Program Snapshot

Image of two cell conditions showing how nuclear DNA can rearrangeUnder different conditions, such as disease, regions of our DNA (different colored ovals) may change shape or location inside the nucleus of a cell (large circles). These movements may start or stop the production of certain proteins at the wrong time.

The goal of the Common Fund’s 4D Nucleome (4DN) program is to study the three-dimensional organization of the nucleus in space and time (the 4th dimension). The nucleus of a cell contains DNA, the genetic “blueprint” that encodes all of the genes a living organism uses to produce proteins needed to carry out life-sustaining cellular functions. Scientists know that how the information in the nucleus organized, stored, and unpackaged are all important to basic human health and we are only starting to learn how changes in this organization can lead to the development of different diseases, such as cancer or our response to infectious agents like viruses.

The 4DN program has generated a variety of tools and resources so scientists can continue to learn about the importance of nuclear organization. Program deliverables currently available through the public 4DN Portal include nearly 2000 datasets from hundreds of experiments, 52 software packages and 23 protocols and reagents for researchers to use.

The first phase of the 4DN program was very successful. but there is still a need to deliver data and tools to the broader biomedical research community to address the role of nuclear organization in health and disease. A second stage of funding for the 4DN program has recently started and will focus on the following initiatives:

Check back regularly for more information on stage 2 of the 4DN program!



This page last reviewed on May 9, 2023