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Title Authors Journal PubMedID Publication Date
The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis. Gestaut, Daniel; Roh, Soung Hun; Ma, Boxue; Pintilie, Grigore; Joachimiak, Lukasz A; Leitner, Alexander; Walzthoeni, Thomas; Aebersold, Ruedi; Chiu, Wah; Frydman, Judith Cell. 30955883 2019 Apr 18;
Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement. Patel, Avinash B; Moore, Camille M; Greber, Basil J; Luo, Jie; Zukin, Stefan A; Ranish, Jeff; Nogales, Eva eLife 31886770 2019 12 30
Structure of the human cation-chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy. Yang, Xiaoyong; Wang, Qinzhe; Cao, Erhu Nature communications. 32081947 2020 Feb 21;
Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins. Rahman, Md Mahfuzur; Teng, Jinfeng; Worrell, Brady T; Noviello, Colleen M; Lee, Myeongseon; Karlin, Arthur; Stowell, Michael H B; Hibbs, Ryan E Neuron. 32275860 2020 06 17;
Molecular dysregulation of ciliary polycystin-2 channels caused by variants in the TOP domain. Vien, Thuy N; Wang, Jinliang; Ng, Leo C T; Cao, Erhu; DeCaen, Paul G Proceedings of the National Academy of Sciences of the United States of America. 32332171 2020 May 12;
Deconvoluting Lipid Nanoparticle Structure for Messenger RNA Delivery. Eygeris, Yulia; Patel, Siddharth; Jozic, Antony; Sahay, Gaurav Nano letters. 32375002 2020 06 10;
Cryo-EM structures provide insight into how E. coli F1Fo ATP synthase accommodates symmetry mismatch. Sobti, Meghna; Walshe, James L; Wu, Di; Ishmukhametov, Robert; Zeng, Yi C; Robinson, Carol V; Berry, Richard M; Stewart, Alastair G Nature communications. 32457314 2020 May 26;
Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel. Zheng, Xiangdong; Fu, Ziao; Su, Deyuan; Zhang, Yuebin; Li, Minghui; Pan, Yaping; Li, Huan; Li, Shufang; Grassucci, Robert A; Ren, Zhenning; Hu, Zhengshan; Li, Xueming; Zhou, Ming; Li, Guohui; Frank, Joachim; Yang, Jian Nature structural & molecular biology. 32483338 2020 07;
The His-Gly motif of acid-sensing ion channels resides in a reentrant 'loop' implicated in gating and ion selectivity. Yoder, Nate; Gouaux, Eric eLife 32496192 2020 06 04
Controlling the SARS-CoV-2 Spike Glycoprotein Conformation. Henderson, Rory; Edwards, Robert J; Mansouri, Katayoun; Janowska, Katarzyna; Stalls, Victoria; Gobeil, Sophie; Kopp, Megan; Hsu, Allen; Borgnia, Mario; Parks, Rob; Haynes, Barton F; Acharya, Priyamvada bioRxiv : the preprint server for biology. 32511343 2020 May 18;
Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis. Herrera, Natalia G; Morano, Nicholas C; Celikgil, Alev; Georgiev, George I; Malonis, Ryan J; Lee, James H; Tong, Karen; Vergnolle, Olivia; Massimi, Aldo B; Yen, Laura Y; Noble, Alex J; Kopylov, Mykhailo; Bonanno, Jeffrey B; Garrett-Thomson, Sarah C; Hayes, David B; Bortz 3rd, Robert H; Wirchnianski, Ariel S; Florez, Catalina; Laudermilch, Ethan; Haslwanter, Denise; Fels, J Maximilian; Dieterle, M Eugenia; Jangra, Rohit K; Barnhill, Jason; Mengotto, Amanda; Kimmel, Duncan; Daily, Johanna P; Pirofski, Liise-Anne; Chandran, Kartik; Brenowitz, Michael; Garforth, Scott J; Eng, Edward T; Lai, Jonathan R; Almo, Steven C bioRxiv : the preprint server for biology 32587972 2020 Jun 17
Chemical and structural investigation of the paroxetine-human serotonin transporter complex. Coleman, Jonathan A; Navratna, Vikas; Antermite, Daniele; Yang, Dongxue; Bull, James A; Gouaux, Eric eLife. 32618269 2020 Jul 03;
Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex. Chen, James; Malone, Brandon; Llewellyn, Eliza; Grasso, Michael; Shelton, Patrick M M; Olinares, Paul Dominic B; Maruthi, Kashyap; Eng, Ed; Vatandaslar, Hasan; Chait, Brian T; Kapoor, Tarun; Darst, Seth A; Campbell, Elizabeth A bioRxiv : the preprint server for biology. 32676607 2020 Jul 13;
Subdomain cryo-EM structure of nodaviral replication protein A crown complex provides mechanistic insights into RNA genome replication. Unchwaniwala, Nuruddin; Zhan, Hong; Pennington, Janice; Horswill, Mark; den Boon, Johan A; Ahlquist, Paul Proceedings of the National Academy of Sciences of the United States of America. 32690711 2020 08 04;
Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike. Liu, Lihong; Wang, Pengfei; Nair, Manoj S; Yu, Jian; Rapp, Micah; Wang, Qian; Luo, Yang; Chan, Jasper F-W; Sahi, Vincent; Figueroa, Amir; Guo, Xinzheng V; Cerutti, Gabriele; Bimela, Jude; Gorman, Jason; Zhou, Tongqing; Chen, Zhiwei; Yuen, Kwok-Yung; Kwong Nature. 32698192 2020 08;
Controlling the SARS-CoV-2 spike glycoprotein conformation. Henderson, Rory; Edwards, Robert J; Mansouri, Katayoun; Janowska, Katarzyna; Stalls, Victoria; Gobeil, Sophie M C; Kopp, Megan; Li, Dapeng; Parks, Rob; Hsu, Allen L; Borgnia, Mario J; Haynes, Barton F; Acharya, Priyamvada Nature structural & molecular biology. 32699321 2020 10;
Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments. Doran, Matthew H; Pavadai, Elumalai; Rynkiewicz, Michael J; Walklate, Jonathan; Bullitt, Esther; Moore, Jeffrey R; Regnier, Michael; Geeves, Michael A; Lehman, William Biophysical journal. 32730789 2020 Aug 18;
Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex. Chen, James; Malone, Brandon; Llewellyn, Eliza; Grasso, Michael; Shelton, Patrick M M; Olinares, Paul Dominic B; Maruthi, Kashyap; Eng, Edward T; Vatandaslar, Hasan; Chait, Brian T; Kapoor, Tarun M; Darst, Seth A; Campbell, Elizabeth A Cell. 32783916 2020 09 17;
Structural basis of transcription-translation coupling. Wang, Chengyuan; Molodtsov, Vadim; Firlar, Emre; Kaelber, Jason T; Blaha, Gregor; Su, Min; Ebright, Richard H Science (New York, N.Y.) 32820061 2020 09 11
Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9?Å. Flores, Jonathan A; Haddad, Bassam G; Dolan, Kimberly A; Myers, Janette B; Yoshioka, Craig C; Copperman, Jeremy; Zuckerman, Daniel M; Reichow, Steve L Nature communications. 32859914 2020 08 28;
Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9. Fromm, Simon A; Lawrence, Rosalie E; Hurley, James H Nature structural & molecular biology. 32868926 2020 Nov;
Structural analysis of the Legionella pneumophila Dot/Icm type IV secretion system core complex. Durie, Clarissa L; Sheedlo, Michael J; Chung, Jeong Min; Byrne, Brenda G; Su, Min; Knight, Thomas; Swanson, Michele; Lacy, D Borden; Ohi, Melanie D eLife. 32876045 2020 Sep 02;
Shared structural mechanisms of general anaesthetics and benzodiazepines. Kim, Jeong Joo; Gharpure, Anant; Teng, Jinfeng; Zhuang, Yuxuan; Howard, Rebecca J; Zhu, Shaotong; Noviello, Colleen M; Walsh Jr, Richard M; Lindahl, Erik; Hibbs, Ryan E Nature 32879488 2020 09
