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Funded Research

The LINCS program has transitioned from Common Fund support. For more information, please visit the LINCS website.

Please note that since the LINCS program is no longer supported by the Common Fund, the program website is being maintained as an archive and will not be updated on a regular basis.

Library of Integrated Network-Based Cellular Signatures (LINCS): Perturbation-Induced Data and Signature Generation Centers (U54) RFA-RM-13-013
PI NameInstitution NameTitle
GOLUB, TODD R. (contact)
SUBRAMANIAN, ARAVIND
BROAD INSTITUTE, INC.Broad Institute LINCS Center for Transcriptomics
GRAY, JOE W. (contact)
HEISER, LAURA
KORKOLA, JAMES
OREGON HEALTH & SCIENCE UNIVERSITYExtrinsic Perturbations of Cell Physiology and Associated Regulatory Networks
IYENGAR, SRINIVAS RAVI V (contact)
BIRTWISTLE, MARC R
SOBIE, ERIC A
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAIDrug Combination Signatures for Prediction and Mitigation of Toxicity
JAFFE, JACOB DAVIDBROAD INSTITUTE, INC.There and Back Again: Epigenetic Reinforcement of Cellular Signaling States - Overall
SORGER, PETER KARLHARVARD UNIVERSITY (MEDICAL SCHOOL)Pharmaco Response Signatures and Disease Mechanism
THOMPSON, LESLIE MICHELS (contact)
FINKBEINER, STEVEN M
FRAENKEL, ERNEST
ROTHSTEIN, JEFFREY D
SVENDSEN, CLIVE NIELS
UNIVERSITY OF CALIFORNIA-IRVINENeuron and Glial Cellular Signatures from Normal and Diseased iPS Cells

 

Large Scale Production of Perturbagen-Induced Cellular Signatures (U54) RFA-RM-10-003
PI NameInstitution NameTitle
GOLUB, TODD R. (contact) WINCKLER, WENDYBROAD INSTITUTE, INC.Large scale gene expression analysis of cellular states
MITCHISON, TIMOTHY J.(contact) SORGER, PETER KARLHARVARD UNIVERSITY (MEDICAL SCHOOL)Pharmaco Response Signatures and Disease Mechanism

 

Advanced Technologies for Detection of Perturbation-Induced Cellular Signatures (U01) RFA-RM-10-004
PI NameInstitution NameTitle
CALIFANO, ANDREACOLUMBIA UNIVERSITY HEALTH SCIENCESProfiling Signatures of synergistic Chemical Perturbations in Diverse Cellular C
JAFFE, JACOB DAVID (contact) MACCOSS, MICHAEL JBROAD INSTITUTE, INC.Accelerated Protein Signaling Signatures
MELDRUM, DEIRDRE R.ARIZONA STATE UNIVERSITY-TEMPE CAMPUSLive-cell Microarray for high-throughput observation of metabolic signatures
MILLER-JENSEN, KATHRYN (contact) FAN, RONGYALE UNIVERSITYDetection of Protein Signal Transduction Signatures in Single Cells

 

Computational Tool Development and Integrative Data Analysis for LINCS (U01) RFA-RM-10-005
PI NameInstitution NameTitle
CALIFANO, ANDREACOLUMBIA UNIVERSITY HEALTH SCIENCESA Systems Approach to Elucidate Mechanisms of Drug Activity and Sensivity
MEDVEDOVIC, MARIOUNIVERSITY OF CINCINNATIIntegrative statistical methods and tools for analysis of perturbation signatures
SCHURER, STEPHAN CUNIVERSITY OF MIAMI SCHOOL OF MEDICINELINCS Information FramEwork (LIFE) to Integrate and Analyze Diverse Data Set
ZHOU, XIAOBO (contact) CHANG, CHUNG-CHEMETHODIST HOSPITAL RESEARCH INSTITUTEitNETZ: Integrative and Translational Network-based Cellular Signature Analyzer

This page last reviewed on January 31, 2024