Funded Research

 

Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed) RFA-RM-18-021
PI Name Institution Name Title

ARAC-OZKAN, DEMET

UNIVERSITY OF CHICAGO Structural and Functional Studies of Brain Angiogenesis Inhibitors (BAIs/ADGRBs)
CHAHROUR, MARIA UT SOUTHWESTERN MEDICAL CENTER Investigating the role of BCKDK in neurodevelopmental disorders through a novel mouse model

DEVI, LAKSHMI A

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI Targeted Deorphanization of G Protein-Coupled Receptors
FESKE, STEFAN NEW YORK UNIVERSITY SCHOOL OF MEDICINE Calcium channel CACNB1 in T cell function and immunity
GREEN, THOMAS ARTHUR (contact)
LAEZZA, FERNANDA
UNIVERSITY OF TEXAS MED BR GALVESTON Gpr12: a novel factor for addiction and mental health
ISOM, DANIEL UNIVERSITY OF MIAMI SCHOOL OF MEDICINE New CRISPR-based technologies for screening dark GPCRs
KU, GREGORY MICHAEL UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Uncovering Two Novel Diabetes Drug Targets in the IDG
LEE, AMY UNIVERSITY OF IOWA Illuminating the functions of CACNA2D4 in the brain
LODMELL, J STEPHEN UNIVERSITY OF MONTANA Role of the atypical protein kinase RIOK3 in the cellular antiviral response
MARTO, JARROD A DANA-FARBER CANCER INST Tools for the understudied kinase PNK3
NEWTON, ALEXANDRA C UNIVERSITY OF CALIFORNIA, SAN DIEGO Establishing Function of Understudied PRKCQ Kinase in Cellular Regulation and Disease
SEBAG, JULIEN ALBERT UNIVERSITY OF IOWA Identification of the central localization and regulation of the Prokineticin 1 Receptor, a novel target for the treatment of obesity
TAYLOR, SUSAN S UNIVERSITY OF CALIFORNIA, SAN DIEGO Illuminating the Role of understudied PRKACB Splice Variants in PKA Signaling
TURK, BENJAMIN E (contact)
CALDERWOOD, DAVID A
YALE UNIVERSITY Interaction of substrates and inhibitors with tousled-like kinase 2
WHIM, MATTHEW LSU HEALTH SCIENCES CENTER Determining the role of the adrenal Y2 and Y5 receptors in the prevention of hypoglycemia
WHITEHURST, ANGELIQUE WRIGHT UT SOUTHWESTERN MEDICAL CENTER Mechanisms and Models of Testis Specific Serine Kinase 6 (TSSK6)

 

Cutting Edge Informatics Tools for Illuminating the Druggable Genome (U01 Clinical Trial Not Allowed) RFA-RM-18-011
PI Name Institution Name Title
KANNAN, NATARAJAN (contact)
KOCHUT, KRZYSZTOF J.
UNIVERSITY OF GEORGIA A data analytics framework for mining the dark kinome
ROBINSON, PETER NICHOLAS (contact)
MUNGALL, CHRISTOPHER J
OPREA, TUDOR I
JACKSON LABORATORY Illuminating the Druggable Genome by Knowledge Graphs
WU, GUANMING (contact)
DEUSTACHIO, PETER G
STEIN, LINCOLN D.
OREGON HEALTH & SCIENCE UNIVERSITY Reactome IDG portal: Pathway-based analysis and visualization of understudied human proteins

 

Knowledge Management Center for Illuminating the Druggable Genome (U24) RFA-RM-16-024
PI Name Institution Name Title
MA'AYAN, AVI ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI Knowledge Management Center for Illuminating the Druggable Genome (Component Award)
OPREA, TUDOR I UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR Knowledge Management Center for Illuminating the Druggable Genome (Center Award)

 

Data and Resource Generation Centers for Illuminating the Druggable Genome (U24) RFA-RM-16-026
PI Name Institution Name Title
JOHNSON, GARY L UNIV OF NORTH CAROLINA CHAPEL HILL Illuminating Function of the Understudied Druggable Kinome
MCMANUS, MICHAEL T (contact) 
JAN, LILY Y
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Illuminating Druggable Dark Matter
ROTH, BRYAN L. (contact) 
SHOICHET, BRIAN K
UNIV OF NORTH CAROLINA CHAPEL HILL Illuminating the druggable GPCR-ome

 

Resource Dissemination and Outreach Center for Illuminating the Druggable Genome (U24) RFA-RM-16-025
PI Name Institution Name Title
SCHÜRER, STEPHAN C (contact) 
OPREA, TUDOR I 
SKLAR, LARRY A. 
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE Illuminating the Druggable Genome Resource Dissemination and Outreach Center (IDG-RDOC)

 

Development of a Knowledge Management Center for Illuminating the Druggable GenomeTitle Here (U54) RFA-RM-13-011
PI Name Institution Name Title
MA'AYAN, AVI ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI Mount Sinais Knowledge Management Center for Illuminating the Druggable Genome
OPREA, TUDOR I UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR Illuminating the Druggable Genome Knowledge Management Center (IDG KMC)

 

Adaptation of Scalable Technologies to Illuminate the Druggable Genome (U01) RFA-RM-13-010
PI Name Institution Name Title

FINKBEINER, STEVEN M.

J. DAVID GLADSTONE INSTITUTES Physical Exam of Human Neurons to Identify Functions of the Druggable Genome
JOHNSON, GARY L. UNIV OF NORTH CAROLINA CHAPEL HILL Activation and Regulation of the Understudied Kinome Using MIB/MS Technology

MCMANUS, MICHAEL T.

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Unlocking the Hidden Kinome
QIN, JUN BAYLOR COLLEGE OF MEDICINE Signaling Networks of Nuclear Receptor Transcriptional Crosstalk in Lung Cancer
ROTH, BRYAN L (contact)
SHOICHET, BRIAN K.
UNIV OF NORTH CAROLINA CHAPEL HILL Scalable technologies for illuminating the druggable GPCR-ome
TOMITA, SUSUMU YALE UNIVERSITY Identify functional modulators of ionotropic neurotransmitter receptors in brain
YEH, JING-RUEY JOANNA (contact)
KOKEL, DAVID
MASSACHUSETTS GENERAL HOSPITAL Scalable in vivo tools for annotating and manipulating the druggable genome

 

This page last reviewed on September 10, 2019