Light-coupled cryo-plunger for time-resolved cryo-EM. Yoder, Nate; Jalali-Yazdi, Farzad; Noreng, Sigrid; Houser, Alexandra; Baconguis, Isabelle; Gouaux, Eric Journal of structural biology. 32950604 2020 Sep 17;
Synthetic group A streptogramin antibiotics that overcome Vat resistance. Li, Qi; Pellegrino, Jenna; Lee, D John; Tran, Arthur A; Chaires, Hector A; Wang, Ruoxi; Park, Jesslyn E; Ji, Kaijie; Chow, David; Zhang, Na; Brilot, Axel F; Biel, Justin T; van Zundert, Gydo; Borrelli, Kenneth; Shinabarger, Dean; Wolfe, Cindy; Murray, Beverly; Jacobson, Matthew P; Mühle, Estelle; Chesneau, Olivier; Fraser, James S; Seiple, Ian B Nature 32968273 2020 10
Adeno-Associated Virus (AAV-DJ)-Cryo-EM Structure at 1.56 Å Resolution. Xie, Qing; Yoshioka, Craig K; Chapman, Michael S Viruses 33092282 2020 10 20
A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel. Liu, Chang; Reese, Rebecca; Vu, Simon; Rougé, Lionel; Shields, Shannon D; Kakiuchi-Kiyota, Satoko; Chen, Huifen; Johnson, Kevin; Shi, Yu Patrick; Chernov-Rogan, Tania; Greiner, Demi Maria Zabala; Kohli, Pawan Bir; Hackos, David; Brillantes, Bobby; Tam, Christine; Li, Tianbo; Wang, Jianyong; Safina, Brian; Magnuson, Steve; Volgraf, Matthew; Payandeh, Jian; Zheng, Jie; Rohou, Alexis; Chen, Jun Neuron 33152265 2021 01 20
Structural Basis for Virulence Activation of Francisella tularensis. Travis, Brady A; Ramsey, Kathryn M; Prezioso, Samantha M; Tallo, Thomas; Wandzilak, Jamie M; Hsu, Allen; Borgnia, Mario; Bartesaghi, Alberto; Dove, Simon L; Brennan, Richard G; Schumacher, Maria A Molecular cell 33217319 2021 01 07
Native Mass Spectrometry-Based Screening for Optimal Sample Preparation in Single-Particle Cryo-EM. Olinares, Paul Dominic B; Kang, Jin Young; Llewellyn, Eliza; Chiu, Courtney; Chen, James; Malone, Brandon; Saecker, Ruth M; Campbell, Elizabeth A; Darst, Seth A; Chait, Brian T Structure (London, England : 1993) 33217329 2021 02 04
The Structure of an AAV5-AAVR Complex at 2.5 Å Resolution: Implications for Cellular Entry and Immune Neutralization of AAV Gene Therapy Vectors. Silveria, Mark A; Large, Edward E; Zane, Grant M; White, Tommi A; Chapman, Michael S Viruses 33218165 2020 11 18
The Cryo-EM structure of AAV2 Rep68 in complex with ssDNA reveals a malleable AAA+ machine that can switch between oligomeric states. Santosh, Vishaka; Musayev, Faik N; Jaiswal, Rahul; Zárate-Pérez, Francisco; Vandewinkel, Bram; Dierckx, Caroline; Endicott, Molly; Sharifi, Kamyar; Dryden, Kelly; Henckaerts, Els; Escalante, Carlos R Nucleic acids research 33270897 2020 12 16
Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Zhou, Tongqing; Tsybovsky, Yaroslav; Gorman, Jason; Rapp, Micah; Cerutti, Gabriele; Chuang, Gwo-Yu; Katsamba, Phinikoula S; Sampson, Jared M; Schön, Arne; Bimela, Jude; Boyington, Jeffrey C; Nazzari, Alexandra; Olia, Adam S; Shi, Wei; Sastry, Mallika; Stephens, Tyler; Stuckey, Jonathan; Teng, I-Ting; Wang, Pengfei; Wang, Shuishu; Zhang, Baoshan; Friesner, Richard A; Ho, David D; Mascola, John R; Shapiro, Lawrence; Kwong, Peter D Cell host & microbe. 33271067 2020 12 09;
Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases. Kato, Kazuki; Ahmad, Sadeem; Zhu, Zixiang; Young, Janet M; Mu, Xin; Park, Sehoon; Malik, Harmit S; Hur, Sun Molecular cell 33373584 2021 02 04
D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction. Gobeil, Sophie M-C; Janowska, Katarzyna; McDowell, Shana; Mansouri, Katayoun; Parks, Robert; Manne, Kartik; Stalls, Victoria; Kopp, Megan F; Henderson, Rory; Edwards, Robert J; Haynes, Barton F; Acharya, Priyamvada Cell reports 33417835 2021 01 12
Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. Robert Hollingsworth, L; David, Liron; Li, Yang; Griswold, Andrew R; Ruan, Jianbin; Sharif, Humayun; Fontana, Pietro; Orth-He, Elizabeth L; Fu, Tian-Min; Bachovchin, Daniel A; Wu, Hao Nature communications 33420033 2021 01 08
The Cryogenic Electron Microscopy Structure of the Cell Adhesion Regulator Metavinculin Reveals an Isoform-Specific Kinked Helix in Its Cytoskeleton Binding Domain. Rangarajan, Erumbi S; Izard, Tina International journal of molecular sciences 33440717 2021 Jan 11
Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis. Herrera, Natalia G; Morano, Nicholas C; Celikgil, Alev; Georgiev, George I; Malonis, Ryan J; Lee, James H; Tong, Karen; Vergnolle, Olivia; Massimi, Aldo B; Yen, Laura Y; Noble, Alex J; Kopylov, Mykhailo; Bonanno, Jeffrey B; Garrett-Thomson, Sarah C; Hayes, David B; Bortz 3rd, Robert H; Wirchnianski, Ariel S; Florez, Catalina; Laudermilch, Ethan; Haslwanter, Denise; Fels, J Maximilian; Dieterle, M Eugenia; Jangra, Rohit K; Barnhill, Jason; Mengotto, Amanda; Kimmel, Duncan; Daily, Johanna P; Pirofski, Liise-Anne; Chandran, Kartik; Brenowitz, Michael; Garforth, Scott J; Eng, Edward T; Lai, Jonathan R; Almo, Steven C ACS omega 33458462 2021 Jan 12
Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction. Grau, Daniel; Zhang, Yixiao; Lee, Chul-Hwan; Valencia-Sánchez, Marco; Zhang, Jenny; Wang, Miao; Holder, Marlene; Svetlov, Vladimir; Tan, Dongyan; Nudler, Evgeny; Reinberg, Danny; Walz, Thomas; Armache, Karim-Jean Nature communications 33514705 2021 01 29
Illuminating endosomal escape of polymorphic lipid nanoparticles that boost mRNA delivery. Herrera, Marco; Kim, Jeonghwan; Eygeris, Yulia; Jozic, Antony; Sahay, Gaurav Biomaterials science 33586742 2021 Jun 15
Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses. Feldman, Jared; Bals, Julia; Altomare, Clara G; St Denis, Kerri; Lam, Evan C; Hauser, Blake M; Ronsard, Larance; Sangesland, Maya; Moreno, Thalia Bracamonte; Okonkwo, Vintus; Hartojo, Nathania; Balazs, Alejandro B; Bajic, Goran; Lingwood, Daniel; Schmidt, Aaron G bioRxiv : the preprint server for biology 33594359 2021 Jul 09
CorRelator: Interactive software for real-time high precision cryo-correlative light and electron microscopy. Yang, Jie E; Larson, Matthew R; Sibert, Bryan S; Shrum, Samantha; Wright, Elizabeth R Journal of structural biology 33610654 2021 Feb 18
Structure of the human Mediator-bound transcription preinitiation complex. Abdella, R; Talyzina, A; Chen, S; Inouye, C J; Tjian, R; He, Y Science (New York, N.Y.) 33707221 2021 04 02
Molecular assemblies of the catalytic domain of SOS with KRas and oncogenic mutants. Moghadamchargari, Zahra; Shirzadeh, Mehdi; Liu, Chang; Schrecke, Samantha; Packianathan, Charles; Russell, David H; Zhao, Minglei; Laganowsky, Arthur Proceedings of the National Academy of Sciences of the United States of America 33723061 2021 Mar 23
DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation. Hollingsworth, L Robert; Sharif, Humayun; Griswold, Andrew R; Fontana, Pietro; Mintseris, Julian; Dagbay, Kevin B; Paulo, Joao A; Gygi, Steven P; Bachovchin, Daniel A; Wu, Hao Nature 33731932 2021 Apr
Structure and gating mechanism of the α7 nicotinic acetylcholine receptor. Noviello, Colleen M; Gharpure, Anant; Mukhtasimova, Nuriya; Cabuco, Rico; Baxter, Leah; Borek, Dominika; Sine, Steven M; Hibbs, Ryan E Cell 33735609 2021 Apr 15
Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes. Sun, Dapeng; Sang, Zhe; Kim, Yong Joon; Xiang, Yufei; Cohen, Tomer; Belford, Anna K; Huet, Alexis; Conway, James F; Sun, Ji; Taylor, Derek J; Schneidman-Duhovny, Dina; Zhang, Cheng; Huang, Wei; Shi, Yi bioRxiv : the preprint server for biology 33758850 2021 Mar 10
Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex. Malone, Brandon; Chen, James; Wang, Qi; Llewellyn, Eliza; Choi, Young Joo; Olinares, Paul Dominic B; Cao, Xinyun; Hernandez, Carolina; Eng, Edward T; Chait, Brian T; Shaw, David E; Landick, Robert; Darst, Seth A; Campbell, Elizabeth A bioRxiv : the preprint server for biology 33758867 2021 Mar 14
Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation. Jette, Claudia A; Barnes, Christopher O; Kirk, Sharon M; Melillo, Bruno; Smith 3rd, Amos B; Bjorkman, Pamela J Nature communications 33782388 2021 03 29
Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite. Cerutti, Gabriele; Guo, Yicheng; Zhou, Tongqing; Gorman, Jason; Lee, Myungjin; Rapp, Micah; Reddem, Eswar R; Yu, Jian; Bahna, Fabiana; Bimela, Jude; Huang, Yaoxing; Katsamba, Phinikoula S; Liu, Lihong; Nair, Manoj S; Rawi, Reda; Olia, Adam S; Wang, Pengfei; Zhang, Baoshan; Chuang, Gwo-Yu; Ho, David D; Sheng, Zizhang; Kwong, Peter D; Shapiro, Lawrence Cell host & microbe 33789084 2021 05 12
Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class. Rapp, Micah; Guo, Yicheng; Reddem, Eswar R; Yu, Jian; Liu, Lihong; Wang, Pengfei; Cerutti, Gabriele; Katsamba, Phinikoula; Bimela, Jude S; Bahna, Fabiana A; Mannepalli, Seetha M; Zhang, Baoshan; Kwong, Peter D; Huang, Yaoxing; Ho, David D; Shapiro, Lawrence; Sheng, Zizhang Cell reports 33794145 2021 04 06
Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM. Shen, Betty W; Quispe, Joel D; Luyten, Yvette; McGough, Benjamin E; Morgan, Richard D; Stoddard, Barry L Structure (London, England : 1993) 33826880 2021 Jun 03
Extracellular cap domain is an essential component of the TRPV1 gating mechanism. Nadezhdin, Kirill D; Neuberger, Arthur; Nikolaev, Yury A; Murphy, Lyle A; Gracheva, Elena O; Bagriantsev, Sviatoslav N; Sobolevsky, Alexander I Nature communications 33846324 2021 04 12
Structural basis of long-range to short-range synaptic transition in NHEJ. Chen, Siyu; Lee, Linda; Naila, Tasmin; Fishbain, Susan; Wang, Annie; Tomkinson, Alan E; Lees-Miller, Susan P; He, Yuan Nature 33854234 2021 May
Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex. Malone, Brandon; Chen, James; Wang, Qi; Llewellyn, Eliza; Choi, Young Joo; Olinares, Paul Dominic B; Cao, Xinyun; Hernandez, Carolina; Eng, Edward T; Chait, Brian T; Shaw, David E; Landick, Robert; Darst, Seth A; Campbell, Elizabeth A Proceedings of the National Academy of Sciences of the United States of America 33883267 2021 05 11
Cryo-EM structure of a thermostable bacterial nanocompartment. Wiryaman, Timothy; Toor, Navtej IUCrJ 33953921 2021 May 01
Structures of telomerase at several steps of telomere repeat synthesis. He, Yao; Wang, Yaqiang; Liu, Baocheng; Helmling, Christina; Sušac, Lukas; Cheng, Ryan; Zhou, Z Hong; Feigon, Juli Nature 33981033 2021 05
Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition. Yu, Jie; Rao, Prashant; Clark, Sarah; Mitra, Jaba; Ha, Taekjip; Gouaux, Eric Nature 33981040 2021 Jun
Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies. Williams, Wilton B; Meyerhoff, R Ryan; Edwards, R J; Li, Hui; Manne, Kartik; Nicely, Nathan I; Henderson, Rory; Zhou, Ye; Janowska, Katarzyna; Mansouri, Katayoun; Gobeil, Sophie; Evangelous, Tyler; Hora, Bhavna; Berry, Madison; Abuahmad, A Yousef; Sprenz, Jordan; Deyton, Margaret; Stalls, Victoria; Kopp, Megan; Hsu, Allen L; Borgnia, Mario J; Stewart-Jones, Guillaume B E; Lee, Matthew S; Bronkema, Naomi; Moody, M Anthony; Wiehe, Kevin; Bradley, Todd; Alam, S Munir; Parks, Robert J; Foulger, Andrew; Oguin, Thomas; Sempowski, Gregory D; Bonsignori, Mattia; LaBranche, Celia C; Montefiori, David C; Seaman, Michael; Santra, Sampa; Perfect, John; Francica, Joseph R; Lynn, Geoffrey M; Aussedat, Baptiste; Walkowicz, William E; Laga, Richard; Kelsoe, Garnett; Saunders, Kevin O; Fera, Daniela; Kwong, Peter D; Seder, Robert A; Bartesaghi, Alberto; Shaw, George M; Acharya, Priyamvada; Haynes, Barton F Cell 34019795 2021 05 27
Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment. Sharif, Humayun; Hollingsworth, L Robert; Griswold, Andrew R; Hsiao, Jeffrey C; Wang, Qinghui; Bachovchin, Daniel A; Wu, Hao Immunity 34019797 2021 07 13
TRPV3 expression and purification for structure determination by Cryo-EM. Neuberger, Arthur; Nadezhdin, Kirill D; Sobolevsky, Alexander I Methods in enzymology 34059288 2021
Structure and function at the lipid-protein interface of a pentameric ligand-gated ion channel. Kumar, Pramod; Cymes, Gisela D; Grosman, Claudio Proceedings of the National Academy of Sciences of the United States of America 34083441 2021 06 08
Production and purification of ATP-sensitive potassium channel particles for cryo-electron microscopy. Driggers, Camden M; Shyng, Show-Ling Methods in enzymology 34099169 2021
Cryo-EM structure of TFIIH/Rad4-Rad23-Rad33 in damaged DNA opening in nucleotide excision repair. van Eeuwen, Trevor; Shim, Yoonjung; Kim, Hee Jong; Zhao, Tingting; Basu, Shrabani; Garcia, Benjamin A; Kaplan, Craig D; Min, Jung-Hyun; Murakami, Kenji Nature communications 34099686 2021 06 07
Structural insight on assembly-line catalysis in terpene biosynthesis. Faylo, Jacque L; van Eeuwen, Trevor; Kim, Hee Jong; Gorbea Colón, Jose J; Garcia, Benjamin A; Murakami, Kenji; Christianson, David W Nature communications 34108468 2021 06 09
