Funded Research
*Advisory Committee to the NIH Director Working Group Findings
2019 NIH Director's Transformative Research Award (R01) - RFA-RM-18-009
PI Name | Institution Name | Title |
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BREM, RACHEL BETH (contact); BAUTISTA, DIANA MICHELE; ELLERBY, LISA M; VERDIN, ERIC M
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BUCK INSTITUTE FOR RESEARCH ON AGING
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Genetic Dissection of Trait Variation Between Long-Diverged Mouse Species
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CHAIT, BRIAN T
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ROCKEFELLER UNIVERSITY
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Development of Next Generation Mass Spectrometric Instrumentation for Proteomics
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DEDON, PETER C (contact); ALM, ERIC JOHN
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MASSACHUSETTS INSTITUTE OF TECHNOLOGY
|
Epigenetics of the Human Gut Microbiome
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DENNY, CHRISTINE ANN (contact); RAMIREZ, STEVE
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NEW YORK STATE PSYCHIATRIC INSTITUTE
|
Single-Cell and Target-Specific Resolution of Multiple Memories Across the Brain
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GEISSMANN, FREDERIC
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SLOAN-KETTERING INST CAN RESEARCH
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Role of Microglia Somatic Variants in Neurodegenerative Diseases
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GLADYSHEV, VADIM N
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BRIGHAM AND WOMEN'S HOSPITAL
|
Unbiased Identification of Interventions that Extend Lifespan
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JARVIS, ERICH D
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ROCKEFELLER UNIVERSITY
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Neuroengineering a Robust Vocal Learning Phenotype in Mice as a Model for Treating Communication Disorders
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RAJ, ARJUN (contact); JAIN, RAJAN
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UNIVERSITY OF PENNSYLVANIA
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Decoding the Bridges and Barriers to Cellular Reprogramming and Lineage Identity
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SHEPHERD, JASON D (contact); CAMPBELL, EDWARD M; GALLAGHER, THOMAS MILLER
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UNIVERSITY OF UTAH
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Virus-Like Intercellular Communication in the Nervous System
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2018 NIH Director's Transformative Research Award (R01) - RFA-RM-17-007
PI Name | Institution Name | Title |
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ALBEANU, DINU FLORENTIN (contact); KOULAKOV, ALEXEI
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COLD SPRING HARBOR LABORATORY
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A High-Throughput Sequencing and Imaging Approach to Understand the Functional Basis of Olfaction
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DEISSEROTH, KARL A (contact); BRUNET, ANNE
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STANFORD UNIVERSITY
|
Brain-Wide Screen for a Neural Pacemaker of Aging
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KODADEK, THOMAS J
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SCRIPPS FLORIDA
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Phenotypic Screening Using DNA-Encoded Libraries
|
KORNBERG, ROGER D
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STANFORD UNIVERSITY
|
Three-Dimensional Structure of Eukaryote Chromosomes
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LEE, RICHARD T
|
HARVARD UNIVERSITY
|
Novel Age-Dependent DNA Modifications
|
PAYNE, AIMEE S (contact); MASON, NICOLA J
|
UNIVERSITY OF PENNSYLVANIA
|
Translating Cellular Immunotherapies for Autoimmunity to Canine Clinical Trials
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PERRIMON, NORBERT (contact); CARR, STEVEN A; MCMAHON, ANDREW P; TING, ALICE Y
|
HARVARD MEDICAL SCHOOL
|
Mapping Protein Communication Between Organs in Homeostasis and Disease
|
SCHIFF, STEVEN J
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PENNSYLVANIA STATE UNIV HERSHEY MED CTR
|
Predictive Personalized Public Health (P3H): A Novel Paradigm to Treat Infectious Disease
|
STRICK, PETER
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UNIVERSITY OF PITTSBURGH AT PITTSBURGH
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The Neural Basis of the Brain-Body Connection
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TRAVER, DAVID (contact); BAO, ZHIRONG ; HUISKEN, JAN
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UNIVERSITY OF CALIFORNIA, SAN DIEGO
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An Integrative Cellular Blueprint of Vertebrate Tissue Development
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2017 NIH Director's Transformative Research Award (R01) - RFA-RM-16-007
2016 NIH Director's Transformative Research Award (R01) - RFA-RM-15-005
PI Name | Institution Name | Title |
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CHOUDHARY, AMIT (contact) SECOR, STEPHEN M WAGNER, BRIDGET K
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BROAD INSTITUTE, INC.
