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Funded Research

Notice of Special Interest (NOSI): Availability of Administrative Supplements to Accelerate Dissemination of Emerging Glycoscience Tools through Collaborations Between Developers and Early Adopters NOT-RM-20-003
PI NameInstitution NameTitle
ATKINSON, CARLMEDICAL UNIVERSITY OF SOUTH CAROLINAComplement-driven innate and adaptive autoreactivity in lung transplantation
CHU, JAIMEICAHN SCHOOL OF MEDICINE AT MOUNT SINAIMannose metabolism as a regulator of hepatic stellate cell activation and fibrosis
MOHAMED, ABEER MUNIVERSITY OF ILLINOIS AT CHICAGOShedding of Endothelial Glycocalyx in Morbidly Obese Patients
NIU, JIABOSTON COLLEGEDevelopment of Compact CRISPR Editors for Multiplexed Editing of Complex Gene Networks
PETERSEN, CHRISTINE A (contact)
GOMES-SOLECKI, MARIA
UNIVERSITY OF IOWAField trial and modeling of transmission blocking vaccine to prevent Lyme disease
SCHNABL, BERND G. (contact)
ECKMANN, LARS
UNIVERSITY OF CALIFORNIA, SAN DIEGOSan Diego Digestive Diseases Research Center
SHAPIRO, VIRGINIA SMITHMAYO CLINIC ROCHESTERST8Sia6 expression on tumors inhibits the immune response
SHARMA, KUMARUNIVERSITY OF TEXAS HLTH SCIENCE CENTERSpatial Metabolomics for Human Kidneys
SMITH, LACHLAN JAMESUNIVERSITY OF PENNSYLVANIAPathogenesis and Treatment of Bone Disease in the Mucopolysaccharidoses
THURMAN, JOSHUA MUNIVERSITY OF COLORADO DENVERComplement-mediated injury of the kidney: New mechanisms and novel therapies
TIEMEYER, MICHAEL (contact)
MAZUMDER, RAJA
UNIVERSITY OF GEORGIAGlyGen Supplement: Develop automatic literature mining tool for extracting context specific glycan-protein data that will enhance the extent and quality of data in GlyGen

 

Notice of Special Interest (NOSI): Accelerate Dissemination of Emerging Glycoscience Tools through Collaborations Between Developers and Early Adopters (Admin Supp) NOT-RM-19-012
PI NameInstitution NameTitle
BLENIS, JOHNWEILL MEDICAL COLL OF CORNELL UNIVMitogenic and ocogenic regulation of ERK/RSK signaling
MINEO, CHIEKOUT SOUTHWESTERN MEDICAL CENTEREndothelial basis of obesity-induced insulin resistance 
RAJARATHNAM, KRISHNA (contact)
CHOPRA, ASHOK K
UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTOEngineered chemokines as therapeutics for bacterial infections
RUIZ, NATIVIDADOHIO STATE UNIVERSITYEnvelope Biogenesis in Gram-negative Bacteria
SCHMIDT, ERIC PETER (contact)
HERSON, PACO S
UNIVERSITY OF COLORADO DENVERTargeting circulating endothelial glycocalyx fragments to reduce septic encephalopathy
SCOTT, MELANIE JUNIVERSITY OF PITTSBURGInflammasome activation in trauma-hemorrhagic shock
SAXENA, RICHAMASSACHUSETTS GENERAL HOSPITALGenetics of chronotype and impact on metabolic disease
Novel and innovative tools to facilitate identificiation, manipulation, and analysis of glycans and their functions (U01) RFA-RM-18-036
PI NameInstitution NameTitle
BUELOW, HANNES ERICH (contact)
STEIDL, ULRICH G
ALBERT EINSTEIN COLLEGE OF MEDICINE, INC A Fluorescence-Based High-Throughput Platform for Glycotyping the Hematopoetic Cell Lineage
KOHLER, JENNIFER JUT SOUTHWESTERN MEDICAL CENTERNew Tools for Studying GlcNAc Biology
SCHNAAR, RONDALD LJOHNS HOPKINS UNIVERSITYGanglioside Interactome Toolkit
STOWELL, SEAN R (contact)
CUMMINGS, RICHARD D
EMORY UNIVERSITYIntegrating Microbial Glycan Arrays with Genomic Sequences to Study Host Microbe Interactions
WOO, CHRISTINAHARVARD UNIVERISTYTools to Facilitate Manipulation of Protein-Specific Glycosylation Stoichiometry in Cells
Innovative Adaptations to Simplify Existing technologies for Manipulation and Analysis of Glycans (U01) RFA-RM-18-037
PI NameInstitution NameTitle
DESAI, UMESH RAMANLALVIRGINIA COMMONWEALTH UNIVERSITYTool for Predicting Glycosaminoglycan Recognition of Proteins
DRAKE, RICHARD R (contact)
ANGEL, PEGGY M
MEHTA, ANAND S
MEDICAL UNIVERSITY OF SOUTH CAROLINASimplified Glycan Profiling Workflows of Captured Immune Glycoproteins and Cells
Innovative Adaptations to Simplify Existing technologies for Manipulation and Analysis of Glycans (U01) RFA-RM 17-029
PI NameInstitution NameTitle
AMSTER, I JONATHANUNIVERSITY OF GEORGIAAn Automated Platform for the CE-MS Analysis of Glycosaminoglycans
GOLDMAN, RADOSLAV (contact) 
EDWARDS, NATHAN J 
GEORGETOWN UNIVERSITYLC-MS Analysis of Site Specific Protein Glycoforms

