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Funded Research

The Single Cell Analysis Program (SCAP) has transitioned from Common Fund support in 2017. For more information, please visit https://commonfund.nih.gov/singlecell/. Please note that since SCAP is no longer supported by the Common Fund, the program website is being maintained as an archive and will not be updated on a regular basis.

Development of Highly Innovative Tools and Technology for Analysis of Single Cells (SBIR) (R43/R44) PA-13-140
PI NameInstitution NameTitle
BELL, CALEB B (contact)
RUTT, BRIAN KEITH
BELL BIOSYSTEMS, INC.Single Cell Spatiotemporal and Functional Reporting using Magneto-Endosymbionts
DOBES, NICHOLAS CARLCELL MICROSYSTEMS, INC.CellRaft Arrays for Single-cell PCR
HEYMAN, JOHN ASPHEREBIO, INC.Droplet-based Analysis of Secretion and Sorting (DASS) for characterization and selection of individual immune cells
HUANG, CHANGJININFINITESIMAL, LLCHigh-Throughput Microdevice for Temporal Single-Cell Analysis
SCOUTEN, CHARLES WILLIAM (contact)
SCHWEIZER, FELIX
SUN, YING
ROKHAN, LLCCellular Capacitance Monitoring Integration into Digital Patch Clamp Amplifier
YEAKLEY, JOANNE MULLIGANBIOSPYDER TECHNOLOGIES, INC.Multiplexed mRNA and miRNA Profiling of Single Cells

 

Revisions to Add Single Cell Analysis to Active Research Projects (U01) RFA-RM-13-023
PI NameInstitution NameTitle
FRAZER, KELLY A (contact)
CHI, NEIL C
EVANS, SYLVIA M
YEO, EUGENE WEI-MING
ZHANG, KUN
UNIVERSITY OF CALIFORNIA SAN DIEGORegulatory Genomic Studies in a Cohort of IPS Cell Derived Cardiomyocytes

 

Revisions to Add Single Cell Analysis to Active Research Projects (R01) RFA-RM-13-022
PI NameInstitution NameTitle
CHANG, JOHN TUNIVERSITY OF CALIFORNIA SAN DIEGORegulation and Function of Polarity and Asymmetric Cell Division in Immunity
CHEN, C CASEYUNIVERSITY OF SOUTHERN CALIFORNIANovel clone-specific virulence determinants of A. actinomycetemcomitans 
KRAUSE, DIANE SYALE UNIVERSITYMechanisms of megakaryocyte maturation
RAO, DINESH SUNIVERSITY OF CALIFORNIA LOS ANGELESCharacterizing tumor suppressive functions of microRNAs in B-cell neoplasia
ROTHENBERG, ELLEN V. (contact)
CAI, LONG
CALIFORNIA INSTITUTE OF TECHNOLOGYGenomic site binding rules and regulatory factor function in developing T cells
SHIVDASANI, RAMESH ADANA-FARBER CANCER INSTMultidimensional characterization of RNAs and signals in single intestinal cells
TENEN, DANIEL GBETH ISRAEL DEACONESS MEDICAL CENTERMolecular biology of myeloid differentiation
WU, CATHERINE JU-YINGDANA-FARBER CANCER INSTPersonal tumor neoantigens for immunity against chronic lymphocytic leukemia

 

