Funded Research

2017 NIH Director's Early Independence Award (DP5) - RFA-RM-16-006

PI Name Institution Name Title
ARBOLEDA, VALERIE ANNE

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Unraveling CorrelationsBetween Mendelian and Common Disease Using Functional Genomics

 

BADRAN, AHMED HUSSEIN

 

HARVARD UNIVERSITY

 

Functional Interrogation of Ribosomal Biology Using Continuous Evolution

 

CHEN, FEI

 

BROAD INSTITUTE, INC.

 

Characterizing Glioma Heterogeneity with Novel Multiplexed Nanoscale Imaging Technologies

 

EAGEN, KYLE PATRICK

 

NORTHWESTERN UNIVERSITY AT CHICAGO

 

Biochemical Basis of Chromatin Folding and Chromosome Condensation

 

FINUCANE, HILARY

 

BROAD INSTITUTE, INC.

 

Identifying Disease-Relevant Cell Types by Integrating Genetic and Functional Genomics Data

 

GYMREK, MELISSA

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Systematic Identification and Interpretation of Repetitive Variants Underlying Schizophrenia

 

LOH, KYLE M

 

STANFORD UNIVERSITY

 

Developing Approaches for Universal Organ Transplantation

 

MEHR, SAMUEL A

 

HARVARD UNIVERSITY

 

Psychological Functions of Music in Infancy

 

MORRIS, ZACHARY SCOTT

 

UNIVERSITY OF WISCONSIN-MADISON

 

Combining Radiation and Tumor-Specific Antibody Therapies to Elicit In Situ Tumor Vaccination

 

SONG, ZIRUI

 

HARVARD MEDICAL SCHOOL

 

Inequities in Health Outcomes in the Twenty-First Century: Understanding New Causes and the Impact of Delivery System Reforms on Health Care Disparities

 

ZHOU, CHUANKAI

 

BUCK INSTITUTE FOR RESEARCH ON AGING

 

Mechanism of Organelle Dysfunction during Aging and the Related Rejuvenation Process

 

 

2016 NIH Director's Early Independence Award (DP5) - RFA-RM-15-006

PI Name Institution Name Title
ABRAHAM, JONATHAN

 

BRIGHAM AND WOMEN'S HOSPITAL

 

Antibody Therapeutics for Human Viral Hemorrhagic Fevers and Prevention of Late Neurological Syndromes

 

BIND, MARIE-ABELE CATHERINE

 

HARVARD UNIVERSITY

 

Transporting Established Insights from Classical Experimental Design to Address Causal Questions in Environmental Epidemiology, Including the Understanding of Biological Mediating Mechanisms

 

BRUNKARD, JACOB O

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

An Aminoacyl tRNA Synthetase is a Nitrogen Sensor that Activates TOR in Plants

 

DEKOSKY, BRANDON JAMES

 

UNIVERSITY OF KANSAS LAWRENCE

 

Comprehensive Analysis of Human Adaptive Immune Receptors to Elucidate Correlates of Epstein-Barr Virus Disease Suppression

 

DIVITO, SHERRIE JILL

 

BRIGHAM AND WOMEN'S HOSPITAL

 

Investigating a Novel Cell Population in Delayed-Onset Drug Hypersensitivity Reactions

 

DIXON, JESSE

 

SALK INSTITUTE FOR BIOLOGICAL STUDIES

 

Mechanisms of Formation of 3D Genome Structures

 

GANTZ, VALENTINO MATTEO

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Development, Characterization and Application of CRISPR/Cas9 Gene Drive Technologies and Related Active Genetic Elements to Benefit Research and Society at Large

 

GIOVENCO, DANIEL PHILIP

 

RBHS-SCHOOL OF PUBLIC HEALTH

 

Geographic Variation in the Diverse Tobacco Retail Environment and Its Impact on Tobacco Use Disparities

 

KOENIG, KRISTEN MARIE

 

HARVARD UNIVERSITY

 

Investigating Organ Formation and the Emergence of Complexity in the Visual System Using Comparative Developmental Approaches

 

MANGLIK, AASHISH

 

STANFORD UNIVERSITY

 

Molecular Mechanisms of Iron Homeostasis

 

MARTINEZ-BAKKER, MICAELA ELVIRA

 

PRINCETON UNIVERSITY

 

Hackinig Epidemics: Unlocking the Drivers of Transmission Seasonality to Battle Vaccome-Preventable Diseases

 

MUGNIER, MONICA

 

JOHNS HOPKINS UNIVERSITY

 