|
Leveraging Snakes Extreme Physiology to Modulate Human Beta-Cell Function
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HEDRICK, STEPHEN M (contact) BIER, ETHAN GOLDRATH, ANANDA W
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UNIVERSITY OF CALIFORNIA SAN DIEGO
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Mutagenic Chain Reaction-Facilitated Immunotherapy
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LESSER, CAMMIE (contact) GARRETT, WENDY S. LEONG, JOHN M
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MASSACHUSETTS GENERAL HOSPITAL
|
Designer Probiotics for the Treatment of Intestinal Infection and Inflammation
|
LESTER, HENRY A.
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CALIFORNIA INSTITUTE OF TECHNOLOGY
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Fluorescent Biosensors for Subcellular Pharmacokinetics
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MAGGERT, KEITH A
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UNIVERSITY OF ARIZONA
|
Induced Transgenerational Inheritance without Epigenetics
|
RANGANATHAN, RAMA
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UT SOUTHWESTERN MEDICAL CENTER
|
Seeing Protein Mechanics: The Link between Molecular Structure, Function, and Evolution
|
RIENSTRA, CHAD M (contact) MORRISSEY, JAMES H. TAJKHORSHID, EMAD
|
UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN
|
Toolkit for High-Resolution Structure and Dynamics of Functional Lipids
|
WOOLLEY, CATHERINE S
|
NORTHWESTERN UNIVERSITY
|
New Tools to Study Neurosteroid Estrogens
|
WU, CHAO-TING
|
HARVARD MEDICAL SCHOOL
|
Culling the Human Genome of Disease Variants Using Ultraconserved Elements
|
YANKNER, BRUCE A (contact) CHURCH, GEORGE M
|
HARVARD MEDICAL SCHOOL
|
Exploring a Novel Paradigm of Schizophrenia and Bipolar Disorder
|
ZHANG, XIAOJING
|
DARTMOUTH COLLEGE
|
Implantable Cardiac Power Generation Using Flexible 3D Porous Thin Films
|
ZHUANG, XIAOWEI (contact) DULAC, CATHERINE G
|
HARVARD UNIVERSITY
|
In Situ Transcriptome Imaging in Single Cells
|
2015 NIH Director's Transformative Research Award (R01) - RFA-RM-14-003
PI Name | Institution Name | Title |
---|---|---|
ALLBRITTON, NANCY L. (contact) BULTMAN, SCOTT J GOMEZ, SHAWN MICHAEL MAGNESS, SCOTT T
|
UNIV OF NORTH CAROLINA CHAPEL HILL
|
Development of Human Intestinal Simulacra
|
BADAWI, RAMSEY D. (contact) CHERRY, SIMON R
|
UNIVERSITY OF CALIFORNIA AT DAVIS
|
EXPLORER: Changing the Molecular Imaging Paradigm with Total Body PET
|
BARKER, THOMAS HARRISON
|
GEORGIA INSTITUTE OF TECHNOLOGY
|
Mechanosensors that Detect and Treat Lung Fibrosis
|
DOLINOY, DANA
|
UNIVERSITY OF MICHIGAN
|
Development of piRNAs for Target-Specific Methylation
|
HETZER, MARTIN W
|
SALK INSTITUTE FOR BIOLOGICAL STUDIES
|
The Role of Long-Lived Proteins in the Survival of Nerve Cells
|
HOTOPP, JULIE
|
UNIVERSITY OF MARYLAND BALTIMORE
|
Extent and Significance of Bacterial DNA Integrations in the Human Cancer Genome
|
TAVAZOIE, SAEED F
|
COLUMBIA UNIVERSITY HEALTH SCIENCES
|
Massively Parallel Mapping of All Molecular Interactions in a Single Tube
|
ZHANG, FENG
|
BROAD INSTITUTE, INC.
