Funded Research
*Advisory Committee to the NIH Director Working Group Findings
2019 NIH Director's Transformative Research Award (R01) - RFA-RM-18-009
| PI Name | Institution Name | Title |
|---|---|---|
| BREM, RACHEL BETH (contact); BAUTISTA, DIANA MICHELE; ELLERBY, LISA M; VERDIN, ERIC M
|
BUCK INSTITUTE FOR RESEARCH ON AGING
|
Genetic Dissection of Trait Variation Between Long-Diverged Mouse Species
|
| CHAIT, BRIAN T
|
ROCKEFELLER UNIVERSITY
|
Development of Next Generation Mass Spectrometric Instrumentation for Proteomics
|
| DEDON, PETER C (contact); ALM, ERIC JOHN
|
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
|
Epigenetics of the Human Gut Microbiome
|
| DENNY, CHRISTINE ANN (contact); RAMIREZ, STEVE
|
NEW YORK STATE PSYCHIATRIC INSTITUTE
|
Single-Cell and Target-Specific Resolution of Multiple Memories Across the Brain
|
| GEISSMANN, FREDERIC
|
SLOAN-KETTERING INST CAN RESEARCH
|
Role of Microglia Somatic Variants in Neurodegenerative Diseases
|
| GLADYSHEV, VADIM N
|
BRIGHAM AND WOMEN'S HOSPITAL
|
Unbiased Identification of Interventions that Extend Lifespan
|
| JARVIS, ERICH D
|
ROCKEFELLER UNIVERSITY
|
Neuroengineering a Robust Vocal Learning Phenotype in Mice as a Model for Treating Communication Disorders
|
| RAJ, ARJUN (contact); JAIN, RAJAN
|
UNIVERSITY OF PENNSYLVANIA
|
Decoding the Bridges and Barriers to Cellular Reprogramming and Lineage Identity
|
| SHEPHERD, JASON D (contact); CAMPBELL, EDWARD M; GALLAGHER, THOMAS MILLER
|
UNIVERSITY OF UTAH
|
Virus-Like Intercellular Communication in the Nervous System
|
2018 NIH Director's Transformative Research Award (R01) - RFA-RM-17-007
| PI Name | Institution Name | Title |
|---|---|---|
| ALBEANU, DINU FLORENTIN (contact); KOULAKOV, ALEXEI
|
COLD SPRING HARBOR LABORATORY
|
A High-Throughput Sequencing and Imaging Approach to Understand the Functional Basis of Olfaction
|
| DEISSEROTH, KARL A (contact); BRUNET, ANNE
|
STANFORD UNIVERSITY
|
Brain-Wide Screen for a Neural Pacemaker of Aging
|
| KODADEK, THOMAS J
|
SCRIPPS FLORIDA
|
Phenotypic Screening Using DNA-Encoded Libraries
|
| KORNBERG, ROGER D
|
STANFORD UNIVERSITY
|
Three-Dimensional Structure of Eukaryote Chromosomes
|
| LEE, RICHARD T
|
HARVARD UNIVERSITY
|
Novel Age-Dependent DNA Modifications
|
| PAYNE, AIMEE S (contact); MASON, NICOLA J
|
UNIVERSITY OF PENNSYLVANIA
|
Translating Cellular Immunotherapies for Autoimmunity to Canine Clinical Trials
|
| PERRIMON, NORBERT (contact); CARR, STEVEN A; MCMAHON, ANDREW P; TING, ALICE Y
|
HARVARD MEDICAL SCHOOL
|
Mapping Protein Communication Between Organs in Homeostasis and Disease
|
| SCHIFF, STEVEN J
|
PENNSYLVANIA STATE UNIV HERSHEY MED CTR
|
Predictive Personalized Public Health (P3H): A Novel Paradigm to Treat Infectious Disease
|
| STRICK, PETER
|
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
|
The Neural Basis of the Brain-Body Connection
|
| TRAVER, DAVID (contact); BAO, ZHIRONG ; HUISKEN, JAN
|
UNIVERSITY OF CALIFORNIA, SAN DIEGO
|
An Integrative Cellular Blueprint of Vertebrate Tissue Development
|
2017 NIH Director's Transformative Research Award (R01) - RFA-RM-16-007
2016 NIH Director's Transformative Research Award (R01) - RFA-RM-15-005
| PI Name | Institution Name | Title |
|---|---|---|
| CHOUDHARY, AMIT (contact) SECOR, STEPHEN M WAGNER, BRIDGET K
|
BROAD INSTITUTE, INC.