Variant Surface Glycoprotein Diversification in Trypanosoma brucei

 

RAMIREZ, STEVE

 

HARVARD UNIVERSITY

 

Artificially Modulating Memories to Alleviate Psychiatric Disease-Like States

 

RING, AARON MICHAEL

 

YALE UNIVERSITY

 

Uncoupling Pleiotropy in the LIGHT/HVEM/LTBetaR Signaling Network

 

SPITZER, MATTHEW

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Quantitatively Modeling Immune Responses to Cancer

 

YACKLE, KEVIN

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Cellular and Molecular Identification of the Breathing Pacemaker Neurons

 

 

2015 NIH Director's Early Independence Award (DP5) - RFA-RM-14-004

PI Name Institution Name Title
BONDY-DENOMY, JOSEPH

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Discovering New Roles for CRISPR-Cas in Bacterial Pathogenesis 

 

BRAGG, MARIE

 

NEW YORK UNIVERSITY SCHOOL OF MEDICINE

 

Impact of Racially Targeted Food and Beverage Ads on Adolescent Behavior

 

DEMEHRI, SHADMEHR

 

WASHINGTON UNIVERSITY

 

The Mechanism of TSLP Anti-Tumor Effects in the Skin

 

GADE, TERENCE P

 

UNIVERSITY OF PENNSYLVANIA

 

Image-Based Phenotyping of Hepatocellular Carcinoma Cell Survival under Ischemic Stress: Toward Metabolic Imaging of Cancer Dormancy Using Hyperpolarized Carbon-13 Technology

 

GEE, DYLAN

 

YALE UNIVERSITY

 

Novel Mechanisms of Fear Reduction Targeting the Biological State of the Developing Brain

 

GREENBLATT, MATTHEW BLAKE

 

WEILL MEDICAL COLL OF CORNELL UNIV

 

Modulation of Bone Formation by SHN3

 

HILL, ELAINE

 

UNIVERSITY OF ROCHESTER

 

The Health Consequences of Shale Gas Development

 

HSU, PATRICK DAVID

 

SALK INSTITUTE FOR BIOLOGICAL STUDIES

 

Eukaryotic Transcriptome Engineering via Sequence-Specific Regulation of Endogenous RNA

 

ISRAELSEN, WILLIAM JAMES

 

UT SOUTHWESTERN MEDICAL CENTER

 

Development and Use of a Novel, Tractable Rodent Model for Studies of Hibernation Metabolism

 

KRUSE, ANDREW

 

HARVARD COLLEGE

 

Molecular Mechanisms of Adiponectin Signaling and PAQR Function

 

LYUMKIS, DMITRY

 

SALK INSTITUTE FOR BIOLOGICAL STUDIES

 

Breaking Barriers in Structural Biology: Novel CryoEM Methods and Applications

 

MEDAGLIA, JOHN

 

UNIVERSITY OF PENNSYLVANIA

 

Dynamic Network Neuroscience and Control Theory: Toward Interventions for Cognitive Control Dysfunction

 

SHELTZER, JASON

 

COLD SPRING HARBOR LABORATORY

 

Identification and Characterization of Genomic Features Affecting Survival Duration in Cancer

 

SOLOMON, DAVID A.

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Cohesin Gene Mutations in Tumorigenesis

 

SONABEND, ADAM M

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

TOP2A Effects on Transcription in Gliomas: Implications for Personalized Therapy

 

ZHANG, ZHAO

 

CARNEGIE INSTITUTION OF WASHINGTON

 

Somatic Transposition-Mediated Genome Variegation during Development, Disease and Aging Conditions

 

 

2014 NIH Director's Early Independence Award (DP5) - RFA-RM-13-009

PI Name Institution Name Titles
ALLISON, KYLE ROUSE

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

Isolation and Systems-Level Characterization of Persistent Bacteria

 

ANGELO, ROBERT MICHAEL

 

STANFORD UNIVERSITY

 

Predictive Signatures in Breast Cancer Using Multiplexed Ion Beam Imaging

 

BERGELSON, ELIKA

 

DUKE UNIVERSITY 

 

Mechanisms of Word Learning in Infancy

 

CHAN, DAVID CHIMIN

 

PALO ALTO INSTITUTE

 

The Benefit and Burden of Electronic Reminders for Optimizing Patient Care

 

ESCOLA, GARY SEAN

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

The Internal States of Neural Circuits: Data Analysis, Modeling, and Disease

 

HANNA, JOHN W

 

