Extracellular RNA (U54) RFA-RM-12-010
PI NameInstitution NameTitle
MILOSAVLJEVIC, ALEKSANDAR (contact)
GALAS, DAVID J.
GERSTEIN, MARK BENDER
BAYLOR COLLEGE OF MEDICINEData management and Resource Repository for the exRNA Atlas

 

Extracellular RNA Biogenesis, Biodistribution, Uptake, and Effector Function (U19) RFA-RM-12-012
PI NameInstitution NameTitle
BLELLOCH, ROBERT HUNIVERSITY OF CALIFORNIA-SAN FRANCISCOIn Vivo Regulated Release and Function of Extracellular Small RNAs
BREAKEFIELD, XANDRA OWENS (contact)
CHAREST, ALAIN 
GOULD, STEPHEN J
KRICHEVSKY, ANNA M.
MEMPEL, THORSTEN ROMAN
MASSACHUSETTS GENERAL HOSPexRNA released by glioblastoma alters brain microenvironment
COFFEY, ROBERT J.VANDERBILT UNIVERSITY MED CTRSecreted RNA during CRC progression biogenesis function and clinical markers
MCMANUS, MICHAEL TUNIVERSITY OF CALIFORNIA-SAN FRANCISCOGenetic models for exRNA communication
TUSCHL, THOMASROCKEFELLER UNIVERSITYDefinition of Serum Ribonucleoprotein Composition and its Regulation and Function

 

This page last reviewed on January 23, 2024