Acute to Chronic Pain Signatures
This program will develop a set of objective biomarkers that provide a “signature” to predict a transition from acute to chronic pain, in order to accelerate therapy development and ultimately to guide pain prevention strategies. These biomarkers are greatly needed as the number of people who transition from acute to chronic pain after an acute pain event is surprisingly high. This high prevalence of chronic pain in the US has in part contributed to the current opioid epidemic.
The Acute to Chronic Pain Signatures program will use advances in imaging, high-throughput biomedical experiments (‘omics), sensory testing, and psychosocial assessments to explore a range of characteristics from patients who transition or are resilient to chronic pain. The study will follow two groups from the time of acute pain event over a period of six months. One group will have post-operative pain and the other will have musculoskeletal trauma. The key deliverable of the program is a comprehensive data set for the research communities that should reveal “signatures” predictive of transition versus resilience to chronic pain.
This page last reviewed on September 10, 2018