|
Massively-Parallel Functional Interrogation of Psychiatric Genetics
|
2014 NIH Director's Transformative Research Award (R01) - RFA-RM-13-008
PI Name | Institution Name | Title |
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ARNOLD, DONALD B (contact) FRASER, SCOTT E KESSELMAN, CARL
|
UNIVERSITY OF SOUTHERN CALIFORNIA
|
Dynamic Mapping of the Complete Synaptome Using Recombinant Probes
|
GIMELBRANT, ALEXANDER
|
DANA-FARBER CANCER INSTITUTE
|
Mechanism and Function of Autosomal Analog of X Inactivation
|
JAIN, SANJAY
|
JOHNS HOPKINS UNIVERSITY
|
Novel Imaging Tracers for Rapid and Noninvasive Assessment of Bacterial Infection
|
KIM, DENNIS H (contact) SCHROEDER, FRANK CLEMENS
|
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
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Antimicrobial Discovery from Metabolomics of Nematode Pathogen Interactions
|
LIM, WENDELL A
|
UNIVERSITY OF CALIFORNIA SAN FRANCISCO
|
Redesigning the T cell: Using Synthetic Biology to Engineer Therapeutic Cells
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MCMANUS, MICHAEL T
|
UNIVERSITY OF CALIFORNIA SAN FRANCISCO
|
Tracing Cell Lineages
|
MOCARSKI, EDWARD S.
|
EMORY UNIVERSITY
|
Innate Activation and Death Signals in Health and Disease
|
RAFII, SHAHIN
|
WEILL MEDICAL COLL OF CORNELL UNIV
|
Deciphering Molecular Determinants of Vascular Heterogeneity for Organ Repair
|
SMITH, STEPHEN J (contact) BURNS, RANDAL
|
ALLEN INSTITUTE OF BRAIN SCIENCE
|
Synaptomes of Mouse and Man
|
2013 NIH Director's Transformative Research Award (R01) - RFA-RM-12-017
PI Name | Institution Name | Title |
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CARNES, MOLLY L (contact) DEVINE, PATRICIA G FORD, CECILIA E
|
UNIVERSITY OF WISCONSIN-MADISON
|
Exploring the Science of Scientific Review
|
KORDING, KONRAD P. (contact) BOYDEN, EDWARD S. CHURCH, GEORGE M
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REHABILITATION INSTITUTE OF CHICAGO
|
Recording Neural Activities onto DNA
|
MANDEL, GAIL (contact) ADELMAN, JOHN P BREHM, PAUL ROSENTHAL, JOSHUA J.C.
|
OREGON HEALTH AND SCI UNIVERSITY
|
Site-Directed RNA Editing: A New Method to Correct Disease Causing Mutations
|
OCHOA, AUGUSTO C
|
LOUISIANA STATE UNIV HSC NEW ORLEANS
|
Metabolic Approaches to Treat Severe Viral and Inflammatory Diseases
|
RELMAN, DAVID ARNOLD (contact) HOLMES, SUSAN P
|
PALO ALTO INSTITUTE FOR RES & EDU, INC.
|
Predicting Resilience in the Human Microbiome
|
TING, ALICE Y
|
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
|
Spatially-Resolved Proteomic Mapping of Living Cells
|
WANG, LIHONG
|
WASHINGTON UNIVERSITY
|
In Vivo Imaging of Single Circulating Cells
|
WYSSCORAY, TONY (contact) RANDO, THOMAS A.
|
PALO ALTO INSTITUTE FOR RES & EDU, INC.