Exceptionally Innovative Tools and Technologies for Single Cell Analysis (R21) RFA-RM-13-021
PI NameInstitution NameTitle
CAI, DAWEN (contact)
YE, BING
UNIVERSITY OF MICHIGANMACS: A genetic labeling tool to depict the complete neuroblast lineage of all neurons in individual Drosophila brains
CHENG, JI-XINPURDUE UNIVERSITY WEST LAFAYETTEMicrosecond Raman spectroscopy: Assessing single cell metabolism in a vital organism
GARTNER, ZEV JORDANUNIVERSITY OF CALIFORNIA, SAN FRANCISCOIdentifying the intercellular networks regulating estrogen receptor expression with a high definition single cell printer
NEMES, PETERGEORGE WASHINGTON UNIVERSITYIn Situ Optoguided Microsampling Single-cell Mass Spectrometry for Elucidating Cell Heterogeneity
PARANT, JOHN MUNIVERSITY OF ALABAMA AT BIRMINGHAMLight-Induced Genetic Alterations within Single Cell of a Live Vertebrate Animal
PERRIMON, NORBERTHARVARD MEDICAL SCHOOLInnovative reporters to characterize heterogeneous states among cells
PRATX, GUILLEMSTANFORD UNIVERSITYReal-time tracking of single cells in live animals
ZARE, RICHARD NSTANFORD UNIVERSITYHigh Spatiotemporal Resolution Mass Spectrometry for Single Cell Analysis 

 

Validation and Advanced Development of Technologies for the Study of Biological Properties of Single Cells (R33) RFA-RM-13-020
PI NameInstitution NameTitle
HOLLEY, SCOTT AYALE UNIVERSITYQuantification and modeling of the emergence of tissue-level mechanics from individual cell heterogeneity
HUANG, BOUNIVERSITY OF CALIFORNIA, SAN FRANCISCOAnalyzing genomic elements in live animals by CRISPR imaging
HUANG, TONY JUNPENNSYLVANIA STATE UNIVERSITY-UNIV PARKValidation of acoustic tweezers for single-cell analyses of purine metabolism
NORRIS, JEREMY LVANDERBILT UNIVERSITYLaser-Based Mass Spectrometry Analysis of Single Cells
RAJ, ARJUNUNIVERSITY OF PENNSYLVANIAValidation and development of single nucleotide variant RNA FISH in single cells in culture and tissue
SOUSA-NEVES, RUI (contact)
MIZUTANI, CLAUDIA
CASE WESTERN RESERVE UNIVERSITYMultidimensional analysis of cell lineages
SUL, JAI-YOONUNIVERSITY OF PENNSYLVANIANuclear pre-mRNA analysis of single cells in brain slice
YOUNG-PEARSE, TRACY LBRIGHAM AND WOMEN'S HOSPITALDetection of cell type specific effects of pathway manipulation in neural cells 

 

Accelerating the Integration and Translation of Technologies to Characterize Biological Processes at the Single Cell Level (R01) RFA-RM-11-015
PI NameInstitution NameTitle
BAO, ZHIRONGSLOAN-KETTERING INSTITUTE FOR CANCER RESAn integrated system to monitor complex tissues at single-cell resolution
BOYDEN, EDWARD S. (contact)
FOREST, CRAIG
ZENG, HONGKUI
MASSACHUSETTS INSTITUTE OF TECHNOLOGYHigh-throughput robotic analysis of integrated neuronal phenotypes
BUSHKIN, YURI (contact)
GENNARO, MARIA LAURA
TYAGI, SANJAY
UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOLRapid Analysis of Single T Cell Immunity Signatures in Tuberculosis
CAI, LONG (contact)
SOMLO, GEORGE
CALIFORNIA INSTITUTE OF TECHNOLOGYMultiplex RNA imaging in single cells by superresolution microscopy& barcode FISH
GERDES, MICHAEL (contact)
COFFEY, ROBERT J.
SHAIKH, KASHAN
GENERAL ELECTRIC GLOBAL RESEARCH CTRValidation of a single cell multiplexed in-situ biomarker analysis platform for p
LOVE, JOHN CHRISTOPHERMASSACHUSETTS INSTITUTE OF TECHNOLOGYNanowell-based single-cell technology for characterizing clinical samples ex vivo
MAYFORD, MARK R.SCRIPPS RESEARCH INSTITUTEActivity Based Tagging of Neurons
VARADARAJAN, NAVIN (contact)
COOPER, LAURENCE J.N.
UNIVERSITY OF HOUSTONQuantitative single-cell biomarkers of T-cells to optimize tumor immunotherapy
WIRTZ, DENISJOHNS HOPKINS UNIVERSITYSingle-cell phenotyping for therapeutic stratification in pancreatic cancer

