4D Nucleome (logo)

Program Snapshot

The goal of the Common Fund’s 4D Nucleome (4DN) program is to study the three-dimensional organization of the nucleus in space and time (the 4th dimension). The nucleus of a cell contains DNA, the genetic “blueprint” that encodes all of the genes a living organism uses to produce proteins needed to carry out life-sustaining cellular functions. Scientists know that how the information in the nucleus organized, stored, and unpackaged are all important to basic human health and we are only starting to learn how changes in this organization can lead to the development of different diseases, such as cancer or our response to infectious agents like viruses.

The 4DN program has generated a variety of tools and resources so scientists can continue to learn about the importance of nuclear organization. Program deliverables currently available through the public 4DN Portal include nearly 2000 datasets from hundreds of experiments, 52 software packages and 23 protocols and reagents for researchers to use.

Pending availability of funds, the 4DN program will continue to a second stage of funding starting in 2020. The first stage of the 4DN program focused on developing ways to determine the 3D architecture of DNA in the nucleus. Stage two of the 4DN program will focus on determining what the biological meaning of this architecture is, how the organization may change in different diseases, and how we can use this information to improve human health.



This page last reviewed on July 22, 2019