Structural basis for accommodation of emerging B.1.351 and B.1.1.7 variants by two potent SARS-CoV-2 neutralizing antibodies. Cerutti, Gabriele; Rapp, Micah; Guo, Yicheng; Bahna, Fabiana; Bimela, Jude; Reddem, Eswar R; Yu, Jian; Wang, Pengfei; Liu, Lihong; Huang, Yaoxing; Ho, David D; Kwong, Peter D; Sheng, Zizhang; Shapiro, Lawrence Structure (London, England : 1993) 34111408 2021 07 01
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection. Chen, Peng; Zeng, Ji; Liu, Zheng; Thaker, Hatim; Wang, Siyu; Tian, Songhai; Zhang, Jie; Tao, Liang; Gutierrez, Craig B; Xing, Li; Gerhard, Ralf; Huang, Lan; Dong, Min; Jin, Rongsheng Nature communications 34145250 2021 06 18
Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Gobeil, Sophie M-C; Janowska, Katarzyna; McDowell, Shana; Mansouri, Katayoun; Parks, Robert; Stalls, Victoria; Kopp, Megan F; Manne, Kartik; Li, Dapeng; Wiehe, Kevin; Saunders, Kevin O; Edwards, Robert J; Korber, Bette; Haynes, Barton F; Henderson, Rory; Acharya, Priyamvada Science (New York, N.Y.) 34168071 2021 08 06
Heat-dependent opening of TRPV1 in the presence of capsaicin. Kwon, Do Hoon; Zhang, Feng; Suo, Yang; Bouvette, Jonathan; Borgnia, Mario J; Lee, Seok-Yong Nature structural & molecular biology 34239123 2021 07
Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. Nadezhdin, Kirill D; Neuberger, Arthur; Trofimov, Yuri A; Krylov, Nikolay A; Sinica, Viktor; Kupko, Nikita; Vlachova, Viktorie; Zakharian, Eleonora; Efremov, Roman G; Sobolevsky, Alexander I Nature structural & molecular biology 34239124 2021 07
In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies. Li, Dapeng; Edwards, Robert J; Manne, Kartik; Martinez, David R; Schäfer, Alexandra; Alam, S Munir; Wiehe, Kevin; Lu, Xiaozhi; Parks, Robert; Sutherland, Laura L; Oguin 3rd, Thomas H; McDanal, Charlene; Perez, Lautaro G; Mansouri, Katayoun; Gobeil, Sophie M C; Janowska, Katarzyna; Stalls, Victoria; Kopp, Megan; Cai, Fangping; Lee, Esther; Foulger, Andrew; Hernandez, Giovanna E; Sanzone, Aja; Tilahun, Kedamawit; Jiang, Chuancang; Tse, Longping V; Bock, Kevin W; Minai, Mahnaz; Nagata, Bianca M; Cronin, Kenneth; Gee-Lai, Victoria; Deyton, Margaret; Barr, Maggie; Von Holle, Tarra; Macintyre, Andrew N; Stover, Erica; Feldman, Jared; Hauser, Blake M; Caradonna, Timothy M; Scobey, Trevor D; Rountree, Wes; Wang, Yunfei; Moody, M Anthony; Cain, Derek W; DeMarco, C Todd; Denny, Thomas N; Woods, Christopher W; Petzold, Elizabeth W; Schmidt, Aaron G; Teng, I-Ting; Zhou, Tongqing; Kwong, Peter D; Mascola, John R; Graham, Barney S; Moore, Ian N; Seder, Robert; Andersen, Hanne; Lewis, Mark G; Montefiori, David C; Sempowski, Gregory D; Baric, Ralph S; Acharya, Priyamvada; Haynes, Barton F; Saunders, Kevin O Cell 34242577 2021 08 05
Zinc binding alters the conformational dynamics and drives the transport cycle of the cation diffusion facilitator YiiP. Lopez-Redondo, Maria; Fan, Shujie; Koide, Akiko; Koide, Shohei; Beckstein, Oliver; Stokes, David L The Journal of general physiology 34254979 2021 Aug 02
Structural basis for potassium transport in prokaryotes by KdpFABC. Sweet, Marie E; Larsen, Casper; Zhang, Xihui; Schlame, Michael; Pedersen, Bjørn P; Stokes, David L Proceedings of the National Academy of Sciences of the United States of America 34272288 2021 Jul 20
Structural basis for the structural dynamics of human mitochondrial chaperonin mHsp60. Wang, Joseph Che-Yen; Chen, Lingling Scientific reports 34285302 2021 07 20
Allosteric Inhibition of a Vesicular Glutamate Transporter by an Isoform-Specific Antibody. Eriksen, Jacob; Li, Fei; Stroud, Robert M; Edwards, Robert H Biochemistry 34319067 2021 08 17
Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation. Hu, Qi; Botuyan, Maria Victoria; Zhao, Debiao; Cui, Gaofeng; Mer, Elie; Mer, Georges Nature 34321665 2021 08
Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes. Sun, Dapeng; Sang, Zhe; Kim, Yong Joon; Xiang, Yufei; Cohen, Tomer; Belford, Anna K; Huet, Alexis; Conway, James F; Sun, Ji; Taylor, Derek J; Schneidman-Duhovny, Dina; Zhang, Cheng; Huang, Wei; Shi, Yi Nature communications 34344900 2021 08 03
HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases. Rathinaswamy, Manoj K; Fleming, Kaelin D; Dalwadi, Udit; Pardon, Els; Harris, Noah J; Yip, Calvin K; Steyaert, Jan; Burke, John E Structure (London, England : 1993) 34348129 2021 12 02
Cryo-EM structures of full-length Tetrahymena ribozyme at 3.1 Å resolution. Su, Zhaoming; Zhang, Kaiming; Kappel, Kalli; Li, Shanshan; Palo, Michael Z; Pintilie, Grigore D; Rangan, Ramya; Luo, Bingnan; Wei, Yuquan; Das, Rhiju; Chiu, Wah Nature 34381213 2021 Aug
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Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide. Zhao, Yongxiang; Roy, Kasturi; Vidossich, Pietro; Cancedda, Laura; De Vivo, Marco; Forbush, Biff; Cao, Erhu Nature communications 35585053 2022 05 18
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Architecture of the human erythrocyte ankyrin-1 complex. Vallese, Francesca; Kim, Kookjoo; Yen, Laura Y; Johnston, Jake D; Noble, Alex J; Calì, Tito; Clarke, Oliver Biggs Nature structural & molecular biology 35835865 2022 07
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Structurally derived universal mechanism for the catalytic cycle of the tail-anchored targeting factor Get3. Fry, Michelle Y; Najdrová, Vladimíra; Maggiolo, Ailiena O; Saladi, Shyam M; Doležal, Pavel; Clemons Jr, William M Nature structural & molecular biology 35851188 2022 08
Conformational landscape of the yeast SAGA complex as revealed by cryo-EM. Vasyliuk, Diana; Felt, Joeseph; Zhong, Ellen D; Berger, Bonnie; Davis, Joseph H; Yip, Calvin K Scientific reports 35853968 2022 07 19
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Autoantibody mimicry of hormone action at the thyrotropin receptor. Faust, Bryan; Billesbølle, Christian B; Suomivuori, Carl-Mikael; Singh, Isha; Zhang, Kaihua; Hoppe, Nicholas; Pinto, Antonio F M; Diedrich, Jolene K; Muftuoglu, Yagmur; Szkudlinski, Mariusz W; Saghatelian, Alan; Dror, Ron O; Cheng, Yifan; Manglik, Aashish Nature 35940205 2022 09
Visualization of conformational changes and membrane remodeling leading to genome delivery by viral class-II fusion machinery. Mangala Prasad, Vidya; Blijleven, Jelle S; Smit, Jolanda M; Lee, Kelly K Nature communications 35970990 2022 08 15
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Structural and mechanistic basis for recognition of alternative tRNA precursor substrates by bacterial ribonuclease P. Zhu, Jiaqiang; Huang, Wei; Zhao, Jing; Huynh, Loc; Taylor, Derek J; Harris, Michael E Nature communications 36045135 2022 08 31