|
Leveraging Snakes Extreme Physiology to Modulate Human Beta-Cell Function
|
| HEDRICK, STEPHEN M (contact) BIER, ETHAN GOLDRATH, ANANDA W
|
UNIVERSITY OF CALIFORNIA SAN DIEGO
|
Mutagenic Chain Reaction-Facilitated Immunotherapy
|
| LESSER, CAMMIE (contact) GARRETT, WENDY S. LEONG, JOHN M
|
MASSACHUSETTS GENERAL HOSPITAL
|
Designer Probiotics for the Treatment of Intestinal Infection and Inflammation
|
| LESTER, HENRY A.
|
CALIFORNIA INSTITUTE OF TECHNOLOGY
|
Fluorescent Biosensors for Subcellular Pharmacokinetics
|
| MAGGERT, KEITH A
|
UNIVERSITY OF ARIZONA
|
Induced Transgenerational Inheritance without Epigenetics
|
| RANGANATHAN, RAMA
|
UT SOUTHWESTERN MEDICAL CENTER
|
Seeing Protein Mechanics: The Link between Molecular Structure, Function, and Evolution
|
| RIENSTRA, CHAD M (contact) MORRISSEY, JAMES H. TAJKHORSHID, EMAD
|
UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN
|
Toolkit for High-Resolution Structure and Dynamics of Functional Lipids
|
| WOOLLEY, CATHERINE S
|
NORTHWESTERN UNIVERSITY
|
New Tools to Study Neurosteroid Estrogens
|
| WU, CHAO-TING
|
HARVARD MEDICAL SCHOOL
|
Culling the Human Genome of Disease Variants Using Ultraconserved Elements
|
| YANKNER, BRUCE A (contact) CHURCH, GEORGE M
|
HARVARD MEDICAL SCHOOL
|
Exploring a Novel Paradigm of Schizophrenia and Bipolar Disorder
|
| ZHANG, XIAOJING
|
DARTMOUTH COLLEGE
|
Implantable Cardiac Power Generation Using Flexible 3D Porous Thin Films
|
| ZHUANG, XIAOWEI (contact) DULAC, CATHERINE G
|
HARVARD UNIVERSITY
|
In Situ Transcriptome Imaging in Single Cells
|
2015 NIH Director's Transformative Research Award (R01) - RFA-RM-14-003
| PI Name | Institution Name | Title |
|---|---|---|
| ALLBRITTON, NANCY L. (contact) BULTMAN, SCOTT J GOMEZ, SHAWN MICHAEL MAGNESS, SCOTT T
|
UNIV OF NORTH CAROLINA CHAPEL HILL
|
Development of Human Intestinal Simulacra
|
| BADAWI, RAMSEY D. (contact) CHERRY, SIMON R
|
UNIVERSITY OF CALIFORNIA AT DAVIS
|
EXPLORER: Changing the Molecular Imaging Paradigm with Total Body PET
|
| BARKER, THOMAS HARRISON
|
GEORGIA INSTITUTE OF TECHNOLOGY
|
Mechanosensors that Detect and Treat Lung Fibrosis
|
| DOLINOY, DANA
|
UNIVERSITY OF MICHIGAN
|
Development of piRNAs for Target-Specific Methylation
|
| HETZER, MARTIN W
|
SALK INSTITUTE FOR BIOLOGICAL STUDIES
|
The Role of Long-Lived Proteins in the Survival of Nerve Cells
|
| HOTOPP, JULIE
|
UNIVERSITY OF MARYLAND BALTIMORE
|
Extent and Significance of Bacterial DNA Integrations in the Human Cancer Genome
|
| TAVAZOIE, SAEED F
|
COLUMBIA UNIVERSITY HEALTH SCIENCES
|
Massively Parallel Mapping of All Molecular Interactions in a Single Tube
|
| ZHANG, FENG
|
BROAD INSTITUTE, INC.