 

Exceptionally Innovative Tools and Technologies for Single Cell Analysis (R21) RFA-RM-11-014
PI NameInstitution NameTitle
COVERT, MARKUS WSTANFORD UNIVERSITYNew methods for monitoring the immune system, in individual cells and in vivo
DENISENKO, OLEG NUNIVERSITY OF WASHINGTONSingle cell analysis of chromatin changes at individual genes
KARTALOV, EMIL PUNIVERSITY OF SOUTHERN CALIFORNIAHigh-Throughput Single-Cell-PCR Technique for Tissue Analysis of Genetic Heteroge
KIRSCHNER, MARC WALLACEHARVARD UNIVERSITY (MEDICAL SCHOOL)A high-throughput method for simultaneous profiling of mRNA and protein levels in
KONRY, TALI TANIAMASSACHUSETTS GENERAL HOSPITALDevelopment of Microfluidic Nano-Liter Platform for Single Cell Dynamic Monitorin
LEVY, MATTHEW (contact)
SNAPP, ERIK L.
ALBERT EINSTEIN COL OF MED YESHIVA UNIVFluorescent probes for quantitation of secretory protein levels in single cells
LOVE, JOHN CHRISTOPHERMASSACHUSETTS INSTITUTE OF TECHNOLOGYHighly Multiplexed Single-cell Transcript Analysis Using DNA-barcoded Nanowells
MELDRUM, DEIRDRE R.ARIZONA STATE UNIVERSITY-TEMPE CAMPUSIn Situ Single Cell Laser Lysis and Downstream qRT-PCR Profiling
MIZUTANI, CLAUDIA (contact)
GUO, WEIHONG
SOUSA-NEVES, RUI
CASE WESTERN RESERVE UNIVERSITYReal-time visualization of neural stem cell transcriptome
MURRAY, KERMIT KINGLOUISIANA STATE UNIV A&M COL BATON ROUGENanoscale Laser Ablation Capture Mass Spectrometry for Single Cell Proteomics
NAVIN, NICHOLASUNIVERSITY OF TEXAS MD ANDERSON CAN CTRDeveloping a whole-genome sequencing method for single human cells
NEU, COREY PPURDUE UNIVERSITY WEST LAFAYETTECombined Biophysical and Biochemical Study of Single Cells
RESHETNYAK, YANA K. (contact)
ANDREEV, OLEG A
UNIVERSITY OF RHODE ISLANDMapping pH at the surface of individual cell
SIMS, PETER ALANCOLUMBIA UNIVERSITY HEALTH SCIENCESMultiplexed, Single Molecule Protein Identification for Single Cell Proteomics
WANG, YINGXIAOUNIVERSITY OF ILLINOIS URBANA-CHAMPAIGNA Systematic Approach to Engineer Fyn Kinase Biosensor

 

Studies to evaluate cellular heterogeneity using transcriptional profiling of single cells (U01) RFA-RM-11-013
PI NameInstitution NameTitle
EBERWINE, JAMES H (contact)
KIM, JUNHYONG
UNIVERSITY OF PENNSYLVANIARole of Single Cell mRNA Variation in Systems Associated Electrically Excitable C
KNOWLES, JAMES A (contact)
CHOW, ROBERT HSIU-PING
UNIVERSITY OF SOUTHERN CALIFORNIAEvaluation of Cellular Heterogeneity Using Patchclamp and RNA-Seq of Single Cells
ZHANG, KUNUNIVERSITY OF CALIFORNIA SAN DIEGOSingle-cell sequencing and in situ mapping of RNA transcripts in human brains

This page last reviewed on April 12, 2024