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Batch Production of High-Quality Graphene Grids for Cryo-EM: Cryo-EM Structure of Methylococcus capsulatus Soluble Methane Monooxygenase Hydroxylase. Ahn, Eungjin; Kim, Byungchul; Park, Soyoung; Erwin, Amanda L; Sung, Suk Hyun; Hovden, Robert; Mosalaganti, Shyamal; Cho, Uhn-Soo ACS nano 36926824 2023 Mar 28
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Human TRPV1 structure and inhibition by the analgesic SB-366791. Neuberger, Arthur; Oda, Mai; Nikolaev, Yury A; Nadezhdin, Kirill D; Gracheva, Elena O; Bagriantsev, Sviatoslav N; Sobolevsky, Alexander I Nature communications 37117175 2023 Apr 28
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Structural basis for breadth development in the HIV-1 V3-glycan targeting DH270 antibody clonal lineage. Henderson, Rory; Zhou, Ye; Stalls, Victoria; Wiehe, Kevin; Saunders, Kevin O; Wagh, Kshitij; Anasti, Kara; Barr, Maggie; Parks, Robert; Alam, S Munir; Korber, Bette; Haynes, Barton F; Bartesaghi, Alberto; Acharya, Priyamvada Nature communications 37188681 2023 May 15
Structure of coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor. Childers, Kenneth C; Avery, Nathan G; Estrada Alamo, Kevin A; Davulcu, Omar; Haynes, Rose Marie; Lollar, Pete; Doering, Christopher B; Coxon, Carmen H; Spiegel, P Clint Blood 37192299 2023 Jul 13
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Cryo-EM structure of the Saccharomyces cerevisiae Rpd3L histone deacetylase complex. Patel, Avinash B; Qing, Jinkang; Tam, Kelly H; Zaman, Sara; Luiso, Maria; Radhakrishnan, Ishwar; He, Yuan Nature communications 37244892 2023 May 27
Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ. Chen, Siyu; Vogt, Alex; Lee, Linda; Naila, Tasmin; McKeown, Ryan; Tomkinson, Alan E; Lees-Miller, Susan P; He, Yuan Science advances 37256947 2023 Jun 02
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GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Hoppe, Nicholas; Harrison, Simone; Hwang, Sun-Hee; Chen, Ziwei; Karelina, Masha; Deshpande, Ishan; Suomivuori, Carl-Mikael; Palicharla, Vivek R; Berry, Samuel P; Tschaikner, Philipp; Regele, Dominik; Covey, Douglas F; Stefan, Eduard; Marks, Debora S; Reit bioRxiv : the preprint server for biology 37292845 2023 May 24
Structural basis of TFIIIC-dependent RNA Polymerase III transcription initiation. Talyzina, Anna; Han, Yan; Banerjee, Chiranjib; Fishbain, Susan; Reyes, Alexis; Vafabakhsh, Reza; He, Yuan bioRxiv : the preprint server for biology 37292922 2023 May 16
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High-resolution cryo-EM structure of the Pseudomonas bacteriophage E217. Li, Fenglin; Hou, Chun-Feng David; Lokareddy, Ravi K; Yang, Ruoyu; Forti, Francesca; Briani, Federica; Cingolani, Gino Nature communications 37422479 2023 Jul 08
Focusing antibody responses to the fusion peptide in rhesus macaques. Cottrell, Christopher A; Pratap, Payal P; Cirelli, Kimberly M; Carnathan, Diane G; Enemuo, Chiamaka A; Antanasijevic, Aleksandar; Ozorowski, Gabriel; Sewall, Leigh M; Gao, Hongmei; Greene, Kelli M; Allen, Joel D; Ngo, Julia T; Choe, Yury; Nogal, Bartek; Silva, Murillo; Bhiman, Jinal; Pauthner, Matthias; Irvine, Darrell J; Montefiori, David; Crispin, Max; Burton, Dennis R; Silvestri, Guido; Crotty, Shane; Ward, Andrew B bioRxiv : the preprint server for biology 37425865 2023 Jun 27
Structures and membrane interactions of native serotonin transporter in complexes with psychostimulants. Yang, Dongxue; Zhao, Zhiyu; Tajkhorshid, Emad; Gouaux, Eric Proceedings of the National Academy of Sciences of the United States of America 37436958 2023 Jul 18
Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex. Jiou, Jenny; Shaffer, Joy M; Bernades, Natalia E; Fung, Ho Yee Joyce; Kikumoto Dias, Juliana; D'Arcy, Sheena; Chook, Yuh Min Proceedings of the National Academy of Sciences of the United States of America 37450495 2023 Jul 18
Conformational trajectory of allosteric gating of the human cone photoreceptor cyclic nucleotide-gated channel. Hu, Zhengshan; Zheng, Xiangdong; Yang, Jian Nature communications 37463923 2023 Jul 18
Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry. Leonhardt, Susan A; Purdy, Michael D; Grover, Jonathan R; Yang, Ziwei; Poulos, Sandra; McIntire, William E; Tatham, Elizabeth A; Erramilli, Satchal K; Nosol, Kamil; Lai, Kin Kui; Ding, Shilei; Lu, Maolin; Uchil, Pradeep D; Finzi, Andrés; Rein, Alan; Kossiakoff, Anthony A; Mothes, Walther; Yeager, Mark Nature communications 37474505 2023 Jul 20
Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants. Li, Min; Oliveira Passos, Dario; Shan, Zelin; Smith, Steven J; Sun, Qinfang; Biswas, Avik; Choudhuri, Indrani; Strutzenberg, Timothy S; Haldane, Allan; Deng, Nanjie; Li, Zhaoyang; Zhao, Xue Zhi; Briganti, Lorenzo; Kvaratskhelia, Mamuka; Burke Jr, Terrence R; Levy, Ronald M; Hughes, Stephen H; Craigie, Robert; Lyumkis, Dmitry Science advances 37478179 2023 Jul 21
Integrated Fluorescence Microscopy (iFLM) for Cryo-FIB-milling and In-situ Cryo-ET. Yang, Jae; Vrbovská, Veronika; Franke, Tilman; Sibert, Bryan; Larson, Matthew; Hall, Alex; Rigort, Alex; Mitchels, John; Wright, Elizabeth R bioRxiv : the preprint server for biology 37502891 2023 Jul 12
Handling difficult cryo-ET samples: A study with primary neurons from Drosophila melanogaster. Kim, Joseph Y; Yang, Jie E; Mitchell, Josephine W; English, Lauren A; Yang, Sihui Z; Tenpas, Tanner; Dent, Erik W; Wildonger, Jill; Wright, Elizabeth R bioRxiv : the preprint server for biology 37502991 2023 Jul 11
Atomic-level architecture of Caulobacter crescentus flagellar filaments provide evidence for multi-flagellin filament stabilization. Sanchez, Juan C; Montemayor, Eric J; Ploscariu, Nicoleta T; Parrell, Daniel; Baumgardt, Joseph K; Yang, Jie E; Sibert, Bryan; Cai, Kai; Wright, Elizabeth R bioRxiv : the preprint server for biology 37503001 2023 Jul 10
Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin. Neuberger, Arthur; Trofimov, Yury A; Yelshanskaya, Maria V; Khau, Jeffrey; Nadezhdin, Kirill D; Khosrof, Lena S; Krylov, Nikolay A; Efremov, Roman G; Sobolevsky, Alexander I Nature communications 37532722 2023 Aug 02
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Extracellular filaments revealed by affinity capture cryo-electron tomography of lymphocytes. Engel, Leeya; Zaoralova, Magda; Dunn, Alexander R; Oliver, Stefan bioRxiv : the preprint server for biology 37577490 2023 Aug 06