|
A New Muscle-Brain Axis Underlying the Cognitive Benefits of Physical Activity
|
YANNOPOULOS, DEMETRI
|
UNIVERSITY OF MINNESOTA
|
Reperfusion Injury Protection Strategies during Basic Life Support
|
YIN, PENG
|
HARVARD UNIVERSITY (MEDICAL SCHOOL)
|
Super-Resolution Imaging via Programmable Autonomous Blinking
|
2012 NIH Director's Transformative Research Award (R01) - RFA-RM-11-006
PI Name | Institution Name | Title |
---|---|---|
ABELIOVICH, ASA
|
COLUMBIA UNIVERSITY HEALTH SCIENCES
|
Generation and Integration of New CNS Neurons by In Vivo Directed Conversion
|
ALLISON, DAVID B
|
UNIVERSITY OF ALABAMA BIRMINGHAM
|
Energetics, Disparities, & Lifespan: A Unified Hypothesis
|
ALTSHULER, DAVID (contact) COWAN, CHAD ALBERT
|
THE BROAD INSTITUTE, INC.
|
Isogenic Human Pluripotent Stem Cell-Based Models of Human Disease Mutations
|
BARRES, BEN A
|
STANFORD UNIVERSITY
|
An Astrocytic Basis for Humanity
|
BLAU, HELEN M
|
STANFORD UNIVERSITY
|
Telomere Extension Using Nucleoside-Modified mRNA and Exosomes as a Novel Therape
|
BROWN, EMERY N. (contact) BOYDEN, EDWARD S. SOLT, KEN WILSON, MATTHEW A.
|
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
|
Redesigning General Anesthesia
|
CHRISTMAN, KAREN L (contact) GIANNESCHI, NATHAN CLAUDE
|
UNIVERSITY OF CALIFORNIA SAN DIEGO
|
Autonomously Assembling Nanomaterial Scaffolds for Treating Myocardial Infarction
|
DARNELL, ROBERT B
|
THE ROCKEFELLER UNIVERSITY
|
Mapping the Mechanisms of Protein Synthesis-Dependent Synaptic Plasticity
|
DEISSEROTH, KARL ALEXANDER
|
STANFORD UNIVERSITY
|
CLARITY: Fully-Assembled Biology
|
GEREAU, ROBERT W (contact) BRUCHAS, MICHAEL R ROGERS, JOHN
|
WASHINGTON UNIVERSITY
|
Multimodal Biocompatible MicroLED Devices for Diverse Neuroscience Applications
|
GLASS, CHRISTOPHER K
|
UNIVERSITY OF CALIFORNIA SAN DIEGO
|
Enhancer Therapy
|
MARASCO, PAUL
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CLEVELAND VA MEDICAL RESEARCH/ED/FDN
|
Restoring Upper Limb Movement Sense to Amputees; A Move towards Natural Control of Prosthetic Limbs
|
NEWMAN, DIANNE K
|
CALIFORNIA INSTITUTE OF TECHNOLOGY
|
Geobiological Approaches to Understanding Pulmonary Infections In Situ
|
SHEA, LONNIE D (contact) BACKMAN, VADIM
|
NORTHWESTERN UNIVERSITY
|
An In Vivo Metastasis Sensor
|
SHEVKOPLYAS, SERGEY S
|
TULANE UNIVERSITY OF LOUISIANA
|
Eliminating Mediators of Toxicity from Stored Blood
|
STOJANOVIC, MILAN N (contact) YAN, HAO
|
COLUMBIA UNIVERSITY HEALTH SCIENCES
|
Theranostic Nano-objects: Basic Principles and Initial Applications
|
TUSCHL, THOMAS (contact) OHLER, UWE PATEL, DINSHAW J
|
THE ROCKEFELLER UNIVERSITY
|
Posttranscriptional Regulation by mRNA-Binding Shuttling and Transport Proteins
|
WEINER, HOWARD L
|
BRIGHAM AND WOMEN'S HOSPITAL, INC
|
Role of the Innate Immune System in Aging and Development of Alzheimer's Disease
|
WISNIEWSKI, NATALIE ANN (contact) MCSHANE, MIKE
|
PROFUSA, INC.