 

Novel and innovative tools to facilitate identification, tracking, manipulation, and analysis of glycans and their functions (U01) RFA-RM 17-030
PI NameInstitution NameTitle
AI, HUIWANG UNIVERSITY OF VIRGINIABapaFPs: Genetically encoded fluorescent indicators to image live-cell nucleotide sugars
BALAGURUNATHAN, KUBERANUNIVERSITY OF UTAHManipulating Glycosaminoglycans Using Synthetic Xylosides to Regulate Angiogenesis
KIESSLING, LAURA L (contact) 
IMPERIALI, BARBARA 
MASSACHUSETTS INSTITUTE OF TECHNOLOGYDevelopment of multifunctional probes for profiling microbial glycans
LI, LINGJUN UNIVERSITY OF WISCONSIN-MADISONMULTIPLEX CHEMICAL TAGS FOR HIGH-THROUGHPUT GLYCAN AND GLYCOPEPTIDE QUANTITATION AND CHARACTERIZATION
LINSTEDT, ADAM DCARNEGIE-MELLON UNIVERSITYCell-Based Sensors and Drug-Like Moldulators Targeting ppGalNAc-Transferases
ZACHARA, NATASHA ELIZABETH JOHNS HOPKINS UNIVERSITYTuning and Tagging the O-GlcNAc Modification

 

Facile Methods and Technologies for Synthesis of Biomedically Relevant Carbohydrates (U01) RFA-RM-16-020
PI NameInstitution NameTitle
CRICH, DAVIDWAYNE STATE UNIVERSITYNovel Methods and Technologies for Synthesis of Biomedically Relevant Carbohydrates
MONTGOMERY, JOHN (contact) 
NAGORNY, PAVEL 
SHERMAN, DAVID H 
UNIVERSITY OF MICHIGANCatalytic Methods for Building Block Assembly and for Stereoselective Glycosylation
TANG, WEIPINGUNIVERSITY OF WISCONSIN-MADISONDevelop Catalytic Methods to Streamline the Assembly of Oligosaccharides
WALCZAK, MACIEJ ANDRZEJUNIVERSITY OF COLORADONew Catalytic Methods for the Synthesis of Biomedically Relevant Carbohydrates
YU, HAI (contact) 
KIESSLING, LAURA L 
LI, LEI
UNIVERSITY OF CALIFORNIA AT DAVISChemoenzymatic synthesis of bacterial polysaccharides
ZHANG, LIMING (contact) 
ZHU, JIANGLONG
UNIVERSITY OF CALIFORNIA SANTA BARBARADevelopment of novel approaches for stereoselective construction of glycosidic linkages

 