Structural insights into opposing actions of neurosteroids on GABAA receptors. Legesse, Dagimhiwat H; Fan, Chen; Teng, Jinfeng; Zhuang, Yuxuan; Howard, Rebecca J; Noviello, Colleen M; Lindahl, Erik; Hibbs, Ryan E Nature communications 37607940 2023 Aug 22
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The National Center for CryoEM Access and Training - Establishing a Cross-Facility-Honored Training Curriculum. Eng, Edward T; Zimanyi, Christina; Aragon, Mahira; Chua, Eugene Y D; Kopylov, Elina; Dubbeldam, Charlie; Castello, Cathleen; Kieft, Jeffrey S; de Marco, Alex Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 37613291 2023 Jul 22
Cryo-EM Pipeline for Pharmaceutical and Biotechnology Industries. Kumar, Anil; Cai, Kai; Larson, Matt R; Sibert, Bryan S; Yang, Jae E; Wright, Elizabeth R Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 37613370 2023 Jul 22
Structural and Functional Analysis of Flagellar Filaments of Caulobacter crescentus. Sanchez, Juan C; Montemayor, Eric J; Ploscariu, Nicoleta T; Parrell, Daniel D; Yang, Jae; Sibert, Bryan; Cai, Kai; Wright, Elizabeth R Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 37613764 2023 Jul 22
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CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanism. Xu, Mengyuan; Neelands, Torben; Powers, Alexander S; Liu, Yan; Miller, Steven D; Pintilie, Grigore; Bois, J Du; Dror, Ron O; Chiu, Wah; Maduke, Merritt bioRxiv : the preprint server for biology 37645939 2023 Nov 29
Modulation of GluA2-γ5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2. Gangwar, Shanti Pal; Yen, Laura Y; Yelshanskaya, Maria V; Korman, Aryeh; Jones, Drew R; Sobolevsky, Alexander I Nature structural & molecular biology 37653241 2023 Oct
The Structures of Secretory IgA in complex with Streptococcus pyogenes M4 and human CD89 provide insights on mucosal host-pathogen interactions. Liu, Qianqiao; Stadtmueller, Beth M bioRxiv : the preprint server for biology 37662389 2023 Aug 26
Substrate binding and inhibition of the anion exchanger 1 transporter. Capper, Michael J; Yang, Shifan; Stone, Alexander C; Vatansever, Sezen; Zilberg, Gregory; Mathiharan, Yamuna Kalyani; Habib, Raul; Hutchinson, Keino; Zhao, Yihan; Schlessinger, Avner; Mezei, Mihaly; Osman, Roman; Zhang, Bin; Wacker, Daniel Nature structural & molecular biology 37679563 2023 Oct
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C. elegans Dicer acts with the RIG-I-like helicase DRH-1 and RDE-4 to cleave dsRNA. Consalvo, Claudia D; Aderounmu, Adedeji M; Donelick, Helen M; Aruscavage, P Joe; Eckert, Debra M; Shen, Peter S; Bass, Brenda L bioRxiv : the preprint server for biology 37790392 2023 Oct 26
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A Suite of Designed Protein Cages Using Machine Learning Algorithms and Protein Fragment-Based Protocols. Meador, Kyle; Castells-Graells, Roger; Aguirre, Roman; Sawaya, Michael R; Arbing, Mark A; Sherman, Trent; Senarathne, Chethaka; Yeates, Todd O bioRxiv : the preprint server for biology 37873110 2023 Oct 09
Fabrication of membrane proteins in the form of native cell membrane nanoparticles using novel membrane active polymers. Hoang Trinh, Thi Kim; Catalano, Claudio; Guo, Youzhong Nanoscale advances 37881706 2023 Oct 24
Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain. Small, Gabriel I; Fedorova, Olga; Olinares, Paul Dominic B; Chandanani, Joshua; Banerjee, Anoosha; Choi, Young Joo; Molina, Henrik; Chait, Brian T; Darst, Seth A; Campbell, Elizabeth A Molecular cell 37890482 2023 Nov 02
Molecular basis for Nse5-6 mediated regulation of Smc5/6 functions. Li, Shibai; Yu, You; Zheng, Jian; Miller-Browne, Victoria; Ser, Zheng; Kuang, Huihui; Patel, Dinshaw J; Zhao, Xiaolan Proceedings of the National Academy of Sciences of the United States of America 37903273 2023 Nov 07
Energy coupling and stoichiometry of Zn2+/H+ antiport by the prokaryotic cation diffusion facilitator YiiP. Hussein, Adel; Fan, Shujie; Lopez-Redondo, Maria; Kenney, Ian; Zhang, Xihui; Beckstein, Oliver; Stokes, David L eLife 37906094 2023 Oct 31
Structural basis for the allosteric regulation and dynamic assembly of DNMT3B. Lu, Jiuwei; Fang, Jian; Zhu, Hongtao; Liang, Kimberly Lu; Khudaverdyan, Nelli; Song, Jikui Nucleic acids research 37941146 2023 Dec 11
Molecular Architecture of Salmonella Typhimurium Virus P22 Genome Ejection Machinery. Iglesias, Stephano M; Lokareddy, Ravi K; Yang, Ruoyu; Li, Fenglin; Yeggoni, Daniel P; David Hou, Chun-Feng; Leroux, Makayla N; Cortines, Juliana R; Leavitt, Justin C; Bird, Mary; Casjens, Sherwood R; White, Simon; Teschke, Carolyn M; Cingolani, Gino Journal of molecular biology 37952769 2023 Dec 15
Cryo-electron tomography reveals the structural diversity of cardiac proteins in their cellular context. Woldeyes, Rahel A; Nishiga, Masataka; Vander Roest, Alison S; Engel, Leeya; Giri, Prerna; Montenegro, Gabrielle C; Wu, Andrew C; Dunn, Alexander R; Spudich, James A; Bernstein, Daniel; Schmid, Michael F; Wu, Joseph C; Chiu, Wah bioRxiv : the preprint server for biology 37961228 2023 Oct 26
Molecular Basis of Human Trace Amine-Associated Receptor 1 Activation. Zilberg, Gregory; Parpounas, Alexandra K; Warren, Audrey L; Yang, Shifan; Wacker, Daniel bioRxiv : the preprint server for biology 37986760 2023 Sep 07
Structural Insights into the Unexpected Agonism of Tetracyclic Antidepressants at Serotonin Receptors 5-HT1eR and 5-HT1FR. Zilberg, Gregory; Parpounas, Alexandra K; Warren, Audrey L; Fiorillo, Bianca; Provasi, Davide; Filizola, Marta; Wacker, Daniel bioRxiv : the preprint server for biology 37986777 2023 Oct 07
Structural basis of Gabija anti-phage defence and viral immune evasion. Antine, Sadie P; Johnson, Alex G; Mooney, Sarah E; Leavitt, Azita; Mayer, Megan L; Yirmiya, Erez; Amitai, Gil; Sorek, Rotem; Kranzusch, Philip J Nature 37992757 2024 Jan
Tad and toxin-coregulated pilus structures reveal unexpected diversity in bacterial type IV pili. Sonani, Ravi R; Sanchez, Juan Carlos; Baumgardt, Joseph K; Kundra, Shivani; Wright, Elizabeth R; Craig, Lisa; Egelman, Edward H Proceedings of the National Academy of Sciences of the United States of America 38011558 2023 Dec 05
Engineered odorant receptors illuminate structural principles of odor discrimination. de March, Claire A; Ma, Ning; Billesbølle, Christian B; Tewari, Jeevan; Del Torrent, Claudia Llinas; van der Velden, Wijnand J C; Ojiro, Ichie; Takayama, Ikumi; Faust, Bryan; Li, Linus; Vaidehi, Nagarajan; Manglik, Aashish; Matsunami, Hiroaki bioRxiv : the preprint server for biology 38014344 2023 Nov 17