BRIGHAM AND WOMEN'S HOSPITAL

 

New Ubiquitin-Proteasome System Components that Protect against Proteotoxicity

 

HILL, ALISON LYNN

 

HARVARD UNIVERSITY

 

Quantification and Prediction of Treatment Efficacy for HIV Cure Strategies

 

HYSTAD, PERRY W>

 

OREGON STATE UNIVERSITY

 

PURE-AIR: A Global Assessment of Air Pollution and Cardiopulmonary Disease

 

JUDSON, ROBERT LAIRD

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

MicroRNA-Based Detection of Barriers to Melanoma Progression

 

MARU, DUNCAN

 

BRIGHAM AND WOMEN'S HOSPITAL

 

Integrating Pediatric Care Delivery in Rural Healthcare Systems

 

MEYER, AARON SAMUEL

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Adapter-Layer RTK Signaling: Basic Understanding & Targeted DrugResistance

 

NELSON, ERIC JORGE

 

STANFORD UNIVERSITY

 

A Novel Approach to Improve Patient Care and Diarrheal Disease Research Using Mobile Technology

 

QUIROZ, YAKEEL TATIANA

 

MASSACHUSETTS GENERAL HOSPITAL

 

Memory Network Dysfunction as an Early Marker of Preclinical Alzheimers Disease

 

RANDLES, AMANDA E

 

UNIVERSITY OF CALIF-LAWRNC LVRMR NAT LAB

 

Toward Coupled Multiphysics Models of Hemodynamics on Leadership Systems

 

SANTOS, GLENN-MILO

 

PUBLIC HEALTH FOUNDATION ENTERPRISES

 

The Better THAN Study: Targeting Heavy Alcohol with Naltrexone among MSM

 

SIMON, NOAH

 

UNIVERSITY OF WASHINGTON

 

Data-Driven Statistical Learning with Applications to Genomics

 

STOWELL, SEAN

 

EMORY UNIVERSITY

 

Examination of Innate Immunity Against Molecular Mimicry

 

 

2013 NIH Director's Early Independence Award (DP5) - RFA-RM-12-018

PI Name Institution Name Titles
ALUSHIN, GREGORY M

 

ROCKEFELLER UNIVERSITY

 

Mechanosensing via Cytoskeletal Strain

 

BACONGUIS, ISABELLE RHYSSA JOE EDURIA

 

OREGON HEALTH AND SCI UNIVERSITY

 

Structure and Function of Epithelial Sodium Channels

 

BJORNSSON, HANS TOMAS

 

JOHNS HOPKINS UNIVERSITY

 

Exploring Kabuki Syndrome as a Treatable Cause of Intellectual Disability

 

BRUENING, MEREDITH M

 

ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

 

The Role of Friendship Networks on BMI and Behaviors among College Freshmen

 

CARTER, HANNAH KATHRYN

 

UNIVERSITY OF CALIFORNIA

 

Network Approaches to Identify Cancer Drivers from High-Dimensional Tumor Data

 

DENNY, CHRISTINE ANN

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

Optogenetic Dissection of Hippocampal Circuitry Underlying Alzheimers Disease

 

HSIAO, ELAINE

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Uncovering Microbial Modulators of Neuroactive Molecules as Novel Therapeutics

 

JENA, ANUPAM BAPU

 

HARVARD UNIVERSITY (MEDICAL SCHOOL)

 

Physician Determinants of Health Care Spending, Quality, and Patient Outcomes

 

LOURIDO, SEBASTIAN

 

WHITEHEAD INSTITUTE FOR BIOMEDICAL RES

 

Dissecting Essential Signaling Pathways in Apicomplexan Parasites

 

LOVELL, JONATHAN F

 

STATE UNIVERSITY OF NEW YORK AT BUFFALO

 

Targeting Tumors with Resealable Nanovesicles Permeabilized by NIR Light

 

LUDINGTON, WILLIAM

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

Developing a Reduced Complexity Model Gut Microbiome in the Behavior Model, Drosophila, and Bacteriophage Therapies to Modulate Behavior through the Microbiome

 

PINCUS, DAVID

 

WHITEHEAD INSTITUTE FOR BIOMEDICAL RES

 

Quantitative Approaches to Reveal the Homeostatic Control Mechanisms of Stress Responses

 

QI, LEI STANLEY

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

A Novel RNA-Guided Platform for Sequence-Specific Cell Reprogramming

 

WANG, ERIC T

 

UNIVERSITY OF FLORIDA

 