|
Implantable Multi-Analyte Sensors for the Continuous Monitoring of Body Chemistries
|
WUCHERPFENNIG, KAI W (contact) GOTTSCHALK, STEPHEN
|
DANA-FARBER CANCER INSTITUTE
|
Reprogramming of T cells for the Treatment of Melanoma
|
2011 NIH Director's Transformative Research Award (R01) - RFA-RM-10-010
PI Name | Institution Name | Title |
---|---|---|
BEN-YAKAR, ADELA (contact) PIERCE-SHIMOMURA, JONATHAN T
|
UNIVERSITY OF TEXAS AUSTIN
|
High-Speed Opto-Fluidics to Screen Entire Nervous System in Aging and Disease
|
BOAHEN, KWABENA
|
STANFORD UNIVERSITY
|
Fully Implantable and Programmable Spike-based Codecs for Neuroprosthetics
|
GAGE, FRED H
|
SALK INSTITUTE FOR BIOLOGICAL STUDIES
|
Single-Cell Approaches to Reveal How Jumping Genes Individualize Neural Circuits
|
HARTUNG, THOMAS
|
JOHNS HOPKINS UNIVERSITY
|
Mapping the Human Toxome by Systems Toxicology |
HONKANEN, RICHARD E
|
UNIVERSITY OF SOUTH ALABAMA
|
Methods to Enable Cholesterol Catabolism in Human Monocyte Derived Macrophages |
JASANOFF, ALAN
|
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
|
Noninvasive Imaging-Based Electrophysiology Using Microelectronic Devices |
KUPPER, THOMAS S CLARK, RACHAEL ANN |
BRIGHAM AND WOMEN'S HOSPITAL
|
Vaccination to Generate Protective Tissue Resident T Cells
|
LECKMAN, JAMES F (contact) WEXLER, BRUCE E.
|
YALE UNIVERSITY
|
Integrated Brain, Body and Social Intervention for ADHD
|
LICHTMAN, JEFF W (contact) MEISTER, MARKUS SANES, JOSHUA R SEUNG, H SEBASTIAN
|
HARVARD UNIVERSITY
|
High Resolution Connectomics of Mammalian Neural Circuits |
LIN, HENING (contact) CERIONE, RICHARD A WEISS, ROBERT S
|
CORNELL UNIVERSITY ITHACA
|
Succinylation and Malonylation as Novel Protein Modifications in Cancer
|
MCDEVITT, TODD C
|
GEORGIA INSTITUTE OF TECHNOLOGY
|
Stem Cell Morphogen Delivery via Engineered Biomaterials |
MOOTHA, VAMSI KRISHNA
|
MASSACHUSETTS GENERAL HOSPITAL
|
Molecular Prostheses for Mitochondrial Disorders
|
NIE, SHUMING (contact) SINGHAL, SUNIL
|
EMORY UNIVERSITY
|
Contrast-Enhanced and Image-Guided Surgery of Lung Cancer
|
NOLTA, JAN A
|
UNIVERSITY OF CALIFORNIA DAVIS
|
Direct Cell to Cell Transfer of microRNA for Tissue Repair |
PAPAVASILIOU, F NINA
|
ROCKEFELLER UNIVERSITY
|
Building Novel Vaccines on a Borrowed Coat
|
PUGLISI, JOSEPH D
|
STANFORD UNIVERSITY
|
Single Molecule Translational Profiling |
ROSS, MARGARET ELIZABETH (contact) MASON, CHRISTOPHER EDWARD
|
WEILL MEDICAL COLLEGE OF CORNELL UNIV
|
Epigenome Interactions in Complex Neurogenetic Disorders
|
2010 NIH Director's Transformative Research Award (R01) - RFA-RM-09-022
2009 NIH Director's Transformative Research Award (R01) - RFA-RM-08-029
This page last reviewed on October 8, 2019