An in vitro experimental pipeline to characterize the epitope of a SARS-CoV-2 neutralizing antibody. Atanasoff, Kristina E; Brambilla, Luca; Adelsberg, Daniel C; Kowdle, Shreyas; Stevens, Christian S; Slamanig, Stefan; Hung, Chuan-Tien; Fu, Yanwen; Lim, Reyna; Tran, Linh; Allen, Robert; Sun, Weina; Duty, J Andrew; Bajic, Goran; Lee, Benhur; Tortorella, Domenico mBio 38054729 2024 Jan 16
Structural basis for flagellin-induced NAIP5 activation. Paidimuddala, Bhaskar; Cao, Jianhao; Zhang, Liman Science advances 38055825 2023 Dec 08
Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Kretsch, Rachael C; Xu, Lily; Zheludev, Ivan N; Zhou, Xueting; Huang, Rui; Nye, Grace; Li, Shanshan; Zhang, Kaiming; Chiu, Wah; Das, Rhiju bioRxiv : the preprint server for biology 38076883 2023 Nov 27
Structural dynamics of GluK2 kainate receptors in apo and partial agonist bound states. Bogdanović, Nebojša; Segura-Covarrubias, Guadalupe; Zhang, Lisa; Tajima, Nami Research square 38076992 2023 Dec 02
Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method. Rosenberg, Gregory M; Abskharon, Romany; Boyer, David R; Ge, Peng; Sawaya, Michael R; Eisenberg, David S PNAS nexus 38077690 2023 Dec
A unified Watson-Crick geometry drives transcription of six-letter expanded DNA alphabets by E. coli RNA polymerase. Oh, Juntaek; Shan, Zelin; Hoshika, Shuichi; Xu, Jun; Chong, Jenny; Benner, Steven A; Lyumkis, Dmitry; Wang, Dong Nature communications 38086811 2023 Dec 12
Structures, functions and adaptations of the human LINE-1 ORF2 protein. Baldwin, Eric T; van Eeuwen, Trevor; Hoyos, David; Zalevsky, Arthur; Tchesnokov, Egor P; Sánchez, Roberto; Miller, Bryant D; Di Stefano, Luciano H; Ruiz, Francesc Xavier; Hancock, Matthew; Işik, Esin; Mendez-Dorantes, Carlos; Walpole, Thomas; Nichols, Charles; Wan, Paul; Riento, Kirsi; Halls-Kass, Rowan; Augustin, Martin; Lammens, Alfred; Jestel, Anja; Upla, Paula; Xibinaku, Kera; Congreve, Samantha; Hennink, Maximiliaan; Rogala, Kacper B; Schneider, Anna M; Fairman, Jennifer E; Christensen, Shawn M; Desrosiers, Brian; Bisacchi, Gregory S; Saunders, Oliver L; Hafeez, Nafeeza; Miao, Wenyan; Kapeller, Rosana; Zaller, Dennis M; Sali, Andrej; Weichenrieder, Oliver; Burns, Kathleen H; Götte, Matthias; Rout, Michael P; Arnold, Eddy; Greenbaum, Benjamin D; Romero, Donna L; LaCava, John; Taylor, Martin S Nature 38096902 2024 Feb
Structures of the promoter-bound respiratory syncytial virus polymerase. Cao, Dongdong; Gao, Yunrong; Chen, Zhenhang; Gooneratne, Inesh; Roesler, Claire; Mera, Cristopher; D'Cunha, Paul; Antonova, Anna; Katta, Deepak; Romanelli, Sarah; Wang, Qi; Rice, Samantha; Lemons, Wesley; Ramanathan, Anita; Liang, Bo Nature 38123676 2023 Dec 20
Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19. Padi, Sathish K R; Vos, Margaret R; Godek, Rachel J; Fuller, James R; Kruse, Thomas; Hein, Jamin B; Nilsson, Jakob; Kelker, Matthew S; Page, Rebecca; Peti, Wolfgang Nature 38123684 2024 Jan
B56δ long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations. Wu, Cheng-Guo; Balakrishnan, Vijaya K; Merrill, Ronald A; Parihar, Pankaj S; Konovolov, Kirill; Chen, Yu-Chia; Xu, Zhen; Wei, Hui; Sundaresan, Ramya; Cui, Qiang; Wadzinski, Brian E; Swingle, Mark R; Musiyenko, Alla; Chung, Wendy K; Honkanen, Richard E; Suzuki, Aussie; Huang, Xuhui; Strack, Stefan; Xing, Yongna Proceedings of the National Academy of Sciences of the United States of America 38150499 2024 Jan 02
Molecular basis of human trace amine-associated receptor 1 activation. Zilberg, Gregory; Parpounas, Alexandra K; Warren, Audrey L; Yang, Shifan; Wacker, Daniel Nature communications 38168118 2024 Jan 02
Mechanism of anion exchange and small-molecule inhibition of pendrin. Wang, Lie; Hoang, Anthony; Gil-Iturbe, Eva; Laganowsky, Arthur; Quick, Matthias; Zhou, Ming Nature communications 38184688 2024 Jan 06
Product analog binding identifies the copper active site of particulate methane monooxygenase. Tucci, Frank J; Jodts, Richard J; Hoffman, Brian M; Rosenzweig, Amy C Nature catalysis 38187819 2023 Dec
Structural basis for nuclear import of hepatitis B virus (HBV) nucleocapsid core. Yang, Ruoyu; Ko, Ying-Hui; Li, Fenglin; Lokareddy, Ravi K; Hou, Chun-Feng David; Kim, Christine; Klein, Shelby; Antolínez, Santiago; Marín, Juan F; Pérez-Segura, Carolina; Jarrold, Martin F; Zlotnick, Adam; Hadden-Perilla, Jodi A; Cingolani, Gino Science advances 38198557 2024 Jan 12
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nguyen, Binh An; Singh, Virender; Afrin, Shumaila; Yakubovska, Anna; Wang, Lanie; Ahmed, Yasmin; Pedretti, Rose; Fernandez-Ramirez, Maria Del Carmen; Singh, Preeti; Pękała, Maja; Cabrera Hernandez, Luis O; Kumar, Siddharth; Lemoff, Andrew; Gonzalez-Prieto, Roman; Sawaya, Michael R; Eisenberg, David S; Benson, Merrill Douglas; Saelices, Lorena Nature communications 38233397 2024 Jan 17
Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Hu, Qi; Zhao, Debiao; Cui, Gaofeng; Bhandari, Janarjan; Thompson, James R; Botuyan, Maria Victoria; Mer, Georges Molecular cell 38242129 2024 Mar 07
Structures of the essential efflux pump EfpA from Mycobacterium tuberculosis reveal the mechanisms of substrate transport and small-molecule inhibition. Wang, Shuhui; Wang, Kun; Song, Kangkang; Li, Pengfei; Li, Dongying; Sun, Yajie; Mei, Ye; Xu, Chen; Liao, Maofu Research square 38260587 2024 Jan 05
Recent advances in infectious disease research using cryo-electron tomography. Asarnow, Daniel; Becker, Vada A; Bobe, Daija; Dubbledam, Charlie; Johnston, Jake D; Kopylov, Mykhailo; Lavoie, Nathalie R; Li, Qiuye; Mattingly, Jacob M; Mendez, Joshua H; Paraan, Mohammadreza; Turner, Jack; Upadhye, Viraj; Walsh Jr, Richard M; Gupta, Meghna; Eng, Edward T Frontiers in molecular biosciences 38288336 2023
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Hoppe, Nicholas; Harrison, Simone; Hwang, Sun-Hee; Chen, Ziwei; Karelina, Masha; Deshpande, Ishan; Suomivuori, Carl-Mikael; Palicharla, Vivek R; Berry, Samuel P; Tschaikner, Philipp; Regele, Dominik; Covey, Douglas F; Stefan, Eduard; Marks, Debora S; Reiter, Jeremy F; Dror, Ron O; Evers, Alex S; Mukhopadhyay, Saikat; Manglik, Aashish Nature structural & molecular biology 38326651 2024 Feb 07
CryoCycle your grids: Plunge vitrifying and reusing clipped grids to advance cryoEM democratization. Serbynovskyi, Viacheslav; Wang, Jing; Chua, Eugene Yd; Ishemgulova, Aygul; Alink, Lambertus M; Budell, William C; Johnston, Jake D; Dubbeldam, Charlie; Gonzalez, Fabio A; Rozovsky, Sharon; Eng, Edward T; de Marco, Alex; Noble, Alex J bioRxiv : the preprint server for biology 38328036 2024 Feb 01
CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism. Xu, Mengyuan; Neelands, Torben; Powers, Alexander S; Liu, Yan; Miller, Steven D; Pintilie, Grigore D; Bois, J Du; Dror, Ron O; Chiu, Wah; Maduke, Merritt eLife 38345841 2024 Feb 12
Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications. Cookis, Trinity; Lydecker, Alexandria; Sauer, Paul; Kasinath, Vignesh; Nogales, Eva bioRxiv : the preprint server for biology 38370759 2024 Feb 10
Mobile barrier mechanisms for Na+-coupled symport in an MFS sugar transporter. Hariharan, Parameswaran; Shi, Yuqi; Katsube, Satoshi; Willibal, Katleen; Burrows, Nathan D; Mitchell, Patrick; Bakhtiiari, Amirhossein; Stanfield, Samantha; Pardon, Els; Kaback, H Ronald; Liang, Ruibin; Steyaert, Jan; Viner, Rosa; Guan, Lan eLife 38381130 2024 Feb 21
Structural mechanisms of α7 nicotinic receptor allosteric modulation and activation. Burke, Sean M; Avstrikova, Mariia; Noviello, Colleen M; Mukhtasimova, Nuriya; Changeux, Jean-Pierre; Thakur, Ganesh A; Sine, Steven M; Cecchini, Marco; Hibbs, Ryan E Cell 38382524 2024 Feb 29
Miffi: Improving the accuracy of CNN-based cryo-EM micrograph filtering with fine-tuning and Fourier space information. Xu, Da; Ando, Nozomi bioRxiv : the preprint server for biology 38405773 2024 Feb 27
Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Kretsch, Rachael C; Xu, Lily; Zheludev, Ivan N; Zhou, Xueting; Huang, Rui; Nye, Grace; Li, Shanshan; Zhang, Kaiming; Chiu, Wah; Das, Rhiju Proceedings of the National Academy of Sciences of the United States of America 38427602 2024 Mar 05
Mapping Protein-Protein Interactions at Birth: Single-Particle Cryo-EM Analysis of a Ribosome-Nascent Globin Complex. Masse, Meranda M; Hutchinson, Rachel B; Morgan, Christopher E; Allaman, Heather J; Guan, Hongqing; Yu, Edward W; Cavagnero, Silvia ACS central science 38435509 2024 Feb 28
Filament formation drives catalysis by glutaminase enzymes important in cancer progression. Feng, Shi; Aplin, Cody; Nguyen, Thuy-Tien T; Milano, Shawn K; Cerione, Richard A Nature communications 38438397 2024 Mar 04
Structural bases for stoichiometry-selective calcium potentiation of a neuronal nicotinic receptor. Mazzaferro, Simone; Kang, Guipeun; Natarajan, Kathiresan; Hibbs, Ryan E; Sine, Steven M British journal of pharmacology 38454578 2024 Mar 07
Integrative structural analysis of Pseudomonas phage DEV reveals a genome ejection motor. Cingolani, Gino; Lokareddy, Ravi; Hou, Chun-Feng; Forti, Francesca; Iglesias, Stephano; Li, Fenglin; Pavlenok, Mikhail; Niederweis, Michael; Briani, Federica Research square 38463957 2024 Feb 21
Human calpain-3 and its structural plasticity: dissociation of a homohexamer into dimers on binding titin. Ye, Qilu; Henrickson, Amy; Demeler, Borries; Serrão, Vitor Hugo Balasco; Davies, Peter L bioRxiv : the preprint server for biology 38464089 2024 Mar 03
Protective effect and molecular mechanisms of human non-neutralizing cross-reactive spike antibodies elicited by SARS-CoV-2 mRNA vaccination. Clark, Jordan; Hoxie, Irene; Adelsberg, Daniel C; Sapse, Iden A; Andreata-Santos, Robert; Yong, Jeremy S; Amanat, Fatima; Tcheou, Johnstone; Raskin, Ariel; Singh, Gagandeep; González-Domínguez, Irene; Edgar, Julia E; Bournazos, Stylianos; Sun, Weina; Carreño, Juan Manuel; Simon, Viviana; Ellebedy, Ali H; Bajic, Goran; Krammer, Florian bioRxiv : the preprint server for biology 38464151 2024 Mar 01
Blueprinting extendable nanomaterials with standardized protein blocks. Huddy, Timothy F; Hsia, Yang; Kibler, Ryan D; Xu, Jinwei; Bethel, Neville; Nagarajan, Deepesh; Redler, Rachel; Leung, Philip J Y; Weidle, Connor; Courbet, Alexis; Yang, Erin C; Bera, Asim K; Coudray, Nicolas; Calise, S John; Davila-Hernandez, Fatima A; Han, Hannah L; Carr, Kenneth D; Li, Zhe; McHugh, Ryan; Reggiano, Gabriella; Kang, Alex; Sankaran, Banumathi; Dickinson, Miles S; Coventry, Brian; Brunette, T J; Liu, Yulai; Dauparas, Justas; Borst, Andrew J; Ekiert, Damian; Kollman, Justin M; Bhabha, Gira; Baker, David Nature 38480887 2024 Mar
VitroJet: new features and case studies. Henderikx, Rene J M; Mann, Daniel; Domanska, Aušra; Dong, Jing; Shahzad, Saba; Lak, Behnam; Filopoulou, Aikaterini; Ludig, Damian; Grininger, Martin; Momoh, Jeffrey; Laanto, Elina; Oksanen, Hanna M; Bisikalo, Kyrylo; Williams, Pamela A; Butcher, Sarah J; Peters, Peter J; Beulen, Bart W A M M Acta crystallographica. Section D, Structural biology 38488730 2024 Apr 01
Conformational landscape of soluble α-klotho revealed by cryogenic electron microscopy. Schnicker, Nicholas J; Xu, Zhen; Amir, Mohammad; Gakhar, Lokesh; Huang, Chou-Long bioRxiv : the preprint server for biology 38496408 2024 Mar 06
Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis. Nguyen, Binh An; Singh, Virender; Afrin, Shumaila; Singh, Preeti; Pekala, Maja; Ahmed, Yasmin; Pedretti, Rose; Canepa, Jacob; Lemoff, Andrew; Kluve-Beckerman, Barbara; Wydorski, Pawel; Chhapra, Farzeen; Saelices, Lorena bioRxiv : the preprint server for biology 38496656 2024 Mar 09
Structure of an open KATP channel reveals tandem PIP2 binding sites mediating the Kir6.2 and SUR1 regulatory interface. Driggers, Camden M; Kuo, Yi-Ying; Zhu, Phillip; ElSheikh, Assmaa; Shyng, Show-Ling Nature communications 38509107 2024 Mar 20
Structural mechanisms for VMAT2 inhibition by tetrabenazine. Dalton, Michael P; Cheng, Mary Hongying; Bahar, Ivet; Coleman, Jonathan A eLife 38517752 2024 Mar 22
Cryo-EM sample preparation for high-resolution structure studies. Wang, Liguo; Zimanyi, Christina M Acta crystallographica. Section F, Structural biology communications 38530656 2024 Apr 01
Structural basis for Retriever-SNX17 assembly and endosomal sorting. Singla, Amika; Boesch, Daniel J; Joyce Fung, Ho Yee; Ngoka, Chigozie; Enriquez, Avery S; Song, Ran; Kramer, Daniel A; Han, Yan; Juneja, Puneet; Billadeau, Daniel D; Bai, Xiaochen; Chen, Zhe; Turer, Emre E; Burstein, Ezra; Chen, Baoyu bioRxiv : the preprint server for biology 38559023 2024 Mar 13
Anti-Immune Complex Antibodies are Elicited During Repeated Immunization with HIV Env Immunogens. Brown, Sharidan; Antanasijevic, Aleksandar; Sewall, Leigh M; Garcia, Daniel Montiel; Brouwer, Philip J M; Sanders, Rogier W; Ward, Andrew B bioRxiv : the preprint server for biology 38559180 2024 Mar 17

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