Post-Transcriptional Regulation of Gene Expression in Neuromuscular Disease

 

WEINBERG, DAVID ERIC

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Formation and Regulation of the Translating mRNP

 

 

2012 NIH Director's Early Independence Award (DP5) - RFA-RM-11-007

PI Name Institution Name Titles
ANTICEVIC, ALAN

 

YALE UNIVERSITY

 

Characterizing Cognitive Impairment in Schizophrenia via Computational Modeling and Pharmacological Neuroimaging

 

BATISH, MONA

 

UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL

 

Detection of Chromosomal Translocations by Single Molecule RNA Imaging

 

CHEN, YVONNE

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Engineering of Computational Receptors and Gene Circuits for T-cell Immunotherapy

 

DE LA ZERDA, ADAM

 

STANFORD UNIVERSITY

 

Molecular Imaging of Protein Glycosylation in Living Subjects

 

FORNWALT, BRANDON K

 

UNIVERSITY OF KENTUCKY

 

Exploring the Role of Dyssynchrony in Pediatric Heart Disease with MRI

 

GUTTMAN, MITCHELL

 

BROAD INSTITUTE, INC.

 

Deciphering the Mechanism of Large ncRNA Mediated Regulation of Cell State

 

KAISER, WILLIAM JOSEPH

 

EMORY UNIVERSITY

 

RIP1 and RIP3 rRegulation of Apoptosis, Necrosis, and Inflammation

 

OBERMEYER, ZIAD

 

BRIGHAM AND WOMEN'S HOSPITAL

 

Unexpected Death after Medical Encounters: Measurement, Reporting, and Analysis

 

ROSENBERG, BRAD

 

ROCKEFELLER UNIVERSITY

 

Immune Profiling by High Throughput Sequencing of Complete Antigen Receptors

 

SONNENBERG, GREGORY F.

 

UNIVERSITY OF PENNSYLVANIA

 

Regulation of Host-Commensal Relationships in Human Health and Disease

 

THOMSON, MATTHEW

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Quantitative Models for Controlling Collective Cell Fate Selection in Stem Cells

 

VICTORA, GABRIEL D

 

WHITEHEAD INSTITUTE FOR BIOMEDICAL RES

 

In Vivo Approaches to Dissecting B Cell-T Cell Cooperation in Germinal Centers

 

VILLEDA, SAUL A

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Regulation of Neurogenesis and Cognition by Systemic Age-Related Immune Factors

 

YEH, ELLEN

 

STANFORD UNIVERSITY

 

Defining the Novel Eukaryotic Biology of the Apicomplexan Plastid

 

 

2011 NIH Director's Early Independence Award (DP5) - RFA-RM-10-019

PI Name Institution Name Titles
BASTA, NICOLE ELAINE

 

UNIVERSITY OF WASHINGTON

 

Antibody Persistence after Conjugate Meningococcal Group A Vaccination in Mali

 

CALARCO, JOHN ANTHONY

 

HARVARD UNIVERSITY

 

Investigating the Role of Alternative Splicing Regulatory Networks in Nervous System Development and Function

 

FRASER, JAMES SOLOMON

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

The Impact of Mutation on the Conformations and Recognition of Ubiquitin

 

HALFMANN, RANDAL ARTHUR

 

UNIVERSITY OF TEXAS SW MED CTR/DALLAS

 

Contributions of Protein Aggregation to Gene Regulation and Phenotypic Diversity

 

KIDD, JEFFREY M

 

STANFORD UNIVERSITY

 

Characterizing the Global Architecture of Genomic Diversity

 

LEPPER, CHRISTOPH

 

CARNEGIE INSTITUTION OF WASHINGTON, D.C.

 

Molecular Mechanisms of Muscle Stem Cells Transitioning Intoquiescence

 

OLSEN, CARISSA

 

FRED HUTCHINSON CANCER RESEARCH CENTER

 

Defining the Impact of Lipid Synthesis and Turnover on Aging in C. elegans

 

SAMACO, RODNEY C

 

BAYLOR COLLEGE OF MEDICINE

 

The Genetic and Neuroanatomical Origin of Social Behavior

 

WANG, HARRIS H

 

HARVARD UNIVERSITY (MEDICAL SCHOOL)

 

Functional Metagenomic Reprogramming of the Human Microbiome through Mobilome Engineering

 

WITTEN, DANIELA

 

UNIVERSITY OF WASHINGTON

 

High-Dimensional Unsupervised Learning, with Applications to Genomics

 

This page last reviewed on August 14, 2018