|
Massively-Parallel Functional Interrogation of Psychiatric Genetics
|
2014 NIH Director's Transformative Research Award (R01) - RFA-RM-13-008
| PI Name | Institution Name | Title |
|---|---|---|
| ARNOLD, DONALD B (contact) FRASER, SCOTT E KESSELMAN, CARL
|
UNIVERSITY OF SOUTHERN CALIFORNIA
|
Dynamic Mapping of the Complete Synaptome Using Recombinant Probes
|
| GIMELBRANT, ALEXANDER
|
DANA-FARBER CANCER INSTITUTE
|
Mechanism and Function of Autosomal Analog of X Inactivation
|
| JAIN, SANJAY
|
JOHNS HOPKINS UNIVERSITY
|
Novel Imaging Tracers for Rapid and Noninvasive Assessment of Bacterial Infection
|
| KIM, DENNIS H (contact) SCHROEDER, FRANK CLEMENS
|
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
|
Antimicrobial Discovery from Metabolomics of Nematode Pathogen Interactions
|
| LIM, WENDELL A
|
UNIVERSITY OF CALIFORNIA SAN FRANCISCO
|
Redesigning the T cell: Using Synthetic Biology to Engineer Therapeutic Cells
|
| MCMANUS, MICHAEL T
|
UNIVERSITY OF CALIFORNIA SAN FRANCISCO
|
Tracing Cell Lineages
|
| MOCARSKI, EDWARD S.
|
EMORY UNIVERSITY
|
Innate Activation and Death Signals in Health and Disease
|
| RAFII, SHAHIN
|
WEILL MEDICAL COLL OF CORNELL UNIV
|
Deciphering Molecular Determinants of Vascular Heterogeneity for Organ Repair
|
| SMITH, STEPHEN J (contact) BURNS, RANDAL
|
ALLEN INSTITUTE OF BRAIN SCIENCE
|
Synaptomes of Mouse and Man
|
2013 NIH Director's Transformative Research Award (R01) - RFA-RM-12-017
| PI Name | Institution Name | Title |
|---|---|---|
| CARNES, MOLLY L (contact) DEVINE, PATRICIA G FORD, CECILIA E
|
UNIVERSITY OF WISCONSIN-MADISON
|
Exploring the Science of Scientific Review
|
| KORDING, KONRAD P. (contact) BOYDEN, EDWARD S. CHURCH, GEORGE M
|
REHABILITATION INSTITUTE OF CHICAGO
|
Recording Neural Activities onto DNA
|
| MANDEL, GAIL (contact) ADELMAN, JOHN P BREHM, PAUL ROSENTHAL, JOSHUA J.C.
|
OREGON HEALTH AND SCI UNIVERSITY
|
Site-Directed RNA Editing: A New Method to Correct Disease Causing Mutations
|
| OCHOA, AUGUSTO C
|
LOUISIANA STATE UNIV HSC NEW ORLEANS
|
Metabolic Approaches to Treat Severe Viral and Inflammatory Diseases
|
| RELMAN, DAVID ARNOLD (contact) HOLMES, SUSAN P
|
PALO ALTO INSTITUTE FOR RES & EDU, INC.
|
Predicting Resilience in the Human Microbiome
|
| TING, ALICE Y
|
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
|
Spatially-Resolved Proteomic Mapping of Living Cells
|
| WANG, LIHONG
|
WASHINGTON UNIVERSITY
|
In Vivo Imaging of Single Circulating Cells
|
| WYSSCORAY, TONY (contact) RANDO, THOMAS A.
|
PALO ALTO INSTITUTE FOR RES & EDU, INC.