Data Integration and Analysis Tools: Accessible Resources for Integration and Analysis of Carbohydrate and Glycoconjugate Data in the Context of Comparable Gene, Protein, and Lipid Data (U01) RFA-RM-16-021
PI NameInstitution NameTitle
YORK, WILLIAM S (contact) 
MAZUMDER, RAJA
UNIVERSITY OF GEORGIAComputational and Informatics Resources and Tools for Glycoscience Research

 

Novel and Innovative Tools to Facilitate Identification, Tracking, Manipulation, and Analysis of Glycans and their Functions (U01) RFA-RM-16-022
PI NameInstitution NameTitle
GRIMES, CATHERINE LEIMKUHLERUNIVERSITY OF DELAWAREMetabolic carbohydrate cell wall probes for bacterial structure and immune recognition studies
MAHAL, LARA KNEW YORK UNIVERSITYGlycoMiR: Mapping the miRNA-glycogene interactome
RUHL, STEFAN HANS-KLAUS (contact) 
SULLAM, PAUL M.
STATE UNIVERSITY OF NEW YORK AT BUFFALOHARNESSING THE ORAL MICROBIOME TO CREATE NOVEL GLYCAN-BINDING PROBES
SHE, JIN-XIONGAUGUSTA UNIVERSITYLuminex multiplex glycan array (LMGA): a high throughput and high content platform for GBPs
WANG, XU ARIZONA STATE UNIVERSITY-TEMPE CAMPUSSequencing Glycosaminoglycans using Recognition Tunneling Nanopores
ZAIA, JOSEPH BOSTON UNIVERSITY MEDICAL CAMPUSAn open-source software suite for processing glycomics and glycoproteomics mass spectral data

 

Innovative Adaptations to Simplify Existing Technologies for Manipulation and Analysis of Glycans (U01) RFA-RM-16-023
PI NameInstitution NameTitle
REINHOLD, VERNON NYEUNIVERSITY OF NEW HAMPSHIREShaping MSn Technology for High Impact Glycan Sequencing
WOODS, ROBERT J (contact) 
YOUNG, JASMINE Y 
UNIVERSITY OF GEORGIAGlyProbity: tools to curate glycan structure pre and post deposition in the PDB
YANG, LORETTAGLYCOSENSORS AND DIAGNOSTICS, LLCAdapting multiplex microspheres to analyze glycosylation features by flow cytometry

 

Novel and Innovative Tools to Facilitate Identification, Tracking, Manipulation, and Analysis of Glycans and their Functions (R21) RFA-RM-15-008
PI NameInstitution NameTitle
AMSTER, I JONATHANUNIVERSITY OF GEORGIARapid Sequencing of Sulfated Glycans By CE-MS/MS
AZADI, PARASTOO UNIVERSITY OF GEORGIAGlycan linkage and sequence plus determination of site of glycosylation by permethylation of glycopeptides and MSn analysis in a one pot experiment
BERN, MARSHALL WAYNEPROTEIN METRICS, INC.Glycopeptide Identification with a Comprehensive Proteomics Search Engine
DRAKE, RICHARD R.
 
