Program Snapshot

The goal of the Gabriella Miller Kids First Pediatric Research Program (Kids First) is to develop a large-scale data resource to help researchers uncover new insights into the biology of childhood cancer and structural birth defects, including the discovery of shared genetic pathways between these disorders. Children with birth defects have an increased risk of developing childhood cancer. This suggests there are shared genetic pathways underlying some types of childhood cancer and structural birth defects. Kids First is achieving this goal through two initiatives: 1) identifying children with childhood cancer and structural birth defects and their families for whole genome sequencing performed by the Kids First sequencing centers 2) the Gabriella Miller Kids First Data Resource. Analyzing genetic sequence data from children with childhood cancer and structural birth defects together may lead to the discovery of new genetic pathways.

The program was launched in 2015. Over 2015-2018, the program selected 26 patient cohorts for whole genome sequencing through a peer-review process and will be selecting additional cohorts in 2019-2022 pending the availability of funds.  In 2018, Kids First launched the Gabriella Miller Kids First Data Resource Portal, a large-scale database of clinical and genetic data from patients with childhood cancers and structural birth defects and their families. The portal was established through the Gabriella Miller Kids First Data Resource Center (DRC). To date, the program has sequenced more than 20,000 samples from childhood cancer and structural birth defects cohorts. Clinical and genetic sequence data from nine datasets are now publicly available through NIH the database of Genotypes and Phenotypes (dbGaP) and Data Resource Portal

For an overview of the Kids First Program watch the video below:


 


Gabriella Miller Kids First Program graphic identity featuring children with kites

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This page last reviewed on November 22, 2019