|
A New Muscle-Brain Axis Underlying the Cognitive Benefits of Physical Activity
|
| YANNOPOULOS, DEMETRI
|
UNIVERSITY OF MINNESOTA
|
Reperfusion Injury Protection Strategies during Basic Life Support
|
| YIN, PENG
|
HARVARD UNIVERSITY (MEDICAL SCHOOL)
|
Super-Resolution Imaging via Programmable Autonomous Blinking
|
2012 NIH Director's Transformative Research Award (R01) - RFA-RM-11-006
| PI Name | Institution Name | Title |
|---|---|---|
| ABELIOVICH, ASA
|
COLUMBIA UNIVERSITY HEALTH SCIENCES
|
Generation and Integration of New CNS Neurons by In Vivo Directed Conversion
|
| ALLISON, DAVID B
|
UNIVERSITY OF ALABAMA BIRMINGHAM
|
Energetics, Disparities, & Lifespan: A Unified Hypothesis
|
| ALTSHULER, DAVID (contact) COWAN, CHAD ALBERT
|
THE BROAD INSTITUTE, INC.
|
Isogenic Human Pluripotent Stem Cell-Based Models of Human Disease Mutations
|
| BARRES, BEN A
|
STANFORD UNIVERSITY
|
An Astrocytic Basis for Humanity
|
| BLAU, HELEN M
|
STANFORD UNIVERSITY
|
Telomere Extension Using Nucleoside-Modified mRNA and Exosomes as a Novel Therape
|
| BROWN, EMERY N. (contact) BOYDEN, EDWARD S. SOLT, KEN WILSON, MATTHEW A.
|
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
|
Redesigning General Anesthesia
|
| CHRISTMAN, KAREN L (contact) GIANNESCHI, NATHAN CLAUDE
|
UNIVERSITY OF CALIFORNIA SAN DIEGO
|
Autonomously Assembling Nanomaterial Scaffolds for Treating Myocardial Infarction
|
| DARNELL, ROBERT B
|
THE ROCKEFELLER UNIVERSITY
|
Mapping the Mechanisms of Protein Synthesis-Dependent Synaptic Plasticity
|
| DEISSEROTH, KARL ALEXANDER
|
STANFORD UNIVERSITY
|
CLARITY: Fully-Assembled Biology
|
| GEREAU, ROBERT W (contact) BRUCHAS, MICHAEL R ROGERS, JOHN
|
WASHINGTON UNIVERSITY
|
Multimodal Biocompatible MicroLED Devices for Diverse Neuroscience Applications
|
| GLASS, CHRISTOPHER K
|
UNIVERSITY OF CALIFORNIA SAN DIEGO
|
Enhancer Therapy
|
| MARASCO, PAUL
|
CLEVELAND VA MEDICAL RESEARCH/ED/FDN
|
Restoring Upper Limb Movement Sense to Amputees; A Move towards Natural Control of Prosthetic Limbs
|
| NEWMAN, DIANNE K
|
CALIFORNIA INSTITUTE OF TECHNOLOGY
|
Geobiological Approaches to Understanding Pulmonary Infections In Situ
|
| SHEA, LONNIE D (contact) BACKMAN, VADIM
|
NORTHWESTERN UNIVERSITY
|
An In Vivo Metastasis Sensor
|
| SHEVKOPLYAS, SERGEY S
|
TULANE UNIVERSITY OF LOUISIANA
|
Eliminating Mediators of Toxicity from Stored Blood
|
| STOJANOVIC, MILAN N (contact) YAN, HAO
|
COLUMBIA UNIVERSITY HEALTH SCIENCES
|
Theranostic Nano-objects: Basic Principles and Initial Applications
|
| TUSCHL, THOMAS (contact) OHLER, UWE PATEL, DINSHAW J
|
THE ROCKEFELLER UNIVERSITY
|
Posttranscriptional Regulation by mRNA-Binding Shuttling and Transport Proteins
|
| WEINER, HOWARD L
|
BRIGHAM AND WOMEN'S HOSPITAL, INC
|
Role of the Innate Immune System in Aging and Development of Alzheimer's Disease
|
| WISNIEWSKI, NATALIE ANN (contact) MCSHANE, MIKE
|
PROFUSA, INC.