MEDICAL UNIVERSITY OF SOUTH CAROLINADetection and Histopathology Localization of O-Glycans and Glycosaminoglycans in Tissues
GHIRLANDA, GIOVANNA (contact) 
OZKAN, SEFIKA BANU
ARIZONA STATE UNIVERSITY-TEMPE CAMPUSNew Tools for Glycoscience: Engineering Targeted Lectins by Computer-Guided Directed Evolution
GODULA, KAMIL (contact) 
GAGNEUX, PASCAL
UNIVERSITY OF CALIFORNIA SAN DIEGOGlycan array for phenotype-driven capture and genotyping of viruses in primary isolates
HAAB, BRIAN B.VAN ANDEL RESEARCH INSTITUTEOn-chip Glycan Analysis of Clinical Specimens
HILI, RYANUNIVERSITY OF GEORGIAFunctionalized DNA as glycan recognition molecules
KOHLER, JENNIFER JUT SOUTHWESTERN MEDICAL CENTERPhotocrosslinking probes to discover glycan-dependent interactions
LI, LINGJUN UNIVERSITY OF WISCONSIN-MADISON    MassDefect-based Chemical Tags for Multiplex Glycan Quantitation
LIN, CHENGBOSTON UNIVERSITY MEDICAL CAMPUSCharacterization of glycan isomers by trapped ion mobility spectrometry-electron activated dissociation tandem mass spectrometry
LINSTEDT, ADAM DCARNEGIE-MELLON UNIVERSITYDRUG-LIKE MODULATORS TARGETING O-GLYCOSYLATION BY GalNAc TRANSFERASE-2/3
NYCHOLAT, CORWIN MICHAELSCRIPPS RESEARCH INSTITUTEDeveloping high affinity ligands of glycan binding proteins
RANZINGER, RENE (contact) 
AOKI, KAZUHIRO
UNIVERSITY OF GEORGIADevelopment of high-throughput workflow for glycosphingolipid analysis and annotation
SONG, XUEZHENGEMORY UNIVERSITYNext generation glycan microarray (NGGM) enabled by next generation sequencing (NGS) and DNA-coded glycan library
TEYTON, LUCSCRIPPS RESEARCH INSTITUTEProduction of high affinity anti-glycan and anti-glycolipid antibodies
ZENG, YONGUNIVERSITY OF KANSAS LAWRENCEIntegrated Digital Microfluidic Platforms for Next-Generation Glycomics

 

Facile Methods and Technologies for Synthesis of Biomedically Relevant Carbohydrates (U01) RFA-RM-15-007
PI NameInstitution NameTitle
BENNETT, CLAY SAMUELTUFTS UNIVERSITY MEDFORDReagent Control for Stereoselective Glycosylation Reactions
BOONS, GEERT-JANUNIVERSITY OF GEORGIAStreamlining the chemoenzymatic synthesis of asymmetrical glycans of biological importance
BRICHACEK, MATTHEW PAULUNIVERSITY OF MAINE ORONOTransformative Methods for the Solid Phase Synthesis of Oligosaccharides
CHEN, XI (contact) 
WANG, PENG GEORGE
UNIVERSITY OF CALIFORNIA AT DAVISFacile chemoenzymatic synthesis and purification of glycolipids
DEMCHENKO, ALEXEI V (contact) 
DE MEO, CRISTINA  
STINE, KEITH J.
UNIVERSITY OF MISSOURI-ST. LOUISRefinement and implementation of the automated oligosaccharide synthesizer
NGUYEN, HIEN MUNIVERSITY OF IOWACatalytic Methods for Stereoselective 1,2-Cis Glycosylation

 

Novel and Innovative Tools to Facilitate Identification, Tracking, Manipulation, and Analysis of Glycans and their Functions (U01) RFA-RM-15-009
PI NameInstitution NameTitle
BERTOZZI, CAROLYN R (contact) 
PITTERI, SHARON 
STANFORD UNIVERSITYMaking glycoproteomics via mass spectrometry more accessible to the greater scientific community
JU, TONGZHONGEMORY UNIVERSITYNovel Technologies for Quantitative O-glycomics and Amplification/Preparation of Cellular O-Glycans
WOODS, ROBERT J (contact) 
FOLEY, B. LACHELE
UNIVERSITY OF GEORGIATools to enable non-specialists to model glycoconjugates and glycan-protein interactions

 

Data Integration and Analysis Tools: Accessible Resources for Integration and Analysis of Carbohydrate and Glycoconjugate Structural, Analytical, and Interaction Data in the Context of Comparable Gene, Protein, and Lipid Data (R34) RFA-RM-14-012
PI NameInstitution NameTitle
MAZUMDER, RAJAGEORGE WASHINGTON UNIVERSITYGlycoCentral: Glycobiology data and tool integration with genes, proteins and lipids
YORK, WILLIAM S.UNIVERSITY OF GEORGIAglySpace: an integrated infrastructure for Glycoinformatics

 

Novel and Innovative Tools to Facilitate Identification, Tracking, Manipulation, and Analysis of Glycans and their Functions (U01) RFA-RM-14-013
PI NameInstitution NameTitle
CUMMINGS, RICHARD D (contact) 
MERNAUGH, RAYMOND L
BETH ISRAEL DEACONESS MEDICAL CENTERSmart Anti-Glycan Reagents to Generate the Human Glycome Atlas
VARKI, AJIT PUNIVERSITY OF CALIFORNIA SAN DIEGOSialoglycan-Recognizing Probes for Defining Sialoglycomes in Biological Systems

 

Novel and Innovative Tools to Facilitate Identification, Tracking, Manipulation, and Analysis of Glycans and their Functions (R21) RFA-RM-14-014
PI NameInstitution NameTitle
BERTOZZI, CAROLYN RSTANFORD UNIVERSITYRevolutionizing the detection of O-GlcNAc
COBB, BRIAN A (contact) 
ABBOTT, DEREK W
CASE WESTERN RESERVE UNIVERSITYGlycome-Enhanced KnockOut (GEKO) Technology
COON, JOSHUA JUNIVERSITY OF WISCONSIN-MADISONActivated-Ion Negative Electron Transfer Dissociation For High-Throughput Glycoproteomics
NOVOTNY, MILOSINDIANA UNIVERSITYNew Chromatographic Technologies for Resolving Carbohydrate Isomers
RUHL, STEFAN HANS-KLAUS (contact) 
SULLAM, PAUL M.
STATE UNIVERSITY OF NEW YORK AT BUFFALOMINING THE ORAL MICROBIOME FOR NOVEL GLYCAN-BINDING MOLECULES
SHE, JIN-XIONGGEORGIA REGENTS RESEARCH INSTITUTE INCMultiplex Luminex glycan array for large scale analyses of glycan-binding proteins
STOJANOVIC, MILAN NCOLUMBIA UNIVERSITY HEALTH SCIENCESAutomated Microfluidic Selection of Aptamers against Carbohydrates
TANG, KEQIBATTELLE PACIFIC NORTHWEST LABORATORIESA hybrid IMS-MS platform for ultrasensitive and high resolution glycan analysis
WANG, LIANCHUNUNIVERSITY OF GEORGIAUsing CRISPR-Cas9 technology to develop a mutant cell library for heparan sulfate structure-function study
WANG, XUARIZONA STATE UNIVERSITY-TEMPE CAMPUSSingle Molecule Sequencing of Glycosaminoglycans using Recognition Tunneling Nanopores
WEST, CHRISTOPHER M. (contact) 
TARLETON, RICK L 
WELLS, LANCE
UNIVERSITY OF GEORGIAEnabling tools for protists pathogen glycobiology
ZACHARA, NATASHA ELIZABETHJOHNS HOPKINS UNIVERSITYChemical Genetic Tools for the Spatial and Temporal Modulation of O-GlcNAcylation
ZAIA, JOSEPHBOSTON UNIVERSITYSoftware for automated interpretation of heparan sulfate tandem mass spectra

 

Facile Methods and Technologies for Synthesis of Biomedically Relevant Carbohydrates (U01) RFA-RM-14-015
PI NameInstitution NameTitle
CHAIKOF, ELLIOT (contact) 
CUMMINGS, RICHARD D
BETH ISRAEL DEACONESS MEDICAL CENTERFacile Synthesis of Glycosulfopeptides and Related Bioconjugates
HSIEH-WILSON, LINDA C (contact) 
HUANG, XUEFEI
CALIFORNIA INSTITUTE OF TECHNOLOGYExpedited Synthesis of Glycosaminoglycans Containing Defined Sulfation Domains
JACOBSEN, ERIC NHARVARD COLLEGESmall-Molecule Catalysts for the Stereoselective Synthesis of Oligosaccharides
POHL, NICOLA LINDIANA UNIVERSITYSugar Building Blocks and Automated Synthesis of Biomedically-Relevant Glycans
SONG, XUEZHENG (contact) 
REINHOLD, VERNON NYE
EMORY UNIVERSITYFacile Chemical Methods for Reverse Synthesis and Large Scale Production of Biomedically Relevant Glycan Libraries
WANG, PENG GEORGE (contact) 
LI, LEI
GEORGIA STATE UNIVERSITYFacile Synthesis of O-Glycans and O-Glycopeptides

This page last reviewed on January 30, 2024