|
Implantable Multi-Analyte Sensors for the Continuous Monitoring of Body Chemistries
|
| WUCHERPFENNIG, KAI W (contact) GOTTSCHALK, STEPHEN
|
DANA-FARBER CANCER INSTITUTE
|
Reprogramming of T cells for the Treatment of Melanoma
|
2011 NIH Director's Transformative Research Award (R01) - RFA-RM-10-010
| PI Name | Institution Name | Title |
|---|---|---|
| BEN-YAKAR, ADELA (contact) PIERCE-SHIMOMURA, JONATHAN T
|
UNIVERSITY OF TEXAS AUSTIN
|
High-Speed Opto-Fluidics to Screen Entire Nervous System in Aging and Disease
|
| BOAHEN, KWABENA
|
STANFORD UNIVERSITY
|
Fully Implantable and Programmable Spike-based Codecs for Neuroprosthetics
|
| GAGE, FRED H
|
SALK INSTITUTE FOR BIOLOGICAL STUDIES
|
Single-Cell Approaches to Reveal How Jumping Genes Individualize Neural Circuits
|
| HARTUNG, THOMAS
|
JOHNS HOPKINS UNIVERSITY
|
Mapping the Human Toxome by Systems Toxicology |
| HONKANEN, RICHARD E
|
UNIVERSITY OF SOUTH ALABAMA
|
Methods to Enable Cholesterol Catabolism in Human Monocyte Derived Macrophages |
| JASANOFF, ALAN
|
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
|
Noninvasive Imaging-Based Electrophysiology Using Microelectronic Devices |
| KUPPER, THOMAS S CLARK, RACHAEL ANN |
BRIGHAM AND WOMEN'S HOSPITAL
|
Vaccination to Generate Protective Tissue Resident T Cells
|
| LECKMAN, JAMES F (contact) WEXLER, BRUCE E.
|
YALE UNIVERSITY
|
Integrated Brain, Body and Social Intervention for ADHD
|
| LICHTMAN, JEFF W (contact) MEISTER, MARKUS SANES, JOSHUA R SEUNG, H SEBASTIAN
|
HARVARD UNIVERSITY
|
High Resolution Connectomics of Mammalian Neural Circuits |
| LIN, HENING (contact) CERIONE, RICHARD A WEISS, ROBERT S
|
CORNELL UNIVERSITY ITHACA
|
Succinylation and Malonylation as Novel Protein Modifications in Cancer
|
| MCDEVITT, TODD C
|
GEORGIA INSTITUTE OF TECHNOLOGY
|
Stem Cell Morphogen Delivery via Engineered Biomaterials |
| MOOTHA, VAMSI KRISHNA
|
MASSACHUSETTS GENERAL HOSPITAL
|
Molecular Prostheses for Mitochondrial Disorders
|
| NIE, SHUMING (contact) SINGHAL, SUNIL
|
EMORY UNIVERSITY
|
Contrast-Enhanced and Image-Guided Surgery of Lung Cancer
|
| NOLTA, JAN A
|
UNIVERSITY OF CALIFORNIA DAVIS
|
Direct Cell to Cell Transfer of microRNA for Tissue Repair |
| PAPAVASILIOU, F NINA
|
ROCKEFELLER UNIVERSITY
|
Building Novel Vaccines on a Borrowed Coat
|
| PUGLISI, JOSEPH D
|
STANFORD UNIVERSITY
|
Single Molecule Translational Profiling |
| ROSS, MARGARET ELIZABETH (contact) MASON, CHRISTOPHER EDWARD
|
WEILL MEDICAL COLLEGE OF CORNELL UNIV
|
Epigenome Interactions in Complex Neurogenetic Disorders
|
2010 NIH Director's Transformative Research Award (R01) - RFA-RM-09-022
2009 NIH Director's Transformative Research Award (R01) - RFA-RM-08-029
This page last reviewed on October 8, 2019